2010 AnnuAl REpoRT - Ciberdem

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Research grants International projects Trial to reduce IDDM in children at genetic risk. TRIGR National Institutes of Health, 5U01HD040364-08: 2007-2011 Principal Investigator: Castaño L Coordinator: Akerbloom H Associate investigators: Martul P, Bilbao JR, Rica I Centre Differences study in children aged under 11 years Hvidore Study Group on Childhood diabetes, Novo-Nordisk: 2009-2010 Principal Investigator: Castaño L Associate investigator: de Beaufort C National project Diabetes Neonatal y de comienzo precoz: Caracterización molecular y fenotipo Ministerio de Sanidad y Consumo-ISCIII, PS09/01492: 2010-2012 Principal Investigator: Castaño L Associate investigators: Fernández Ramos C, Busturia MA, Rica I, Martínez R, Rodríguez A, Blarduni E, Chueca M, Oyarzabal M Autonomous Community projects Etiopatogenia de los trastornos autoinmunes: Diabetes mellitus tipo 1 y Enfermedad Celiaca Departamento de Educación - Gobierno Vasco, IT-472-07: 2007-2012 Principal Investigator: Castaño L Associate investigators: Vitoria JC, Gaztambide S, Bilbao JR Epidemiología de la diabetes en el Pais Vasco Departamento de Sanidad y Consumo - Gobierno Vasco, 2009COM11: 2009-2010 Principal Investigator: Castaño L Associate investigator: Gaztambide S Encapsulación de islotes pancreáticos de ratón: Análisis de la funcionalidad y revascularización in vitro e in vivo Departamento de Industria - Gobierno Vasco, SAIO09- PE09BF01: 2009-2010 Principal Investigator: Castaño L Associate investigators: Ramírez M, Vázquez F, Pérez de Nanclares G Scientific collaborations within CIBERDEM Clinical, genetic and functional characterization of monogenic diabetes: from the bench to the bedside MODIAB: 2009-2010 Coordinator: Luis Castaño CIBERDEM groups: L Castaño, E Blázquez, J Ferrer, M Vallejo Di@bet.es Study: 1st epidemiological study of the prevalence of type 2 diabetes in Spain Coordinator: F Soriguer CIBERDEM groups: L Castaño, F Soriguer, R Carmena, R Gomis, M Serrano Ríos, J Vendrell CIBERDEM Biobank Coordinator: A Novials CIBERDEM Biobank Nodes: L Castaño, R Gomis, A Novials, J Vendrell, L Masana, M Serrano Ríos, F Soriguer, R Carmena, F Blanco Vaca Clinical trials Estudio aleatorizado, controlado frente a placebo, doble ciego, paralelo y multicéntrico para evaluar antagonistas de IL-1 en sujetos con diabetes tipo 1 de reciente diagnóstico. AIDA. Phase II B Steno Diabetes Center, EudraCT 2007-007146-34: 2009-2010 Name of the participants: Gaztambide S, Vázquez F, Moure MD, Moreno A, Gallego P Estudio multicéntrico, randomizado, abierto, doble ciego, con doble enmascaramiento, controlado frente a un comparador activo para evaluar eficacia, seguridad y tolerancia de taspoglutida comparado con pioglitazona en pacientes con diabetes mellitus tipo 2 controlados inadecuadamente con sulfonilurea (SU) en monoterapia o con la combinación metformina más sulfonilurea. Phase II B Hoffmann-La Roche, RO5073031: 2009-2010 Name of the participants: Santamaría J, Cortázar A A phase III 3 arm randomized double-blind placebo controlled multicenter study to investigate the impact of Diamyd on the progression of diabetes in patients newly diagnosed with type 1 diabetes mellitus. Phase III Diamyd Therapeutics, D/P3/07/4: 2008-2010 Name of the participants: Castaño L, Rica I European prescription survey of short acting insulin analogues in children and adolescents. EPIC Study. Phase III Sanofi-Aventis, DIREG_R_04154: 2008-2010 Name of the participant: Castaño L (steering committee member) European postmarketing observational prospective cohort study of children with type 1 diabetes treated with apidra. OCAPI Study. Phase III Sanofi-Aventis, APIDR_C_03909: 2008-2010 Name of the participant: Castaño L (steering committee member) Ensayo de fase 2, multicéntrico, en doble ciego, controlado con placebo, de grupos paralelos y aleatorizado para evaluar la eficacia hipoglucemiante, la seguridad renal, la farmacodicinética y la farmacodinámica de DAPAGLIFLOZIN en sujetos con diabetes mellitus tipo 2 e insuficiencia renal moderada con un inadecuado control glucémico. Phase II 2010 Annual Report 105
Bristol-Myers Squibb, CEIC 08/47: 2008-2010 Name of the participants: Gaztambide S, Goikolea I PhD theses Functional players in coeliac disease: identification and genetic association Author: Ainara Castellanos Rubio Thesis advisors: Bilbao JR, Castaño L University: Universidad del Pais Vasco, European thesis Thesis defense date: October 22, 2010 Awards Premio a la Investigación en Endocrinologia Pediátrica y crecimiento (2010) Institution: Fundación de la Sociedad Española de Endocrinología Pediátrica Awardees: Castaño L, Bilbao JR Premio a la mejor Comunicación Básica (2010) Institution: XII Congreso de la Sociedad de Endocrinología, Diabetes y Nutrición de Euskadi Awardees: Ramírez Domínguez M, López Euba T, Castaño L ■ 106 CibeRdem
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2010 Annual Report CIBERDEM Centro
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Letter from the Scientific Director
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Contents Prologue Research results
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Research results Publications In 20
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Project management Introduction The
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Training programme Introduction The
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Outreach activities CIBERDEM Fundra
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More about CIBERDEM The Centro de I
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Human Resources In 2010, CIBERDEM h
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Transversal projects Di@bet.es Stud
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Di@bet.es Study Introduction Attemp
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CIBERDEM Projects Introduction CIBE
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girls (girls born small for gestati
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Biobank Introduction and objectives
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Metabolomics Platform Introduction
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Area 1 Insulin signalling and resis
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Diabetes and cardiovascular Faculta
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Metabolomics Platform Universitat R
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Obesity, inflammation and insulin r
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Mechanisms of control of glucose an
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Metabolic engineering and diabetes
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Molecular mechanisms of insulin res
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Molecular characteristics, and acti
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Heterogenic and polygenic diseases.
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Principal Investigator: Antonio Zor
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The research activity of this area
Page 56 and 57: The cationic cluster of group IVA p
Page 58 and 59: agent that affects the enterohepati
Page 60 and 61: Dyslipidaemia, inflammation and end
Page 62 and 63: Daño orgánico en la diabetes mell
Page 64 and 65: Proteomic analysis of plasma in the
Page 66 and 67: Prenatal growth restriction and sub
Page 68 and 69: The effects of metformin on cardiov
Page 70 and 71: Lipids and Arteriosclerosis Researc
Page 72 and 73: Review Pitavastatin - from clinical
Page 74 and 75: Diabetobe Hospital Clínico San Car
Page 76 and 77: Scientific collaborations within CI
Page 78 and 79: Atherosclerosis, 209, 201-205 (2010
Page 80 and 81: Solvay, SA: 2008-2010 Principal Inv
Page 82 and 83: Endocrinology and Nutrition Service
Page 84 and 85: Prevención de la Diabetes mellitus
Page 86 and 87: Pharmacological targets in inflamma
Page 88 and 89: Diabetes and Metabolic Associated D
Page 90 and 91: Autonomous Community project Grup d
Page 92 and 93: Area 3 of CIBERDEM comprises thirte
Page 94 and 95: Escrivá F, Alvarez C J Mol Endocri
Page 96 and 97: Am J Physiol Endocrinol Metab, 298,
Page 98 and 99: Transgenic animal models and gene t
Page 100 and 101: Ayuso E, Mingozzi F, Bosch F Curr G
Page 102 and 103: Laboratory of Molecular Endocrinolo
Page 104 and 105: Hospital de Cruces Diabetes Researc
Page 108 and 109: Proinsulin and tyrosine hydroxilase
Page 110 and 111: Genomic programming of beta cells I
Page 112 and 113: Diabetes and obesity: biopathology
Page 114 and 115: Utilidad de la ecografía arterial
Page 116 and 117: Islet cell and stem cell physiology
Page 118 and 119: in diabetic patients with chronic c
Page 120 and 121: Liraglutide versus sitagliptin for
Page 122 and 123: Unit of Cell Physiology and Nutriti
Page 124 and 125: National projects Efectos a corto y
Page 126 and 127: Altirriba J, Gasa R, Casas S, Ramí
Page 128 and 129: Transcriptional mechanisms of pancr
Page 131 and 132: Epilogue
Page 133 and 134: Keyword index* Beta-cell signal tra
Page 135 and 136: Association of selected ABC gene fa
Page 137 and 138: Leiter LA, Levitt NS, Mareev V, Mar
Page 139 and 140: Low body adiposity and high leptine
Page 141 and 142: Alvaro A, Rosales R, Masana L, Vall
Page 143 and 144: The apolipoprotein A5 (APOA5) gene
Page 145 and 146: www.ciberdem.org/annualreport CIBER
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2010 AnnuAl REpoRT - Ciberdem

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