2010 AnnuAl REpoRT - Ciberdem
2010 AnnuAl REpoRT - Ciberdem
2010 AnnuAl REpoRT - Ciberdem
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Molecular mechanisms of insulin resistance and<br />
sensitivity in peripheral tissues<br />
Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas, Madrid<br />
www.iib.uam.es<br />
Principal Investigator Ángela Martínez Valverde avalverde@iib.uam.es Postdoctoral fellows Águeda González, Jesús Revuelta, Beatriz<br />
Santamaría PhD students Virginia Pardo, Maysa Mobasher Lab technician Soledad Miranda<br />
Total IF: 21.536<br />
Publications: 4, 1 of them in the first decile, 2 in the first quartile<br />
and 1 in the second quartile<br />
With other CIBERDEM groups: 2<br />
With other international groups: 2<br />
Research grants: 3<br />
National projects: 2<br />
Private funds: 1<br />
Scientific collaborations within CIBERDEM: 1<br />
Keywords<br />
Cytokines. Hormone receptors. Insulin action. Insulin sensitivity<br />
and resistance. Retinopathy. Weight regulation and obesity.<br />
Main lines of research<br />
-The inhibition of PTP1B by genetic and pharmacological<br />
approaches in systemic IRS-2-deficient mice as a molecular<br />
strategy to restore IRS-1-mediated insulin signalling and<br />
hepatic insulin sensitization.<br />
-The study of the critical nodes of the insulin-signalling<br />
cascade in human biopsies from patients with non-alcoholic<br />
hepatic steatosis (NAFLD), steatohepatitis (NASH) and<br />
hepatitis virus C infection (HCV).<br />
-The effects of insulin sensitization by PTP1B deficiency on<br />
hepatic regeneration in mice fed on chow or a high fat diet:<br />
molecular mechanisms involved.<br />
-The effects of PTP1B deficiency on age-induced insulin<br />
resistance and metabolic damage.<br />
-The effect of PTP1B deficiency on postnatal liver growth:<br />
alterations in the GH/IGF-1 system.<br />
-The possible beneficial effect of PTP1B inhibition in the<br />
impairment of survival of photoreceptor cells in IRS-2-<br />
deficient mice.<br />
-Stress and survival signalling pathways in diabetic retinopathy.<br />
Publications*<br />
Original articles<br />
Beneficial effects of PTP1B deficiency on brown adipocyte<br />
*Only those published in <strong>2010</strong>, with CIBERDEM listed among the affiliations, which are related to CIBERDEM’s field of research and are<br />
located in the first or second quartile of their subject category are included.<br />
44 CibeRdem
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