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2010 AnnuAl REpoRT - Ciberdem

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Proteomic analysis of plasma in the polycystic ovary<br />

syndrome identifies novel markers involved in iron<br />

metabolism, acute-phase response, and inflammation<br />

Insenser M, Martínez-García MA, Montes R, San-Millán JL,<br />

Escobar-Morreale HF<br />

J Clin Endocrinol Metab, 95, 3863-3870 (<strong>2010</strong>)<br />

IF: 6.202 first decile<br />

The determinants of insulin sensitivity, β-cell function,<br />

and glucose tolerance are different in patients with<br />

polycystic ovary syndrome than in women who do not have<br />

hyperandrogenism<br />

Luque-Ramírez M, Alpañés M, Escobar-Morreale HF<br />

Fertil Steril, 94, 2214-2221 (<strong>2010</strong>)<br />

IF: 3.970 first decile<br />

The role of genetic variation in peroxisome proliferatoractivated<br />

receptors in the polycystic ovary syndrome<br />

(PCOS): an original case-control study followed by<br />

systematic review and meta-analysis of existing evidence<br />

San-Millán JL, Escobar-Morreale HF<br />

Clin Endocrinol, 72, 383-392 (<strong>2010</strong>)<br />

IF: 3.201 second quartile<br />

frente a un anticonceptivo oral más un antiandrógeno<br />

(espironolactona). Phase II<br />

ENDOPCOS 02/2008: <strong>2010</strong>-ongoing<br />

Name of the participants: HF Escobar Morreale (coordinator<br />

and researcher), M Alpañés Buesa and M Luque Ramírez<br />

(researchers)<br />

Clinical practice guidelines<br />

Assessment of cardiovascular risk and prevention of<br />

cardiovascular disease in women with the polycystic ovary<br />

syndrome: a position statement by the Androgen Excess &<br />

Polycystic Ovary Syndrome (AE-PCOS) Society<br />

Journal of Clinical Endocrinology & Metabolism, 95, 2038-<br />

2049 (<strong>2010</strong>)<br />

Institution: Androgen Excess & Polycystic Ovary Syndrome<br />

(AE-PCOS) Society<br />

Authors: RA Wild, E Carmina, E Diamanti-Kandarakis, A<br />

Dokras, HF Escobar Morreale, W Futterweit, R Lobo, RJ<br />

Norman, E Talbott, DA Dumesic<br />

Treatment of polycystic ovary syndrome (PCOS) with<br />

metformin ameliorates insulin resistance in parallel with the<br />

decrease of serum interleukin-6 concentrations<br />

Luque-Ramírez M, Escobar-Morreale HF<br />

Horm Metab Res, 42, 815-820 (<strong>2010</strong>)<br />

IF: 2.686 second quartile<br />

Research grants<br />

National project<br />

Influencia de los andrógenos en el desarrollo de la<br />

adiposidad abdominal y de la disfunción metabólica<br />

del tejido adiposo visceral en humanos, como factores<br />

etiopatogénicos de la resistencia insulínica y la diabetes<br />

Instituto de Salud Carlos III, Fondo de Investigación<br />

Sanitaria, PI081147: 2009-2011<br />

Principal Investigator: Héctor F Escobar Morreale<br />

Scientific collaborations within CIBERDEM<br />

Determinants of insulin resistance and glucose tolerance<br />

disorders, including diabetes, in severe obesity and their<br />

changes after bariatric surgery-induced weight loss<br />

DIASOBS: 2009-<strong>2010</strong><br />

Coordinator: Héctor F Escobar Morreale<br />

CIBERDEM groups: HF Escobar Morreale, X Correig, E<br />

Montanya, R Simó, J Vendrell<br />

Clinical trials<br />

Protocolo de investigación sobre el perfil de riesgo<br />

cardiovascular asociado a mujeres con síndrome de<br />

ovario poliquístico o hiperandrogenismo ovulatorio, y<br />

evolución del mismo durante el tratamiento con metformina<br />

Representative Cy2-labelled internal standard proteome map indicating<br />

the proteins altered in PCOS. The four protein spots found<br />

significantly increased in the plasma samples from PCOS patients<br />

(P

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