2010 AnnuAl REpoRT - Ciberdem

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Hospital de Cruces Diabetes Research Group Hospital de Cruces, Barakaldo www.hospitalcruces.com Principal Investigator Luis Castaño lcastano@osakidetza.net Associate researchers María Ángeles Aniel Quiroga, Jose Ramon Bilbao, María Ángeles Busturia, Alicia Cortázar, Sonia Gaztambide, Itxaso Rica, Federico Vázquez, Amaia Vela Postdoctoral fellows Rosa María Martínez, Miriam Ramírez Research assistant Inés María Urrutia PhD students Anibal Aguayo, Oihana Belar, Ainara Castellanos, Javier de las Heras, Teba González, Tamara López, Leticia Plaza, Nora Fernández Lab managers Galder Gutiérrez, Gustavo Pérez de Nanclares Nurse Alicia Cobo Nutritionist Ana María Megido Administrative staff Sorkunde Rivero Total IF: 116.098 Publications: 6, 4 of them in the first decile and 2 in the second quartile With other CIBERDEM groups: 1 With other CIBERs: 2 With other international groups: 5 Research grants: 6 International projects: 2 National projects: 1 Autonomous Community projects: 3 Scientific collaborations within CIBERDEM: 3 Clinical trials: 6 PhD theses: 1 Awards: 2 Keywords Clinical diabetes. Genetics type 1 diabetes. Monogenic diabetes. Oral pharmacological agents. Prediction/ prevention of type 1 diabetes. Main lines of research -The identification of additional genetic susceptibility markers for type 1 diabetes and related autoimmune disorders in the extended MHC (6p21) and other regions using high throughput genotyping. -The study of immune mediators of disease development, characterization of novel autoantigens/ antibodies and cell populations in patients: Th1, Th2 and Th17 responses. -The identification of new genes responsible for monogenic diabetes by genome wide analysis (both CGI and CGH approaches). -The molecular and clinical characterization of monogenic 2010 Annual Report 103
diabetes and new therapeutic strategies for KATP channel alterations. -The prediction and prevention of type 1 diabetes. -The control of diabetes complications. -The epidemiology of diabetes. Publications* Original articles Effect of nateglinide on the incidence of diabetes and cardiovascular events NAVIGATOR Study Group, Holman RR, Haffner SM, McMurray JJ, Bethel MA, Holzhauer B, Hua TA, Belenkov Y, Boolell M, Buse JB, Buckley BM, Chacra AR, Chiang FT, Charbonnel B, Chow CC, Davies MJ, Deedwania P, Diem P, Einhorn D, Fonseca V, Fulcher GR, Gaciong Z, Gaztambide S, Giles T, Horton E, Ilkova H, Jenssen T, Kahn SE, Krum H, Laakso M, Leiter LA, Levitt NS, Mareev V, Martinez F, Masson C, Mazzone T, Meaney E, Nesto R, Pan C, Prager R, Raptis SA, Rutten GE, Sandstroem H, Schaper F, Scheen A, Schmitz O, Sinay I, Soska V, Stender S, Tamás G, Tognoni G, Tuomilehto J, Villamil AS, Vozár J, Califf RM N Engl J Med, 362, 1463-1476 (2010) IF: 47.050 first decile. With other international groups Effect of valsartan on the incidence of diabetes and cardiovascular events NAVIGATOR Study Group, McMurray JJ, Holman RR, Haffner SM, Bethel MA, Holzhauer B, Hua TA, Belenkov Y, Boolell M, Buse JB, Buckley BM, Chacra AR, Chiang FT, Charbonnel B, Chow CC, Davies MJ, Deedwania P, Diem P, Einhorn D, Fonseca V, Fulcher GR, Gaciong Z, Gaztambide S, Giles T, Horton E, Ilkova H, Jenssen T, Kahn SE, Krum H, Laakso M, Leiter LA, Levitt NS, Mareev V, Martinez F, Masson C, Mazzone T, Meaney E, Nesto R, Pan C, Prager R, Raptis SA, Rutten GE, Sandstroem H, Schaper F, Scheen A, Schmitz O, Sinay I, Soska V, Stender S, Tamás G, Tognoni G, Tuomilehto J, Villamil AS, Vozár J, Califf RM N Engl J Med, 362, 1477-1490 (2010) IF: 47.050 first decile. With other international groups Recessive mutations in the INS gene result in neonatal diabetes through reduced insulin biosynthesis Garin I, Edghill EL, Akerman I, Rubio-Cabezas O, Rica I, Locke JM, Maestro MA, Alshaikh A, Bundak R, del Castillo G, Deeb A, Deiss D, Fernandez JM, Godbole K, Hussain K, O’Connell M, Klupa T, Kolouskova S, Mohsin F, Perlman K, Sumnik Z, Rial JM, Ugarte E, Vasanthi T; Neonatal Diabetes International Group, Johnstone K, Flanagan SE, Martínez R, Castaño C, Patch AM, Fernández-Rebollo E, Raile K, Morgan N, Harries LW, Castaño L, Ellard S, Ferrer J, Perez de Nanclares G, Hattersley AT Proc Natl Acad Sci U S A, 107, 3105-3110 (2010) IF: 9.432 first decile. With other international groups. With other CIBERDEM groups: J Ferrer. With other CIBERs: CIBERER The first clinical case of a mutation at residue K185 of Kir6.2 (KCNJ11): a major ATP-binding residue Shimomura K, de Nanclares GP, Foutinou C, Caimari M, Castaño L, Ashcroft FM Diabet Med, 27, 225-229 (2010) IF: 3.182 second quartile. With other international groups Book chapters Book: Diagnóstico y tratamiento de las Enfermedades Metabólicas Hereditarias, Ed. Ergón (2010) Chapter: Hiperinsulinismo persistente en el neonato Authors: Castaño L, Pérez de Nanclares G, Vela A, Garin I Pages: 364-375 Book: Tecnologías aplicadas a la diabetes, Sociedad Española de Diabetes (2010) Chapter: Retinografía con cámara de retina no midriática para el cribado de la retinopatía diabética Authors: Vázquez San Miguel F, Goñi Iriarte MJ, Martínez Alday N Pages: 103-124 Heterozygous glucokinase mutations and birth weight in Spanish children de Las Heras J, Martínez R, Rica I, de Nanclares GP, Vela A, Castaño L; Spanish MODY Group Diabet Med, 27, 608-610 (2010) IF: 3.182 second quartile Neonatal diabetes caused by mutations in sulfonylurea receptor 1: interplay between expression and Mg-nucleotide gating defects of ATP-sensitive potassium channels Zhou Q, Garin I, Castaño L, Argente J, Muñoz-Calvo MT, Perez de Nanclares G, Shyng SL J Clin Endocrinol Metab, 95, E473-478 (2010) IF: 6.202 first decile. With other international groups. With other CIBERs: CIBEROBN Functional characterization of SUR1 mutations: 86 Rb + efflux profile from COS cells transiently expressing WT or mutant K ATP channel subunits. *Only those published in 2010, with CIBERDEM listed among the affiliations, which are related to CIBERDEM’s field of research and are located in the first or second quartile of their subject category are included. 104 CibeRdem
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2010 Annual Report CIBERDEM Centro
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Letter from the Scientific Director
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Contents Prologue Research results
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Research results Publications In 20
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Project management Introduction The
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Training programme Introduction The
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Outreach activities CIBERDEM Fundra
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More about CIBERDEM The Centro de I
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Human Resources In 2010, CIBERDEM h
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Transversal projects Di@bet.es Stud
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Di@bet.es Study Introduction Attemp
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CIBERDEM Projects Introduction CIBE
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girls (girls born small for gestati
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Biobank Introduction and objectives
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Metabolomics Platform Introduction
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Area 1 Insulin signalling and resis
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Diabetes and cardiovascular Faculta
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Metabolomics Platform Universitat R
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Obesity, inflammation and insulin r
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Mechanisms of control of glucose an
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Metabolic engineering and diabetes
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Molecular mechanisms of insulin res
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Molecular characteristics, and acti
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Heterogenic and polygenic diseases.
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Principal Investigator: Antonio Zor
Page 54 and 55: The research activity of this area
Page 56 and 57: The cationic cluster of group IVA p
Page 58 and 59: agent that affects the enterohepati
Page 60 and 61: Dyslipidaemia, inflammation and end
Page 62 and 63: Daño orgánico en la diabetes mell
Page 64 and 65: Proteomic analysis of plasma in the
Page 66 and 67: Prenatal growth restriction and sub
Page 68 and 69: The effects of metformin on cardiov
Page 70 and 71: Lipids and Arteriosclerosis Researc
Page 72 and 73: Review Pitavastatin - from clinical
Page 74 and 75: Diabetobe Hospital Clínico San Car
Page 76 and 77: Scientific collaborations within CI
Page 78 and 79: Atherosclerosis, 209, 201-205 (2010
Page 80 and 81: Solvay, SA: 2008-2010 Principal Inv
Page 82 and 83: Endocrinology and Nutrition Service
Page 84 and 85: Prevención de la Diabetes mellitus
Page 86 and 87: Pharmacological targets in inflamma
Page 88 and 89: Diabetes and Metabolic Associated D
Page 90 and 91: Autonomous Community project Grup d
Page 92 and 93: Area 3 of CIBERDEM comprises thirte
Page 94 and 95: Escrivá F, Alvarez C J Mol Endocri
Page 96 and 97: Am J Physiol Endocrinol Metab, 298,
Page 98 and 99: Transgenic animal models and gene t
Page 100 and 101: Ayuso E, Mingozzi F, Bosch F Curr G
Page 102 and 103: Laboratory of Molecular Endocrinolo
Page 106 and 107: Research grants International proje
Page 108 and 109: Proinsulin and tyrosine hydroxilase
Page 110 and 111: Genomic programming of beta cells I
Page 112 and 113: Diabetes and obesity: biopathology
Page 114 and 115: Utilidad de la ecografía arterial
Page 116 and 117: Islet cell and stem cell physiology
Page 118 and 119: in diabetic patients with chronic c
Page 120 and 121: Liraglutide versus sitagliptin for
Page 122 and 123: Unit of Cell Physiology and Nutriti
Page 124 and 125: National projects Efectos a corto y
Page 126 and 127: Altirriba J, Gasa R, Casas S, Ramí
Page 128 and 129: Transcriptional mechanisms of pancr
Page 131 and 132: Epilogue
Page 133 and 134: Keyword index* Beta-cell signal tra
Page 135 and 136: Association of selected ABC gene fa
Page 137 and 138: Leiter LA, Levitt NS, Mareev V, Mar
Page 139 and 140: Low body adiposity and high leptine
Page 141 and 142: Alvaro A, Rosales R, Masana L, Vall
Page 143 and 144: The apolipoprotein A5 (APOA5) gene
Page 145 and 146: www.ciberdem.org/annualreport CIBER
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2010 AnnuAl REpoRT - Ciberdem

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