2010 AnnuAl REpoRT - Ciberdem
2010 AnnuAl REpoRT - Ciberdem
2010 AnnuAl REpoRT - Ciberdem
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Endocrinology and metabolism<br />
Departamento de Bioquímica y Biología Molecular II, Facultad de Farmacia, Universidad Complutense de Madrid<br />
www.ucm.es/info/biomol2<br />
Principal Investigator Carmen Álvarez calvarez@farm.ucm.es Associate researchers Fernando Escrivá, María Ángeles Martín<br />
Postdoctoral fellow Elisa Fernández PhD student Juan de Toro Lab technician Esther Lizárraga<br />
Total IF: 7.807<br />
Publications: 2, 1 in the first quartile and 1 in the second quartile<br />
With other CIBERDEM groups: 1<br />
With other international groups: 1<br />
Research grants: 3<br />
National projects: 2<br />
Autonomous Community projects: 1<br />
Scientific collaborations within CIBERDEM: 1<br />
PhD theses: 1<br />
Keywords<br />
Islet degeneration and damage. Beta-cell signal transduction.<br />
Insulin action. Insulin sensitivity and resistance. Gastroentero<br />
pancreatic factors.<br />
Main lines of research<br />
The identification of the cellular and molecular mechanisms<br />
that link poor perinatal growth and increased risk of obesity<br />
and type 2 diabetes in adult life through the use of animal<br />
models of nutritional manipulation: maternal undernutrition<br />
followed or not by overnutrition, focused on:<br />
a) the effects of nutrients on the development, growth<br />
and death of pancreatic islet-cells and the implication<br />
of the IGFs.<br />
b) insulin/glucagon signalling pathways in both peripheral<br />
and central tissues: liver, cortex and hypothalamus.<br />
c) the possible alterations of hypothalamic response to<br />
leptin associated with under/overnutrition.<br />
d) the potential role of incretins in the relationship between<br />
intrauterine growth restriction and the development of<br />
glucose intolerance.<br />
Publications*<br />
Original articles<br />
Maternal undernutrition increases pancreatic IGF-2 and<br />
partially suppresses the physiological wave of {beta}-cell<br />
apoptosis during the neonatal period<br />
de Miguel-Santos L, Fernández-Millán E, Angeles Martín M,<br />
*Only those published in <strong>2010</strong>, with CIBERDEM listed among the affiliations, which are related to CIBERDEM’s field of research and are<br />
located in the first or second quartile of their subject category are included.<br />
92 CibeRdem
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