2010 AnnuAl REpoRT - Ciberdem

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Proteomic analysis of plasma in the polycystic ovary syndrome identifies novel markers involved in iron metabolism, acute-phase response, and inflammation Insenser M, Martínez-García MA, Montes R, San-Millán JL, Escobar-Morreale HF J Clin Endocrinol Metab, 95, 3863-3870 (2010) IF: 6.202 first decile The determinants of insulin sensitivity, β-cell function, and glucose tolerance are different in patients with polycystic ovary syndrome than in women who do not have hyperandrogenism Luque-Ramírez M, Alpañés M, Escobar-Morreale HF Fertil Steril, 94, 2214-2221 (2010) IF: 3.970 first decile The role of genetic variation in peroxisome proliferatoractivated receptors in the polycystic ovary syndrome (PCOS): an original case-control study followed by systematic review and meta-analysis of existing evidence San-Millán JL, Escobar-Morreale HF Clin Endocrinol, 72, 383-392 (2010) IF: 3.201 second quartile frente a un anticonceptivo oral más un antiandrógeno (espironolactona). Phase II ENDOPCOS 02/2008: 2010-ongoing Name of the participants: HF Escobar Morreale (coordinator and researcher), M Alpañés Buesa and M Luque Ramírez (researchers) Clinical practice guidelines Assessment of cardiovascular risk and prevention of cardiovascular disease in women with the polycystic ovary syndrome: a position statement by the Androgen Excess & Polycystic Ovary Syndrome (AE-PCOS) Society Journal of Clinical Endocrinology & Metabolism, 95, 2038- 2049 (2010) Institution: Androgen Excess & Polycystic Ovary Syndrome (AE-PCOS) Society Authors: RA Wild, E Carmina, E Diamanti-Kandarakis, A Dokras, HF Escobar Morreale, W Futterweit, R Lobo, RJ Norman, E Talbott, DA Dumesic Treatment of polycystic ovary syndrome (PCOS) with metformin ameliorates insulin resistance in parallel with the decrease of serum interleukin-6 concentrations Luque-Ramírez M, Escobar-Morreale HF Horm Metab Res, 42, 815-820 (2010) IF: 2.686 second quartile Research grants National project Influencia de los andrógenos en el desarrollo de la adiposidad abdominal y de la disfunción metabólica del tejido adiposo visceral en humanos, como factores etiopatogénicos de la resistencia insulínica y la diabetes Instituto de Salud Carlos III, Fondo de Investigación Sanitaria, PI081147: 2009-2011 Principal Investigator: Héctor F Escobar Morreale Scientific collaborations within CIBERDEM Determinants of insulin resistance and glucose tolerance disorders, including diabetes, in severe obesity and their changes after bariatric surgery-induced weight loss DIASOBS: 2009-2010 Coordinator: Héctor F Escobar Morreale CIBERDEM groups: HF Escobar Morreale, X Correig, E Montanya, R Simó, J Vendrell Clinical trials Protocolo de investigación sobre el perfil de riesgo cardiovascular asociado a mujeres con síndrome de ovario poliquístico o hiperandrogenismo ovulatorio, y evolución del mismo durante el tratamiento con metformina Representative Cy2-labelled internal standard proteome map indicating the proteins altered in PCOS. The four protein spots found significantly increased in the plasma samples from PCOS patients (P
Meta-analysis of the mean difference in fasting insulin levels among carriers of the PPAR-γ2 Pro12Ala variant compared with PPAR-γ2 Reproduced from San-Mill‡ n & Escobar-Morreale. Clinical Endocrinology 72:383-392 (2010), with permission from the Authors. Pro12Pro subjects considering PCOS patients and controls as a whole. CI, confidence interval; ID, identification; MD, mean difference. Image from: Clin Endocrinol, 2010 ■ 64 CibeRdem
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2010 Annual Report CIBERDEM Centro
Page 4 and 5:
Letter from the Scientific Director
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Contents Prologue Research results
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Research results Publications In 20
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Project management Introduction The
Page 12 and 13:
Training programme Introduction The
Page 14 and 15: Outreach activities CIBERDEM Fundra
Page 16 and 17: More about CIBERDEM The Centro de I
Page 18 and 19: Human Resources In 2010, CIBERDEM h
Page 20 and 21: Transversal projects Di@bet.es Stud
Page 22 and 23: Di@bet.es Study Introduction Attemp
Page 24 and 25: CIBERDEM Projects Introduction CIBE
Page 26 and 27: girls (girls born small for gestati
Page 28 and 29: Biobank Introduction and objectives
Page 30 and 31: Metabolomics Platform Introduction
Page 33 and 34: Area 1 Insulin signalling and resis
Page 35 and 36: Diabetes and cardiovascular Faculta
Page 37 and 38: Metabolomics Platform Universitat R
Page 39 and 40: Obesity, inflammation and insulin r
Page 41 and 42: Mechanisms of control of glucose an
Page 43 and 44: Metabolic engineering and diabetes
Page 45 and 46: Molecular mechanisms of insulin res
Page 47 and 48: Molecular characteristics, and acti
Page 49 and 50: Heterogenic and polygenic diseases.
Page 51: Principal Investigator: Antonio Zor
Page 54 and 55: The research activity of this area
Page 56 and 57: The cationic cluster of group IVA p
Page 58 and 59: agent that affects the enterohepati
Page 60 and 61: Dyslipidaemia, inflammation and end
Page 62 and 63: Daño orgánico en la diabetes mell
Page 66 and 67: Prenatal growth restriction and sub
Page 68 and 69: The effects of metformin on cardiov
Page 70 and 71: Lipids and Arteriosclerosis Researc
Page 72 and 73: Review Pitavastatin - from clinical
Page 74 and 75: Diabetobe Hospital Clínico San Car
Page 76 and 77: Scientific collaborations within CI
Page 78 and 79: Atherosclerosis, 209, 201-205 (2010
Page 80 and 81: Solvay, SA: 2008-2010 Principal Inv
Page 82 and 83: Endocrinology and Nutrition Service
Page 84 and 85: Prevención de la Diabetes mellitus
Page 86 and 87: Pharmacological targets in inflamma
Page 88 and 89: Diabetes and Metabolic Associated D
Page 90 and 91: Autonomous Community project Grup d
Page 92 and 93: Area 3 of CIBERDEM comprises thirte
Page 94 and 95: Escrivá F, Alvarez C J Mol Endocri
Page 96 and 97: Am J Physiol Endocrinol Metab, 298,
Page 98 and 99: Transgenic animal models and gene t
Page 100 and 101: Ayuso E, Mingozzi F, Bosch F Curr G
Page 102 and 103: Laboratory of Molecular Endocrinolo
Page 104 and 105: Hospital de Cruces Diabetes Researc
Page 106 and 107: Research grants International proje
Page 108 and 109: Proinsulin and tyrosine hydroxilase
Page 110 and 111: Genomic programming of beta cells I
Page 112 and 113: Diabetes and obesity: biopathology
Page 114 and 115:
Utilidad de la ecografía arterial
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Islet cell and stem cell physiology
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in diabetic patients with chronic c
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Liraglutide versus sitagliptin for
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Unit of Cell Physiology and Nutriti
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National projects Efectos a corto y
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Altirriba J, Gasa R, Casas S, Ramí
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Transcriptional mechanisms of pancr
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Epilogue
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Keyword index* Beta-cell signal tra
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Association of selected ABC gene fa
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Leiter LA, Levitt NS, Mareev V, Mar
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Low body adiposity and high leptine
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Alvaro A, Rosales R, Masana L, Vall
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The apolipoprotein A5 (APOA5) gene
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2010 AnnuAl REpoRT - Ciberdem

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