Autonomous Community project Grup de recerca en diabetis i co-morbiditats associades. DiReCor Generalitat de Catalunya, AGAUR, 2009 SGR 01257: 2009- 2013 Principal Investigator: Joan Vendrell Ortega Associate investigators: Miriam Campos, Victoria Ceperuelo, Xavier Escoté, Luís Gallart, Cristina Gutiérrez, Elsa Maymó, Ana Megía, Mercedes Miranda, Matilde Rodríguez, Inmaculada Simón Private funds El papel de la citoquina TWEAK en la diabetes gestacional y su relación con otras adipoquinas y la sensibilidad a la insulina Novo Nordisk: 2009-2011 Principal Investigator: Joan Vendrell Ortega Associate investigators: Xavier Escoté, Ana Megía, Inmaculada Simón PhD theses Estudio del canal de glicerol AQP7 y de la adipoquina ZAG en el ámbito de la obesidad, la diabetes tipo 2 y el síndrome metabólico. Dos proteínas implicadas en la lipólisis del tejido adiposo Author: Victoria Ceperuelo Mallafré Thesis advisor: Joan Vendrell Ortega University: Universitat Rovira i Virgili Thesis defense date: May 14, <strong>2010</strong> Awards Award for a short term fellowship to visit the Montpellier Cancer Research Institute, Montpellier, EMBO-European Molecular Biology Organization (<strong>2010</strong>) Awardee: Xavier Escoté ■ Biology of GLP1 in adipose tissue: Characterization of a new insulin-mediated adipose cell proliferation control factor and its implications in inflammation and diabetes Laboratorios MSD: 2008-<strong>2010</strong> Principal Investigator: Joan Vendrell Ortega Scientific collaborations within CIBERDEM Adult adipose tissue-derived progenitor cells: the influence of the clinical phenotype and adipose depot origin on their biological properties STEMOB: 2009-<strong>2010</strong> Coordinator: Joan J Vendrell CIBERDEM groups: J Vendrell, S Fernández Veledo, A Zorzano, J Balsinde, AM Gómez Foix, E Montanya, R Simó, M Vázquez Carrera Determinants of insulin resistance and glucose tolerance disorders, including diabetes, in severe obesity and their changes after bariatric surgery-induced weight loss DIASOBS: 2009-<strong>2010</strong> Coordinator: Héctor F Escobar Morreale CIBERDEM groups: J Vendrell, X Correig, E Montanya, HF Escobar Morreale, R Simó Di@bet.es Study: 1st epidemiological study of the prevalence of type 2 diabetes in Spain Coordinator: F Soriguer CIBERDEM groups: J Vendrell, F Soriguer, R Carmena, L Castaño, R Gomis, M Serrano Ríos CIBERDEM Biobank Coordinator: A Novials CIBERDEM Biobank Nodes: J Vendrell, R Gomis, A Novials, L Masana, L Castaño, M Serrano Ríos, F Soriguer, R Carmena, M Blanco Vaca Immunostaining in Caco-2 polarized cells. Differentiated Caco-2 cells were immunostained with several organelle markers: A, Golgi (GM130); B, ER (calreticulin); C, F-actin (phalloidin) and D, tight junctions (ZO-1). <strong>2010</strong> Annual Report 89
Area 3 Islet dysfunction, destruction and regeneration Autoimmunity Impact on the pathogenesis of diabetes Total IF: 369.25 Publications: 45 20 of them in the first decile 16 in the first quartile and 9 in the second quartile With other CIBERDEM groups: 12 With other CIBERs: 5 Research grants (through associate institutions): 68 Scientific collaborations within CIBERDEM: 27 Clinical trials: 21 Patents: 4 PhD theses: 8
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2010 Annual Report CIBERDEM Centro
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Letter from the Scientific Director
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Contents Prologue Research results
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Research results Publications In 20
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Project management Introduction The
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Training programme Introduction The
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Outreach activities CIBERDEM Fundra
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More about CIBERDEM The Centro de I
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Human Resources In 2010, CIBERDEM h
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Transversal projects Di@bet.es Stud
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Di@bet.es Study Introduction Attemp
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CIBERDEM Projects Introduction CIBE
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girls (girls born small for gestati
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Biobank Introduction and objectives
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Metabolomics Platform Introduction
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Area 1 Insulin signalling and resis
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Diabetes and cardiovascular Faculta
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Metabolomics Platform Universitat R
- Page 39 and 40: Obesity, inflammation and insulin r
- Page 41 and 42: Mechanisms of control of glucose an
- Page 43 and 44: Metabolic engineering and diabetes
- Page 45 and 46: Molecular mechanisms of insulin res
- Page 47 and 48: Molecular characteristics, and acti
- Page 49 and 50: Heterogenic and polygenic diseases.
- Page 51: Principal Investigator: Antonio Zor
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- Page 58 and 59: agent that affects the enterohepati
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- Page 64 and 65: Proteomic analysis of plasma in the
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- Page 68 and 69: The effects of metformin on cardiov
- Page 70 and 71: Lipids and Arteriosclerosis Researc
- Page 72 and 73: Review Pitavastatin - from clinical
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- Page 78 and 79: Atherosclerosis, 209, 201-205 (2010
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- Page 108 and 109: Proinsulin and tyrosine hydroxilase
- Page 110 and 111: Genomic programming of beta cells I
- Page 112 and 113: Diabetes and obesity: biopathology
- Page 114 and 115: Utilidad de la ecografía arterial
- Page 116 and 117: Islet cell and stem cell physiology
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- Page 122 and 123: Unit of Cell Physiology and Nutriti
- Page 124 and 125: National projects Efectos a corto y
- Page 126 and 127: Altirriba J, Gasa R, Casas S, Ramí
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- Page 131 and 132: Epilogue
- Page 133 and 134: Keyword index* Beta-cell signal tra
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Alvaro A, Rosales R, Masana L, Vall
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The apolipoprotein A5 (APOA5) gene
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www.ciberdem.org/annualreport CIBER
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