2010 AnnuAl REpoRT - Ciberdem

Islet cell and stem cell physiology
Universidad Pablo de Olavide, Centro Andaluz de Biología Molecular y Medicina Regenerativa, Sevilla
www.cabimer.es
Principal Investigator Franz Martín fmarber@upo.es Associate researchers Francisco Bedoya, Genoveva Berná, Gladys Cahuana,
Remedios Ramírez, Bernat Soria, Juan Tejedo Postdoctoral fellows Anabel Rojas, Ángeles de la Torre Ortega PhD student Manuel
Carrasco Lab technicians Raquel Araujo, Irene Díaz Contreras, Antonio Cárdenas, Ana Belén Hitos, Sergio Mora
Total IF: 14.219
Publications: 3, 1 of them in the first decile and 2 in the first quartile
With other CIBERDEM groups: 1
With other international groups: 1
Research grants: 9
National projects: 5
Autonomous Community projects: 4
Scientific collaborations within CIBERDEM: 1
Clinical trials: 4
Patents: 1
-The role of NO in embryonic stem cell differentiation and
survival.
-Transcriptional network operating during pancreas
development.
-The differentiation of human embryonic stem cells (hESCs)
to beta-cell like.
-The obtention of IPS and differentiation to beta-cell like.
-The role of endothelial factors in adult islet-cell proliferation.
-The regulation of beta-cell survival.
-Clinical trials for diabetes complications.
Keywords
Beta-cell signal transduction. Islet degeneration and
damage. Islet development. Stem cells. Clinical trial.
Main lines of research
-The study of interactive pathways implicated in «stemness».
Publications*
Original articles
Direct transcriptional regulation of Gata4 during early
endoderm specification is controlled by FoxA2 binding to
an intronic enhancer
Rojas A, Schachterle W, Xu SM, Martín F, Black BL
*Only those published in 2010, with CIBERDEM listed among the affiliations, which are related to CIBERDEM’s field of research and are
located in the first or second quartile of their subject category are included.
2010 Annual Report
115