2010 AnnuAl REpoRT - Ciberdem

Brain glucose sensor, satiety control, insulin
resistance and type 2 diabetes
Universidad Complutense de Madrid
www.ucm.es
Principal Investigator Enrique Blázquez eblazquez@med.ucm.es Associate researchers Elvira Álvarez García, María Ángeles Navas
Hernández, Isabel Roncero Rincón, Juan Miguel Ruiz Albusac, María del Carmen Sanz Miguel, Esther Velázquez Sánchez PhD students
Carmen García Herrero, Verónica Hurtado Carneiro Lab manager Pedro Alberto Barrio Lab technicians Alberto Crespo, Laura del Barrio
Diez, Ana María de Lucas Cerrillo
Total IF: 4.395
Publications: 1, in the first quartile
With other CIBERDEM groups: 1
Research grants: 5
National projects: 1
Autonomous Community projects: 2
Private funds: 2
Scientific collaborations within CIBERDEM: 2
Keywords
Genetics type 2 diabetes. Hormone receptors. Incretins.
Stem cells. Weight regulation and obesity.
Main lines of research
-Modifications of cerebral glucose metabolism in
pathophysiological states related to feeding behaviour.
-The effects of GLP-1 and GLP-2 on the expression and activity
of hypothalamic metabolic sensors and characterization of
the neuroprotective role of these peptides.
-The effect of GLP-2 on the proliferation of cultured rat
astrocytes.
-Signalling and the biological effects of GLP-1 on
mesenchymal stem cells of human bone marrow and mouse
embryonic stem cells - its effect on cell differentiation.
-Molecular diagnosis of monogenic diabetes (MODY) and
the functional characterization of MODY mutations.
Publications*
Original article
Signaling and biological effects of glucagon-like peptide
1 on the differentiation of mesenchymal stem cells from
human bone marrow
Sanz C, Vázquez P, Blázquez C, Barrio PA, Alvarez M del
M, Blázquez E
*Only those published in 2010, with CIBERDEM listed among the affiliations, which are related to CIBERDEM’s field of research and are
located in the first or second quartile of their subject category are included.
94 CibeRdem