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Presenting the ongoing challengesthat emerging microbial threatspose to global health
SYNOPSISDisseminated Infections withTalaromyces marneffei inNon-AIDS Patients GivenMonoclonal Antibodies againstCD20 and Kinase InhibitorsJasper F.W. Chan, Thomas S.Y. Chan, Harinder Gill, Frank Y.F. Lam, Nigel J. Trendell-Smith,Siddharth Sridhar, Herman Tse, Susanna K.P. Lau, Ivan F.N. Hung, Kwok-Yung Yuen, Patrick C.Y. WooMedscape, LLC is pleased to provide online continuing medical education (CME) for this journal article, allowingclinicians the opportunity to earn CME credit.This activity has been planned and implemented in accordance with the Essential Areas and policies of theAccreditation Council for Continuing Medical Education through the joint providership of Medscape, LLC andEmerging Infectious Diseases. Medscape, LLC is accredited by the ACCME to provide continuing medical educationfor physicians.Medscape, LLC designates this Journal-based CME activity for a maximum of 1.0 AMA PRA Category 1Credit(s) TM . Physicians should claim only the credit commensurate with the extent of their participation in the activity.All other clinicians completing this activity will be issued a certificate of participation. To participate in this journalCME activity: (1) review the learning objectives and author disclosures; (2) study the education content; (3) take thepost-test with a 75% minimum passing score and complete the evaluation at http://www.medscape.org/journal/eid; (4)view/print certificate.Release date: June 15, 2015; Expiration date: June 15, 2016Learning ObjectivesUpon completion of this activity, participants will be able to:1. Distinguish the clinical and epidemiologic characteristics of T. marneffei infection, based on a caseseries report2. Discuss the recent emergence of disseminated T. marneffei infection in non-AIDS patients withhematologic malignant neoplasms treated with targeted therapies3. Identify possible mechanisms of action underlying disseminated T. marneffei infection in non-AIDSpatients with hematologic malignant neoplasms treated with targeted therapiesCME EditorThomas J. Gryczan, MS, Technical Writer/Editor, Emerging Infectious Diseases. Disclosure: Thomas J. Gryczan,MS, has disclosed no relevant financial relationships.CME AuthorLaurie Barclay, MD, freelance writer and reviewer, Medscape, LLC. Disclosure: Laurie Barclay, MD, has disclosedno relevant financial relationships.AuthorsDisclosures: Harinder Gill, MBBS; Frank Y.F. Lam, MBBS, MRCP(UK), FHKAM; Nigel J. Trendell-Smith, MBBS,FRCPath; Siddharth Sridhar, MBBS, MRCP(UK); Herman Tse, MBBS; Susanna K.P. Lau, MD; and Kwok-YungYuen, MD, have disclosed no relevant financial relationships. Jasper F.W. Chan, MBBS, FRCPath, FRCP(Edin),has disclosed the following relevant financial relationships: received travel grants from Pfizer Co. HK Ltd. and AstellasPharma HK Co. Ltd. Thomas S.Y. Chan, MBBS(Hons), MRCP(UK), FHKAM(Med), has disclosed the followingrelevant financial relationships: served as a speaker or a member of a speakers bureau for Pfizer. Ivan F.N. Hung,MD, has disclosed the following relevant financial relationships: served as an advisor or consultant for Pfizer (AsiaPacific Capital Advisory Board), MSD; received conference sponsorships from AstraZeneca, Ferring. Patrick C.Y.Woo, MD, has disclosed the following relevant financial relationships: involved in Tigecycline Evaluation SurveillanceTrial with Pfizer.Author affiliation: The University of Hong Kong, Hong Kong, ChinaDOI: http://dx.doi.org/10.3201/eid2107.150138Emerging Infectious Diseases • www.cdc.gov/eid • Vol. 21, No. 7, July 2015 1101
Page 3 and 4: July 2015SynopsisOn the CoverMarian
Page 5: 1240 Gastroenteritis OutbreaksCause
Page 9 and 10: Disseminated Infections with Talaro
Page 11 and 12: Disseminated Infections with Talaro
Page 13 and 14: Macacine Herpesvirus 1 inLong-Taile
Page 15 and 16: Macacine Herpesvirus 1 in Macaques,
Page 17 and 18: Macacine Herpesvirus 1 in Macaques,
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Page 23: Malaria among Young Infants, Africa
Page 26 and 27: RESEARCHFigure 3. Dynamics of 19-kD
Page 28 and 29: Transdermal Diagnosis of MalariaUsi
Page 30 and 31: RESEARCHFigure 2. A) Acoustic trace
Page 32 and 33: RESEARCHof malaria-infected mosquit
Page 34 and 35: Lack of Transmission amongClose Con
Page 36 and 37: RESEARCH(IFA) and microneutralizati
Page 38 and 39: RESEARCHoropharyngeal, and serum sa
Page 40 and 41: RESEARCH6. Assiri A, McGeer A, Perl
Page 42 and 43: RESEARCHadvanced genomic sequencing
Page 44 and 45: RESEARCHTable 2. Next-generation se
Page 46 and 47: RESEARCHTable 3. Mutation analysis
Page 48 and 49: RESEARCHReferences1. Baize S, Panne
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Page 54 and 55: RESEARCHTable 2. HPeV testing of sp
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RESEARCHFigure 5. Distribution of h
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RESEARCHReferences1. Selvarangan R,
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RESEARCHthe left lobe was sampled b
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RESEARCHTable 2. Middle East respir
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RESEARCHseroprevalence in domestic
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RESEARCHmeasure their current surve
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RESEARCHTable 2. States with labora
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RESEARCHFigure 2. Comparison of sur
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RESEARCH9. Centers for Disease Cont
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RESEARCHthe analyses. Cases in pers
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RESEARCHTable 3. Sampling results (
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RESEARCHpresence of Legionella spp.
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Seroprevalence for Hepatitis Eand O
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RESEARCHTable 1. Description of stu
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RESEARCHTable 3. Crude and adjusted
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RESEARCHrates by gender or HIV stat
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RESEARCH25. Taha TE, Kumwenda N, Ka
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POLICY REVIEWDutch Consensus Guidel
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POLICY REVIEWTable 3. Comparison of
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POLICY REVIEW6. Botelho-Nevers E, F
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DISPATCHESFigure 1. Phylogenetic tr
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DISPATCHESSevere Pediatric Adenovir
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DISPATCHESTable 1. Demographics and
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DISPATCHES13. Kim YJ, Hong JY, Lee
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DISPATCHESTable. Alignment of resid
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DISPATCHESFigure 2. Interaction of
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DISPATCHESSchmallenberg Virus Recur
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DISPATCHESFigure 2. Detection of Sc
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DISPATCHESFigure 1. Histopathologic
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DISPATCHESFigure 2. Detection of fo
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Influenza Virus Strains in the Amer
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Novel Arenavirus Isolates from Nama
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Novel Arenaviruses, Southern Africa
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Readability of Ebola Informationon
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Readability of Ebola Information on
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Patients under investigation for ME
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Patients under investigation for ME
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Wildlife Reservoir for Hepatitis E
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Asymptomatic Malaria and Other Infe
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Asymptomatic Malaria in Children fr
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Bufavirus in Wild Shrews and Nonhum
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Bufavirus in Wild Shrews and Nonhum
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Range Expansion for Rat Lungworm in
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Slow Clearance of Plasmodium falcip
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Slow Clearance of Plasmodium falcip
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Gastroenteritis Caused by Norovirus
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Ebola Virus Stability on Surfaces a
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Ebola Virus Stability on Surfaces a
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Outbreak of Ciprofloxacin-Resistant
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Outbreak of S. sonnei, South KoreaT
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Rapidly Expanding Range of Highly P
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Cluster of Ebola Virus Disease, Bon
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Cluster of Ebola Virus Disease, Lib
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ANOTHER DIMENSIONThe Past Is Never
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Measles Epidemic, Boston, Massachus
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LETTERSInfluenza A(H5N6)Virus Reass
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LETTERSsystem (8 kb-span paired-end
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LETTERS3. Van Hong N, Amambua-Ngwa
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LETTERSTable. Prevalence of Bartone
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LETTERSavian influenza A(H5N1) viru
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LETTERSprovinces and a total of 200
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LETTERS7. Manian FA. Bloodstream in
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LETTERSforward projections. N Engl
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LETTERS3. Guindon S, Gascuel OA. Si
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BOOKS AND MEDIAin the port cities o
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ABOUT THE COVERNorth was not intere
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Earning CME CreditTo obtain credit,
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Emerging Infectious Diseases is a p
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