2010 AnnuAl REpoRT - Ciberdem

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Diabetobe Hospital Clínico San Carlos, Madrid www.madrid.org Principal Investigator Manuel Serrano Ríos mserrano.hcsc@salud.madrid.org Associate researchers María Teresa Martínez Larrad, Jesús Álvarez Fernández Represa, Arturo Corbatón, Vicente Estrada, Cristina Fernández Research assistants Covadonga Caso, Bernat Jiménez, Carina Zabena Lab technicians Carmen Obiang, Noelia Rodríguez Administrative staff María del Mar González Total IF: 2.840 Publications: 1, in the second quartile Research grants: 4 International projects: 1 Private funds: 3 Scientific collaborations within CIBERDEM: 4 Clinical practice guidelines: 1 PhD theses: 2 Keywords Epidemiology. Genetics type 2 diabetes. Genomics. Metabolic syndrome. Prevention of type 1 diabetes. Proteomics. Main lines of research -A genowide study of the Spanish population. Search of loci for FG, FI, HbA1C and others. -A genomic, lipidomic and proteomic study of subcutaneous/ abdominal adipose tissue and its relationship to type 2 diabetes and obesity. -Genes and inflammatory markers in children with obesity and/or metabolic syndrome. -Analysis of genetic markers, circulating adipokines and insulin-resistance status in HIV naïve patients and those undergoing retroviral treatment. -Analysis of genetic markers, circulating adipokines and insulin-resistance status in polycystic ovary syndrome and obesity. -Nutritional primary prevention of type 1 diabetes in children (TRIGR). Publications* Original article WWOX gene is associated with HDL cholesterol and triglyceride levels Sáez ME, González-Pérez A, Martínez-Larrad MT, Gayán J, Real LM, Serrano-Ríos M, Ruiz A *Only those published in 2010, with CIBERDEM listed among the affiliations, which are related to CIBERDEM’s field of research and are located in the first or second quartile of their subject category are included. 2010 Annual Report 73
BMC Med Genet, 11, 148 (2010) IF: 2.840 second quartile Books Obesity, Elsevier (2010) Authors: Manuel Serrano Ríos, José M Ordovás, José A Gutiérrez Fuentes Type 2 Diabetes Mellitus, Elsevier (2010) Authors: Manuel Serrano Ríos, José A Gutiérrez Fuentes Book chapters Book: Obesity, Elsevier (2010) Chapter: Obesity and Type 2 Diabetes Mellitus. The reciprocal impact Authors: Manuel Serrano Ríos, José A Gutiérrez Fuentes Pages: 215-232 Book: Type 2 Diabetes Mellitus, Elsevier (2010) Chapter: Classification of Dibetes Mellitus: Criteria for Diagnosis Authors: Manuel Serrano Ríos, Jesús Reviriego, José A Gutiérrez Fuentes Pages: 1-23 Research grants International project Nutritional Primary Prevention of Type1 Diabetes in Children NIH, QLK1-CT-2002-00372: 2002-2012 Principal Investigator: Manuel Serrano Ríos Private funds Morbi-Mortabilidad y Caracterización Genética en el ámbito Rural y Urbano de la Provincia de Segovia Fundación Mutua Madrileña, FMM08: 2008-2010 Principal Investigators: Cristina Fernández Pérez, Manuel Serrano Ríos An analysis of the change in the distribution of body fat and the relationship with adipokine levels in patients with HIV undergoing retroviral treatment Fipse, 236697/07/07: 2007-2010 Principal Investigators: Vicente Estrada, Manuel Serrano Ríos Metabolic syndrome, genes, inflammation markers Lilly SA: 2006-2011 Principal Investigator: Manuel Serrano Ríos Fat tissue in morbid obesity: from histology to gene expression, proteomics and lipidomics. 74 CibeRdem
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2010 Annual Report CIBERDEM Centro
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Letter from the Scientific Director
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Contents Prologue Research results
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Research results Publications In 20
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Project management Introduction The
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Training programme Introduction The
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Outreach activities CIBERDEM Fundra
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More about CIBERDEM The Centro de I
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Human Resources In 2010, CIBERDEM h
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Transversal projects Di@bet.es Stud
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Di@bet.es Study Introduction Attemp
Page 24 and 25: CIBERDEM Projects Introduction CIBE
Page 26 and 27: girls (girls born small for gestati
Page 28 and 29: Biobank Introduction and objectives
Page 30 and 31: Metabolomics Platform Introduction
Page 33 and 34: Area 1 Insulin signalling and resis
Page 35 and 36: Diabetes and cardiovascular Faculta
Page 37 and 38: Metabolomics Platform Universitat R
Page 39 and 40: Obesity, inflammation and insulin r
Page 41 and 42: Mechanisms of control of glucose an
Page 43 and 44: Metabolic engineering and diabetes
Page 45 and 46: Molecular mechanisms of insulin res
Page 47 and 48: Molecular characteristics, and acti
Page 49 and 50: Heterogenic and polygenic diseases.
Page 51: Principal Investigator: Antonio Zor
Page 54 and 55: The research activity of this area
Page 56 and 57: The cationic cluster of group IVA p
Page 58 and 59: agent that affects the enterohepati
Page 60 and 61: Dyslipidaemia, inflammation and end
Page 62 and 63: Daño orgánico en la diabetes mell
Page 64 and 65: Proteomic analysis of plasma in the
Page 66 and 67: Prenatal growth restriction and sub
Page 68 and 69: The effects of metformin on cardiov
Page 70 and 71: Lipids and Arteriosclerosis Researc
Page 72 and 73: Review Pitavastatin - from clinical
Page 76 and 77: Scientific collaborations within CI
Page 78 and 79: Atherosclerosis, 209, 201-205 (2010
Page 80 and 81: Solvay, SA: 2008-2010 Principal Inv
Page 82 and 83: Endocrinology and Nutrition Service
Page 84 and 85: Prevención de la Diabetes mellitus
Page 86 and 87: Pharmacological targets in inflamma
Page 88 and 89: Diabetes and Metabolic Associated D
Page 90 and 91: Autonomous Community project Grup d
Page 92 and 93: Area 3 of CIBERDEM comprises thirte
Page 94 and 95: Escrivá F, Alvarez C J Mol Endocri
Page 96 and 97: Am J Physiol Endocrinol Metab, 298,
Page 98 and 99: Transgenic animal models and gene t
Page 100 and 101: Ayuso E, Mingozzi F, Bosch F Curr G
Page 102 and 103: Laboratory of Molecular Endocrinolo
Page 104 and 105: Hospital de Cruces Diabetes Researc
Page 106 and 107: Research grants International proje
Page 108 and 109: Proinsulin and tyrosine hydroxilase
Page 110 and 111: Genomic programming of beta cells I
Page 112 and 113: Diabetes and obesity: biopathology
Page 114 and 115: Utilidad de la ecografía arterial
Page 116 and 117: Islet cell and stem cell physiology
Page 118 and 119: in diabetic patients with chronic c
Page 120 and 121: Liraglutide versus sitagliptin for
Page 122 and 123: Unit of Cell Physiology and Nutriti
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National projects Efectos a corto y
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Altirriba J, Gasa R, Casas S, Ramí
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Transcriptional mechanisms of pancr
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Epilogue
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Keyword index* Beta-cell signal tra
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Association of selected ABC gene fa
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Leiter LA, Levitt NS, Mareev V, Mar
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Low body adiposity and high leptine
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Alvaro A, Rosales R, Masana L, Vall
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The apolipoprotein A5 (APOA5) gene
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2010 AnnuAl REpoRT - Ciberdem

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