2010 AnnuAl REpoRT - Ciberdem

Transcriptional mechanisms of pancreatic function
Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas,
Universidad Autónoma de Madrid
www.iib.uam.es
Principal Investigator Mario Vallejo mvallejo@iib.uam.es Postdoctoral fellows María Natacha Díaz, Mercedes Mirasierra PhD students
Patricia García, Laura Ruiz Lab manager Antonio Fernández
Total IF: 7.365
Publications: 2, 1 in the first quartile and 1 in the second quartile
Research grants: 1
National projects: 1
Scientific collaborations within CIBERDEM: 2
Keywords
Insulin synthesis. Islet degeneration and damage. Islet
development. Transcription factors.
Main lines of research
-The characterization of phenotypic alterations of
pancreatic islets in the absence of Alx3.
-The requirement of Alx3 for the maintenance of glucose
homeostasis in vivo.
-The identification of transcriptional targets regulated by Alx3.
-The determination of the expression pattern of Alx3 during
pancreas development.
-The role of Alx3 in the regulation of the development of the neural
tube and vulnerability to hyperglycaemic insult in its absence.
Publications*
Original article
Alx3-deficient mice exhibit folic acid-resistant craniofacial
midline and neural tube closure defects
Lakhwani S, García-Sanz P, Vallejo M
Dev Biol, 344, 869-880 (2010)
IF: 4.379 first quartile
Activity-dependent somatostatin gene expression is
regulated by cAMP-dependent protein kinase and Ca2+calmodulin
kinase pathways
Sánchez-Muñoz I, Sánchez-Franco F, Vallejo M, Fernández
A, Palacios N, Fernández M, Cacicedo L
J Neurosci Res, 88, 825-836 (2010)
IF: 2.986 second quartile
*Only those published in 2010, with CIBERDEM listed among the affiliations, which are related to CIBERDEM’s field of research and are
located in the first or second quartile of their subject category are included.
2010 Annual Report
127