2010 AnnuAl REpoRT - Ciberdem

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The research activity of this area is focused on the study of dyslipidaemias, metabolic syndrome and diabetic microvascular complications. The area comprises a total of 11 research groups and includes both basic and clinical researchers. The aim is to generate traslational collaborative research, ranging from epidemiological studies, and a global therapeutic approach to diabetes and its complications, reaching into the area of genetic studies and the search for new biomarkers of cardiovascular risk in diabetic subjects. During the year 2010, the groups included in Area 2 published a total of 59 scientific papers; 22 of them were published in journals in the first decile of the speciality. The accumulated Impact Factor (IF) for this period was 268.13. It is important to emphasize that 9 papers were the result of collaborations between CIBERDEM research groups, and an additional 21 papers were the result of working collaborations with other groups included in different CIBER programmes. Furthermore, groups from Area 2 were successful in obtaining 60 competitive research grants to fund their respective research projects. Thirty of these were grants awarded jointly to different CIBERDEM groups. In relation to other scientific activities in Area 2 during 2010, a total of 27 clinical research trials were conducted and 9 doctoral theses supervised by investigators in the Area were defended. Finally, the results of research activities were transferred to clinical practice, with 3 new clinical guidelines being published, but there were also other important outcomes, such as the registration of a patent and the generation of a spin-off. Rafael Carmena CIBERDEM Scientific Area Coordinator 2010 Annual Report 53
The Eicosanoid Research Division Instituto de Biología y Genética Molecular, Consejo Superior de Investigaciones Científicas, Valladolid www.balsinde.org Principal Investigator Jesús Balsinde jbalsinde@ibgm.uva.es Associate researchers María Ángeles Balboa, Olimpio Montero Postdoctoral fellows Clara Meana, Julio Rubio PhD students Alma Astudillo, Esperanza Esquinas, Luis Gil de Gómez, Lucía Peña, Martín Valdearcos Lab managers Montserrat Duque, Yolanda Sáez Lab technician David Balgoma Total IF: 20.106 Publications: 4, 3 of them in the first quartile and 1 in the second quartile Research grants: 5 National projects: 2 Autonomous Community projects: 3 Scientific collaborations within CIBERDEM: 1 Keywords Cytokines. Lipid metabolism. Lipid signalling. Metabolic syndrome. Phospholipases. Main lines of research -Lipid metabolic pathways in obesity and inflammation. -The molecular and cell biology of lipid droplets. -Lipidomics and metabolipidomics: characterization of cellular lipidomes and lipid pathways by mass spectrometry. -Cellular utilization of free fatty acids: acylation and transacylation mechanisms. Publications* Original articles Markers of monocyte activation revealed by lipidomic profiling of arachidonic acid-containing phospholipids Balgoma D, Astudillo AM, Pérez-Chacón G, Montero O, Balboa MA, Balsinde J J Immunol, 184, 3857-3865 (2010) IF: 5.646 first quartile Signaling role for lysophosphatidylcholine acyltransferase 3 in receptor-regulated arachidonic acid reacylation reactions in human monocytes Pérez-Chacón G, Astudillo AM, Ruipérez V, Balboa MA, Balsinde J J Immunol, 184, 1071-1078 (2010) IF: 5.646 first quartile *Only those published in 2010, with CIBERDEM listed among the affiliations, which are related to CIBERDEM’s field of research and are located in the first or second quartile of their subject category are included. 54 CibeRdem
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2010 Annual Report CIBERDEM Centro
Page 4 and 5: Letter from the Scientific Director
Page 6 and 7: Contents Prologue Research results
Page 8 and 9: Research results Publications In 20
Page 10 and 11: Project management Introduction The
Page 12 and 13: Training programme Introduction The
Page 14 and 15: Outreach activities CIBERDEM Fundra
Page 16 and 17: More about CIBERDEM The Centro de I
Page 18 and 19: Human Resources In 2010, CIBERDEM h
Page 20 and 21: Transversal projects Di@bet.es Stud
Page 22 and 23: Di@bet.es Study Introduction Attemp
Page 24 and 25: CIBERDEM Projects Introduction CIBE
Page 26 and 27: girls (girls born small for gestati
Page 28 and 29: Biobank Introduction and objectives
Page 30 and 31: Metabolomics Platform Introduction
Page 33 and 34: Area 1 Insulin signalling and resis
Page 35 and 36: Diabetes and cardiovascular Faculta
Page 37 and 38: Metabolomics Platform Universitat R
Page 39 and 40: Obesity, inflammation and insulin r
Page 41 and 42: Mechanisms of control of glucose an
Page 43 and 44: Metabolic engineering and diabetes
Page 45 and 46: Molecular mechanisms of insulin res
Page 47 and 48: Molecular characteristics, and acti
Page 49 and 50: Heterogenic and polygenic diseases.
Page 51: Principal Investigator: Antonio Zor
Page 56 and 57: The cationic cluster of group IVA p
Page 58 and 59: agent that affects the enterohepati
Page 60 and 61: Dyslipidaemia, inflammation and end
Page 62 and 63: Daño orgánico en la diabetes mell
Page 64 and 65: Proteomic analysis of plasma in the
Page 66 and 67: Prenatal growth restriction and sub
Page 68 and 69: The effects of metformin on cardiov
Page 70 and 71: Lipids and Arteriosclerosis Researc
Page 72 and 73: Review Pitavastatin - from clinical
Page 74 and 75: Diabetobe Hospital Clínico San Car
Page 76 and 77: Scientific collaborations within CI
Page 78 and 79: Atherosclerosis, 209, 201-205 (2010
Page 80 and 81: Solvay, SA: 2008-2010 Principal Inv
Page 82 and 83: Endocrinology and Nutrition Service
Page 84 and 85: Prevención de la Diabetes mellitus
Page 86 and 87: Pharmacological targets in inflamma
Page 88 and 89: Diabetes and Metabolic Associated D
Page 90 and 91: Autonomous Community project Grup d
Page 92 and 93: Area 3 of CIBERDEM comprises thirte
Page 94 and 95: Escrivá F, Alvarez C J Mol Endocri
Page 96 and 97: Am J Physiol Endocrinol Metab, 298,
Page 98 and 99: Transgenic animal models and gene t
Page 100 and 101: Ayuso E, Mingozzi F, Bosch F Curr G
Page 102 and 103: Laboratory of Molecular Endocrinolo
Page 104 and 105:
Hospital de Cruces Diabetes Researc
Page 106 and 107:
Research grants International proje
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Proinsulin and tyrosine hydroxilase
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Genomic programming of beta cells I
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Diabetes and obesity: biopathology
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Utilidad de la ecografía arterial
Page 116 and 117:
Islet cell and stem cell physiology
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in diabetic patients with chronic c
Page 120 and 121:
Liraglutide versus sitagliptin for
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Unit of Cell Physiology and Nutriti
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National projects Efectos a corto y
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Altirriba J, Gasa R, Casas S, Ramí
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Transcriptional mechanisms of pancr
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Epilogue
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Keyword index* Beta-cell signal tra
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Association of selected ABC gene fa
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Leiter LA, Levitt NS, Mareev V, Mar
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Low body adiposity and high leptine
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Alvaro A, Rosales R, Masana L, Vall
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The apolipoprotein A5 (APOA5) gene
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www.ciberdem.org/annualreport CIBER
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2010 AnnuAl REpoRT - Ciberdem

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