Endocrinology and Nutrition Service Hospital Regional Universitario Carlos Haya, Málaga www.carloshaya.net www.imabis.org Principal Investigator Federico Soriguer federico.soriguer.sspa@juntadeandalucia.es Associate researchers María Cruz Almaraz, Isabel Esteva de Antonio, Juan Miguel Gómez, María Stella González, Sonsoles Morcillo, Gabriel Olveira, Gemma Rojo, María Soledad Ruiz de Adana, Sergio Valdés Postdoctoral fellow Eva García Research assistants Isabel Cardona, Sara García, Francisca Linares, Gracia María Martín, Nuria Porras Nursing assistant M José Moreno PhD students Carolina Gutiérrez, Juan José Haro, Elehazara Rubio, Gracia María Martín Lab technician María de Haro Martín Administrative staff Patricia González Total IF: 24.111 Publications: 6, 1 of them in the first decile, 4 in the first quartile and 1 in the second quartile With other CIBERDEM groups: 2 With other CIBERs: 5 With other international groups: 1 Research grants: 17 European projects: 1 National projects: 8 Autonomous Community projects: 8 Scientific collaborations within CIBERDEM: 3 Clinical trials: 5 PhD theses: 1 Keywords Epidemiology. Insulin therapy. Metabolic syndrome. Prediction/prevention of type 2 diabetes. Weight regulation and obesity. Main lines of research -The biomolecular epidemiology of diabetes, obesity and metabolic syndrome (Pizarra Study, Egabro Study, Di@bet. es Study, Di@bet.an Study). -The study of insulin resistance in patients with extreme obesity undergoing bariatric surgery. -Fatty acids, insulin resistance and adipocyte metabolism. -New technologies applied to the treatment of type 1 diabetes. Publications* Original articles Intake and home use of olive oil or mixed oils in relation to healthy lifestyles in a Mediterranean population. Findings *Only those published in <strong>2010</strong>, with CIBERDEM listed among the affiliations, which are related to CIBERDEM’s field of research and are located in the first or second quartile of their subject category are included. <strong>2010</strong> Annual Report 81
from the prospective Pizarra study Soriguer F, Almaraz MC, García-Almeida JM, Cardona I, Linares F, Morcillo S, García-Escobar E, Dobarganes MC, Olveira G, Hernando V, Valdes S, Ruiz-de-Adana MS, Esteva I, Rojo-Martínez G Br J Nutr, 103, 114-122 (<strong>2010</strong>) IF: 3.446 first quartile. With other CIBERs: CIBEROBN Jejunal wall triglyceride concentration of morbidly obese persons is lower in those with type 2 diabetes mellitus Soriguer F, García-Serrano S, Garrido-Sánchez L, Gutierrez- Repiso C, Rojo-Martínez G, Garcia-Escobar E, García- Arnés J, Gallego-Perales JL, Delgado V, García-Fuentes E J Lipid Res, 51, 3516-3523 (<strong>2010</strong>) IF: 4.917 first quartile. With other CIBERs: CIBEROBN Nutritional regulation of interleukin-6 release from adipocytes García-Escobar E, Rodríguez-Pacheco F, García-Serrano S, Gómez-Zumaquero JM, Haro-Mora JJ, Soriguer F, Rojo- Martínez G Int J Obes, 34, 1328-1332 (<strong>2010</strong>) IF: 4.343 first quartile. With other CIBERs: CIBEROBN Olive oil and health: summary of the II international conference on olive oil and health consensus report, Jaén and Córdoba (Spain) 2008 López-Miranda J, Pérez-Jiménez F, Ros E, De Caterina R, Badimón L, Covas MI, Escrich E, Ordovás JM, Soriguer F, Abiá R, de la Lastra CA, Battino M, Corella D, Chamorro- Quirós J, Delgado-Lista J, Giugliano D, Esposito K, Estruch R, Fernandez-Real JM, Gaforio JJ, La Vecchia C, Lairon D, López-Segura F, Mata P, Menéndez JA, Muriana FJ, Osada J, Panagiotakos DB, Paniagua JA, Pérez-Martinez P, Perona J, Peinado MA, Pineda-Priego M, Poulsen HE, Quiles JL, Ramírez-Tortosa MC, Ruano J, Serra-Majem L, Solá R, Solanas M, Solfrizzi V, de la Torre-Fornell R, Trichopoulou A, Uceda M, Villalba-Montoro JM, Villar-Ortiz JR, Visioli F, Yiannakouris N Nutr Metab Cardiovasc Dis, 20, 284-294 (<strong>2010</strong>) IF: 3.517 first quartile. With other international groups. With other CIBERDEM groups: L Masana. With other CIBERs: CIBEROBN PPARgamma expression after a high-fat meal is associated with plasma superoxide dismutase activity in morbidly obese persons Garcia-Fuentes E, Murri M, Garrido-Sanchez L, Garcia- Serrano S, García-Almeida JM, Moreno-Santos I, Tinahones FJ, Macias-Gonzalez M Obesity (Silver Spring), 18, 952-958 (<strong>2010</strong>) IF: 3.366 second quartile. With other CIBERs: CIBEROBN Soluble fibre (Plantago ovata husk) reduces plasma low-density lipoprotein (LDL) cholesterol, triglycerides, insulin, oxidised LDL and systolic blood pressure in hypercholesterolaemic patients: A randomised trial Solà R, Bruckert E, Valls RM, Narejos S, Luque X, Castro-Cabezas M, Doménech G, Torres F, Heras M, Farrés X, Vaquer JV, Martínez JM, Almaraz MC, Anguera A Atherosclerosis, 211, 630-637 (<strong>2010</strong>) IF: 4.522 first decile. With other CIBERDEM groups: L Masana Research grants European project REPROBESITY: Search For New Therapeutic Agents Against Complicated Obesity By Reprofiling Existing Drugs European Union, Seventh Framework Programme, FP7- HEALTH-2007-B: 2009-2012 Principal Investigator: Fernando Rodríguez de Fonseca National projects Estudio de los polimorfismos de los genes Ar, Er beta y Cyp19, y de reordenaciones en los cromosomas X e Y, en dos poblaciones de personas con trastorno de identidad de género (TIG) Ministerio de Ciencia e Innovación, Proyectos de Investigación Fundamental no orientada: <strong>2010</strong>-12 Principal Investigator: Eduardo Pásaro Associate investigators: Rosa Fernández, Blanca Laffon, Antonio Guillamón, Isabel Esteva, Maricruz Almaraz, Raquel Yahyahoui, Juan Haro, Esther Gómez Gil Epigenética y Riesgo de diabetes mellitus tipo 2 Instituto de Salud Carlos III, PS09/0217: <strong>2010</strong>-2012 Principal Investigator: Sonsoles Morcillo Espina Associate investigators: Juan Miguel Gómez Zumaquero, Elehazara Rubio Martín, Gracia María Martín Núñez, Gabriel Olveira, M Soledad Ruiz de Adana, Isabel Esteva de Antonio Estudio del papel biológico de la SCD1 como posible mediador entre la obesidad e insulinresistencia en individuos obesos mórbidos desde una aproximación in vivo e in vitro Instituto de Salud Carlos III, PS09/01060: <strong>2010</strong>-2012 Principal Investigator: Eduardo García Fuentes Associate investigators: Sara García Serrano, Carolina Gutiérrez Repiso, Gabriel Olveira, Eva García Escobar, José Luis Gallego Perales, Juan García Arnés Adaptación psicosocial, calidad de vida, y demanda de asistencia sanitaria durante 10 años en personas diagnosticadas de trastorno de la identidad de género Ministerio de Igualdad, IMG 2009-PI040964: 2009-2011 Principal Investigator: Esther Gómez Gil Associate investigators: I Esteva, MC Almaraz, J Martínez, A Guillamón, M Salamero, T Godás 82 CibeRdem
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2010 Annual Report CIBERDEM Centro
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Letter from the Scientific Director
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Contents Prologue Research results
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Research results Publications In 20
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Project management Introduction The
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Training programme Introduction The
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Outreach activities CIBERDEM Fundra
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More about CIBERDEM The Centro de I
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Human Resources In 2010, CIBERDEM h
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Transversal projects Di@bet.es Stud
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Di@bet.es Study Introduction Attemp
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CIBERDEM Projects Introduction CIBE
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girls (girls born small for gestati
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Biobank Introduction and objectives
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Metabolomics Platform Introduction
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- Page 39 and 40: Obesity, inflammation and insulin r
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- Page 45 and 46: Molecular mechanisms of insulin res
- Page 47 and 48: Molecular characteristics, and acti
- Page 49 and 50: Heterogenic and polygenic diseases.
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- Page 72 and 73: Review Pitavastatin - from clinical
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- Page 94 and 95: Escrivá F, Alvarez C J Mol Endocri
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Keyword index* Beta-cell signal tra
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Association of selected ABC gene fa
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Leiter LA, Levitt NS, Mareev V, Mar
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Low body adiposity and high leptine
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Alvaro A, Rosales R, Masana L, Vall
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The apolipoprotein A5 (APOA5) gene
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www.ciberdem.org/annualreport CIBER