DISPATCHESFigure 2. Interaction of hemagglutinin (HA) of H3-P99 (panels B and E) and H10-JD346 (panels C, F, and G) isolates of influenzaA(H10N8) viruses with human trachea. Sections from 2 persons are shown (A–C and D–G). A and D, negative control staining(secondary antibody without HA). Blue indicates nuclei stained with 4’,6-diamidino-2-phenylindole; green indicates HA binding.Scale bars indicate 25 µm.mutation is associated with mammal adaptation (1). Thisfinding highlights the need for an efficient surveillancenetwork to track and identify possible changes, as well asextensive research to identify them and understand theirfunctional consequences.AcknowledgmentsWe thank CFG for providing reagents. Some of the data will bepublished on the CFG website (http://www.functionalglycomics.org/). We also thank the Flow Cytometry Shared Facility and theMicroscopy Core Facility at Icahn School of Medicine at MountSinai for assistance, the Icahn School of Medicine InstitutionalBiorepository for providing human tissue sections, John Steeland Randy A. Albrecht for providing recombinant influenza viruses,and GISAID for making H10N7 and H10N8 subtype virussequencing data publicly available.This study was supported by the National Institutes of Health/National Institute of Allergy and Infectious Diseases (Centerfor Research on Influenza Pathogenesis, contract HH-SN272201400008C to J.A.R., F.K., and A.F.-S.) as part of theCenters for Excellence for Influenza Research and SurveillanceNetwork. I.R. was partially supported by National Institutes ofHealth training grant T32 AI788926.Dr. Ramos is an assistant professor in the Department of Microbiologyat the Icahn School of Medicine at Mount Sinai, New York,NY. Her main research interests focus on receptors for influenzaviruses and innate immunity to these viruses.References1. Chen H, Yuan H, Gao R, Zhang J, Wang D, Xiong Y, et al.Clinical and epidemiological characteristics of a fatal case of avianinfluenza A H10N8 virus infection: a descriptive study. Lancet.2014;383:714–21.2. Zhang W, Wan J, Qian K, Liu X, Xiao Z, Sun J, et al.Clinical characteristics of human infection with a novelavian-origin influenza A(H10N8) virus. Chin Med J (Engl).2014;127:3238–42.3. Neumann G, Kawaoka Y. Host range restriction and pathogenicityin the context of influenza pandemic. Emerg Infect Dis. 2006;12:881–6. http://dx.doi.org/10.3201/eid1206.0513364. Tumpey TM, Maines TR, Van Hoeven N, Glaser L, Solorzano A,Pappas C, et al. A two-amino acid change in the hemagglutininof the 1918 influenza virus abolishes transmission. Science.2007;315:655–9. http://dx.doi.org/10.1126/science.11362125. Zohari S, Neimanis A, Harkonen T, Moraeus C, Valarcher JF.Avian influenza A(H10N7) virus involvement in mass mortality ofharbour seals (Phoca vitulina) in Sweden, March through October2014. Euro Surveill. 2014;19:pii:20967.6. Watanabe T, Kiso M, Fukuyama S, Nakajima N, Imai M,Yamada S, et al. Characterization of H7N9 influenza A virusesisolated from humans. Nature. 2013;501:551–5. http://dx.doi.org/10.1038/nature123927. Skehel JJ, Wiley DC. Receptor binding and membrane fusion invirus entry: the influenza hemagglutinin. Annu Rev Biochem.2000;69:531–69. http://dx.doi.org/10.1146/annurev.biochem.69.1.5318. Vachieri SG, Xiong X, Collins PJ, Walker PA, Martin SR,Haire LF, et al. Receptor binding by H10 influenza viruses. Nature.2014;511:475–7. http://dx.doi.org/10.1038/nature134439. Ramos I, Bernal-Rubio D, Durham N, Belicha-Villanueva A,Lowen AC, Steel J, et al. Effects of receptor binding specificityof avian influenza virus on the human innate immune response.J Virol. 2011;85:4421–31. http://dx.doi.org/10.1128/JVI.02356-101200 Emerging Infectious Diseases • www.cdc.gov/eid • Vol. 21, No. 7, July 2015
Receptor Binding of Influenza A(H10N8) Virus10. Ramos I, Krammer F, Hai R, Aguilera D, Bernal-Rubio D, Steel J, etal. H7N9 influenza viruses interact preferentially with alpha2,3-linkedsialic acids and bind weakly to alpha2,6-linked sialic acids. J GenVirol. 2013 94:2417–23. http://dx.doi.org/ 10.1099/vir.0.056184-011. Krammer F, Margine I, Tan GS, Pica N, Krause JC, Palese P.A carboxy-terminal trimerization domain stabilizes conformationalepitopes on the stalk domain of soluble recombinant hemagglutininsubstrates. PLoS ONE. 2012;7:e43603. http://dx.doi.org/10.1371/journal.pone.004360312. Tharakaraman K, Jayaraman A, Raman R, Viswanathan K,Stebbins NW, Johnson D, et al. Glycan receptor binding of theinfluenza A virus H7N9 hemagglutinin. Cell. 2013;153:1486–93.http://dx.doi.org/10.1016/j.cell.2013.05.03413. Yang H, Carney PJ, Chang JC, Villanueva JM, Stevens J.Structure and receptor binding preferences of recombinanthemagglutinins from avian and human H6 and H10 influenza Avirus subtypes. J Virol. 2015 Feb 11;pii: JVI.03456-14.http://dx.doi.org/10.1016/j.virol.2014.12.02414. Wang M, Zhang W, Qi J, Wang F, Zhou J, Bi Y, et al. Structuralbasis for preferential avian receptor binding by the human-infectingH10N8 avian influenza virus. Nat Commun. 2015;6:5600.http://dx.doi.org/10.1038/ncomms660015. Beare AS, Webster RG. Replication of avian influenza viruses inhumans. Arch Virol. 1991;119:37–42. http://dx.doi.org/10.1007/BF01314321Address for correspondence: Irene Ramos, Department ofMicrobiology, Icahn School of Medicine at Mount Sinai, 1468Madison Ave, Box 1124, New York, NY 10029, USA;email: irene.ramos-lopez@mssm.edu; or Florian Krammer,Department of Microbiology, Icahn School of Medicine at MountSinai, 1 Gustave L. Levy Pl, Box 1124, New York, NY 10029, USA;email: florian.krammer@mssm.eduMarch 2015: TuberculosisIncluding:• Evaluation of the Benefits and Risks ofIntroducing Ebola Community Care Centers,Sierra Leone• Nanomicroarray and MultiplexNext-Generation Sequencing forSimultaneous Identification andCharacterization of Influenza Viruses• Multidrug-Resistant Tuberculosis in Europe,2010–2011• Risk Factors for Death from InvasivePneumococcal Disease, Europe, 2010• Mycoplasma pneumoniae and Chlamydiaspp. Infection in Community-AcquiredPneumonia, Germany, 2011–2012• Epidemiology of Human Mycobacteriumbovis Disease, California, USA, 2003–2011• Regional Spread of Ebola Virus, West Africa,2014• Spillover of Mycobacterium bovis fromWildlife to Livestock, South Africa• Prisons as Reservoir for CommunityTransmission of Tuberculosis, Brazil• Polycystic Echinococcosis in Pacas, AmazonRegion, Peru• Red Deer as Maintenance Host for BovineTuberculosis, Alpine Regionhttp://wwwnc.cdc.gov/eid/articles/issue/21/3/table-of-contentsEmerging Infectious Diseases • www.cdc.gov/eid • Vol. 21, No. 7, July 2015 1201
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July 2015SynopsisOn the CoverMarian
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1240 Gastroenteritis OutbreaksCause
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SYNOPSISDisseminated Infections wit
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Disseminated Infections with Talaro
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Disseminated Infections with Talaro
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Macacine Herpesvirus 1 inLong-Taile
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Malaria among Young Infants, Africa
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Transdermal Diagnosis of MalariaUsi
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Lack of Transmission amongClose Con
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Parechovirus Genotype 3 Outbreakamo
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ANOTHER DIMENSIONThe Past Is Never
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LETTERSInfluenza A(H5N6)Virus Reass
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BOOKS AND MEDIAin the port cities o
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ABOUT THE COVERNorth was not intere
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Earning CME CreditTo obtain credit,
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