2010 AnnuAl REpoRT - Ciberdem

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Dyslipidaemia, inflammation and endothelial dysfunction Servicio de Endocrinología y Nutrición, Fundación Investigación Hospital Clínico Universitario de Valencia www.fihcuv.es Principal Investigator Rafael Carmena rafael.carmena@uv.es Associate researchers Juan Francisco Ascaso, Miguel Catalá, Felipe Javier Chaves, Sergio Martínez Hervás, José Tomás Real Postdoctoral fellows Ana Bárbara García, Marta Peiró Lab manager Sebastián Blesa Lab technicians Esther Benito, Clara María Bixquert, Nieves Brito, Griselda de Marco Total IF: 17.452 Publications: 5, 1 of them in the first decile, 2 in the first quartile and 2 in the second quartile With other CIBERDEM groups: 1 With other CIBERs: 4 Research grants: 3 National projects: 2 Autonomous Community projects: 1 Scientific collaborations within CIBERDEM: 4 PhD theses: 1 Keywords Insulin sensitivity and resistance. Lipid metabolism. Macrovascular disease. Metabolic syndrome. Weight regulation and obesity. Main lines of research The degree of arterial damage and age of onset of arteriosclerosis varies in patients with primary dyslipidaemias or diabetes, indicating the existence of other contributing factors. We have investigated the role of oxidative stress (OS), inflammation, insulin resistance, and prediabetic states as possible candidates. Our research lines include: primary hyperlipidaemias - genetic diagnosis and cardiovascular risk; primary mixed hyperlipidaemias - insulin resistance and diabetes mellitus; postprandial lipidaemia and arteriosclerosis in insulin-resistant states; insulin resistance, inflammation and oxidative stress; diabetic foot - diagnosis, prevention and treatment; and genetic factors regulating BMI and abdominal obesity. Publications* Original articles Association of selected ABC gene family single nucleotide polymorphisms with postprandial lipoproteins: results from *Only those published in 2010, with CIBERDEM listed among the affiliations, which are related to CIBERDEM’s field of research and are located in the first or second quartile of their subject category are included. 2010 Annual Report 59
the population-based Hortega study Abellán R, Mansego ML, Martínez-Hervás S, Martín- Escudero JC, Carmena R, Real JT, Redon J, Castrodeza- Sanz JJ, Chaves FJ Atherosclerosis, 211, 203-209 (2010) IF: 4.522 first decile. With other CIBERs: CIBEROBN Circulating mononuclear cells nuclear factor-kappa B activity, plasma xanthine oxidase, and low grade inflammatory markers in adult patients with familial hypercholesterolaemia Real JT, Martínez-Hervás S, García-García AB, Civera M, Pallardó FV, Ascaso JF, Viña JR, Chaves FJ, Carmena R Eur J Clin Invest, 40, 89-94 (2010) IF: 2.643 first quartile. With other CIBERs: CIBERER FABP4 plasma levels are increased in familial combined hyperlipidemia Cabré A, Lázaro I, Cofán M, Jarauta E, Plana N, Garcia-Otín AL, Ascaso JF, Ferré R, Civeira F, Ros E, Masana L J Lipid Res, 51, 1173-1178 (2010) IF: 4.917 first quartile. With other CIBERDEM groups: L Masana. With other CIBERs: CIBEROBN How ineffective hypertension control in subjects treated with angiotensin-converting enzyme inhibitors is related to polymorphisms in the renin-angiotensin-aldosterone system Morales-Suárez-Varela MM, Mansego ML, Martín-Escudero JC, Llopis-González A, Chaves FJ, López-Izquierdo R, Frutos-Llanes R, Vicedo-Cabrera AM Eur J Pharm Sci, 39, 380-386 (2010) IF: 2.608 second quartile. With other CIBERs: CIBERESP, CIBEROBN Plasma homocysteine levels are associated with ulceration of the foot in patients with type 2 diabetes mellitus González R, Pedro T, Real JT, Martínez-Hervás S, Abellán MR, Lorente R, Priego A, Catalá M, Chaves FJ, Ascaso JF, Carmena R Diabetes Metab Res Rev, 26, 115-120 (2010) IF: 2.762 second quartile Book chapter Book: Endocrinología, Editorial Panamericana, Madrid (2010) Chapter: Dislipemias. Metabolismo lipídico. Authors: Ascaso JF, Martínez-Hervás S Pages: 1075-1086 Research grants National projects CAIBER de Unidades Centrales de Investigación Clínica y en Ensayos Clínicos Instituto de Salud Carlos III, CAI08/01/0039: 2010 Principal Investigator: Andrés Cervantes Associate investigator: Rafael Carmena Scanning microarrays. 60 CibeRdem
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2010 Annual Report CIBERDEM Centro
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Letter from the Scientific Director
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Contents Prologue Research results
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Research results Publications In 20
Page 10 and 11: Project management Introduction The
Page 12 and 13: Training programme Introduction The
Page 14 and 15: Outreach activities CIBERDEM Fundra
Page 16 and 17: More about CIBERDEM The Centro de I
Page 18 and 19: Human Resources In 2010, CIBERDEM h
Page 20 and 21: Transversal projects Di@bet.es Stud
Page 22 and 23: Di@bet.es Study Introduction Attemp
Page 24 and 25: CIBERDEM Projects Introduction CIBE
Page 26 and 27: girls (girls born small for gestati
Page 28 and 29: Biobank Introduction and objectives
Page 30 and 31: Metabolomics Platform Introduction
Page 33 and 34: Area 1 Insulin signalling and resis
Page 35 and 36: Diabetes and cardiovascular Faculta
Page 37 and 38: Metabolomics Platform Universitat R
Page 39 and 40: Obesity, inflammation and insulin r
Page 41 and 42: Mechanisms of control of glucose an
Page 43 and 44: Metabolic engineering and diabetes
Page 45 and 46: Molecular mechanisms of insulin res
Page 47 and 48: Molecular characteristics, and acti
Page 49 and 50: Heterogenic and polygenic diseases.
Page 51: Principal Investigator: Antonio Zor
Page 54 and 55: The research activity of this area
Page 56 and 57: The cationic cluster of group IVA p
Page 58 and 59: agent that affects the enterohepati
Page 62 and 63: Daño orgánico en la diabetes mell
Page 64 and 65: Proteomic analysis of plasma in the
Page 66 and 67: Prenatal growth restriction and sub
Page 68 and 69: The effects of metformin on cardiov
Page 70 and 71: Lipids and Arteriosclerosis Researc
Page 72 and 73: Review Pitavastatin - from clinical
Page 74 and 75: Diabetobe Hospital Clínico San Car
Page 76 and 77: Scientific collaborations within CI
Page 78 and 79: Atherosclerosis, 209, 201-205 (2010
Page 80 and 81: Solvay, SA: 2008-2010 Principal Inv
Page 82 and 83: Endocrinology and Nutrition Service
Page 84 and 85: Prevención de la Diabetes mellitus
Page 86 and 87: Pharmacological targets in inflamma
Page 88 and 89: Diabetes and Metabolic Associated D
Page 90 and 91: Autonomous Community project Grup d
Page 92 and 93: Area 3 of CIBERDEM comprises thirte
Page 94 and 95: Escrivá F, Alvarez C J Mol Endocri
Page 96 and 97: Am J Physiol Endocrinol Metab, 298,
Page 98 and 99: Transgenic animal models and gene t
Page 100 and 101: Ayuso E, Mingozzi F, Bosch F Curr G
Page 102 and 103: Laboratory of Molecular Endocrinolo
Page 104 and 105: Hospital de Cruces Diabetes Researc
Page 106 and 107: Research grants International proje
Page 108 and 109: Proinsulin and tyrosine hydroxilase
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Genomic programming of beta cells I
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Diabetes and obesity: biopathology
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Utilidad de la ecografía arterial
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Islet cell and stem cell physiology
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in diabetic patients with chronic c
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Liraglutide versus sitagliptin for
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Unit of Cell Physiology and Nutriti
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National projects Efectos a corto y
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Altirriba J, Gasa R, Casas S, Ramí
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Transcriptional mechanisms of pancr
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Epilogue
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Keyword index* Beta-cell signal tra
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Association of selected ABC gene fa
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Leiter LA, Levitt NS, Mareev V, Mar
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Low body adiposity and high leptine
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Alvaro A, Rosales R, Masana L, Vall
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The apolipoprotein A5 (APOA5) gene
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www.ciberdem.org/annualreport CIBER
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2010 AnnuAl REpoRT - Ciberdem

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