Earning CME CreditTo obtain credit, you should first read the journal article. After reading the article, you should be able to answer the following,related, multiple-choice questions. To complete the questions (with a minimum 75% passing score) and earn continuing medicaleducation (CME) credit, please go to http://www.medscape.org/journal/eid. Credit cannot be obtained for tests completedon paper, although you may use the worksheet below to keep a record of your answers. You must be a registered user onMedscape.org. If you are not registered on Medscape.org, please click on the “Register” link on the right hand side of thewebsite to register. Only one answer is correct for each question. Once you successfully answer all post-test questions you willbe able to view and/or print your certificate. For questions regarding the content of this activity, contact the accredited provider,CME@medscape.net. For technical assistance, contact CME@webmd.net. American Medical Association’s Physician’s RecognitionAward (AMA PRA) credits are accepted in the US as evidence of participation in CME activities. For further informationon this award, please refer to http://www.ama-assn.org/ama/pub/about-ama/awards/ama-physicians-recognition-award.page.The AMA has determined that physicians not licensed in the US who participate in this CME activity are eligible for AMA PRACategory 1 Credits. Through agreements that the AMA has made with agencies in some countries, AMA PRA credit maybe acceptable as evidence of participation in CME activities. If you are not licensed in the US, please complete the questionsonline, print the certificate and present it to your national medical association for review.Article TitleParechovirus Genotype 3 Outbreak among Infants,New South Wales, Australia, 2013–2014CME Questions1. Your patient is an 18-month-old Australian boypresenting with fever and presumed sepsis. Accordingto the surveillance report by Cumming and colleagues,which of the following statements about the clinicaland epidemiologic features of a human parechovirusgenotype 3 (HPeV3) outbreak among Australian infantsis correct?A. Between October 2013 and February 2014, a total of183 cases of HPeV3 were identified in NSW infantsB. Three-quarters of affected infants were girlsC. Half of affected infants required hospitalizationD. Common symptoms were diarrhea, sleepiness, andcough2. According to the surveillance report by Cummingand colleagues, which of the following statementsabout the presentation of the HPeV3 outbreakin Australia compared with that in the northernhemisphere is correct?A. The Australian outbreak affected slightly younger infantsB. The Australian outbreak had a more evengender splitC. Frequency of skin rash was lower in the AustralianoutbreakD. Peak number of cases was later than documented inthe northern hemisphere3. According to the surveillance report by Cummingand colleagues, which of the following statementsabout the efficacy of active surveillance in detectingand monitoring the HPeV3 outbreak among Australianinfants would most likely be accurate?A. Syndromic surveillance was not useful for outbreakmonitoringB. Public health response had no apparent effect oninfant length of stayC. Awareness-raising communication strategies wereineffectiveD. Active surveillance is resource intensive but helpedto define the infection and link it with a syndromicsurveillance indicatorActivity Evaluation1. The activity supported the learning objectives.Strongly DisagreeStrongly Agree1 2 3 4 52. The material was organized clearly for learning to occur.Strongly DisagreeStrongly Agree1 2 3 4 53. The content learned from this activity will impact my practice.Strongly DisagreeStrongly Agree1 2 3 4 54. The activity was presented objectively and free of commercial bias.Strongly DisagreeStrongly Agree1 2 3 4 51284 Emerging Infectious Diseases • www.cdc.gov/eid • Vol. 21, No. 7, July 2015
Emerging Infectious Diseases is a peer-reviewed journal established expressly to promote the recognition of new andreemerging infectious diseases around the world and improve the understanding of factors involved in disease emergence, prevention, and elimination.The journal is intended for professionals in infectious diseases and related sciences. We welcome contributions from infectious disease specialists inacademia, industry, clinical practice, and public health, as well as from specialists in economics, social sciences, and other disciplines. Manuscripts in allcategories should explain the contents in public health terms. For information on manuscript categories and suitability of proposed articles, see below andvisit http://wwwnc.cdc.gov/eid/pages/author-resource-center.htm.Summary of Authors’ InstructionsAuthor’s Instructions. For a complete list of EID’s manuscript guidelines, see theauthor resource page: http://wwwnc.cdc.gov/eid/page/author-resource-center.Manuscript Submission. To submit a manuscript, access Manuscript Central fromthe Emerging Infectious Diseases web page (www.cdc.gov/eid). Include a cover letterindicating the proposed category of the article (e.g., Research, Dispatch), verifying theword and reference counts, and confirming that the final manuscript has been seen andapproved by all authors. Complete provided Authors Checklist.Manuscript Preparation. For word processing, use MS Word. Set the documentto show continuous line numbers. List the following information in this order: title page,article summary line, keywords, abstract, text, acknowledgments, biographical sketch,references, tables, and figure legends. Appendix materials and figures should be inseparate files.Title Page. Give complete information about each author (i.e., full name, graduatedegree(s), affiliation, and the name of the institution in which the work was done). Clearlyidentify the corresponding author and provide that author’s mailing address (includephone number, fax number, and email address). Include separate word counts for abstractand text.Keywords. Use terms as listed in the National Library of Medicine MedicalSubject Headings index (www.ncbi.nlm.nih.gov/mesh).Text. Double-space everything, including the title page, abstract, references, tables,and figure legends. Indent paragraphs; leave no extra space between paragraphs. Aftera period, leave only one space before beginning the next sentence. Use 12-point TimesNew Roman font and format with ragged right margins (left align). Italicize (rather thanunderline) scientific names when needed.Biographical Sketch. Include a short biographical sketch of the first author—bothauthors if only two. Include affiliations and the author’s primary research interests.References. Follow Uniform Requirements (www.icmje.org/index.html). Do notuse endnotes for references. Place reference numbers in parentheses, not superscripts.Number citations in order of appearance (including in text, figures, and tables).Cite personal communications, unpublished data, and manuscripts in preparation orsubmitted for publication in parentheses in text. Consult List of Journals Indexed inIndex Medicus for accepted journal abbreviations; if a journal is not listed, spell outthe journal title. List the first six authors followed by “et al.” Do not cite references inthe abstract.Tables. Provide tables within the manuscript file, not as separate files. Use the MSWord table tool, no columns, tabs, spaces, or other programs. Footnote any use of boldface.Tables should be no wider than 17 cm. Condense or divide larger tables. Extensivetables may be made available online only.Figures. Submit editable figures as separate files (e.g., Microsoft Excel, PowerPoint).Photographs should be submitted as high-resolution (600 dpi) .tif or .jpeg files. Do notembed figures in the manuscript file. Use Arial 10 pt. or 12 pt. font for lettering so thatfigures, symbols, lettering, and numbering can remain legible when reduced to print size.Place figure keys within the figure. Figure legends should be placed at the end of themanuscript file.Videos. Submit as AVI, MOV, MPG, MPEG, or WMV. Videos should not exceed 5minutes and should include an audio description and complete captioning. If audio isnot available, provide a description of the action in the video as a separate Word file.Published or copyrighted material (e.g., music) is discouraged and must be accompaniedby written release. If video is part of a manuscript, files must be uploaded with manuscriptsubmission. When uploading, choose “Video” file. Include a brief video legend inthe manuscript file.Types of ArticlesPerspectives. Articles should not exceed 3,500 words and 40 references. Use of subheadingsin the main body of the text is recommended. Photographs and illustrations areencouraged. Provide a short abstract (150 words), 1-sentence summary, and biographicalsketch. Articles should provide insightful analysis and commentary about new and reemerginginfectious diseases and related issues. Perspectives may address factors known toinfluence the emergence of diseases, including microbial adaptation and change, humandemographics and behavior, technology and industry, economic development and land use,international travel and commerce, and the breakdown of public health measures.Synopses. Articles should not exceed 3,500 words and 40 references. Use of subheadingsin the main body of the text is recommended. Photographs and illustrations areencouraged. Provide a short abstract (150 words), 1-sentence summary, and biographicalsketch. This section comprises concise reviews of infectious diseases or closely relatedtopics. Preference is given to reviews of new and emerging diseases; however, timelyupdates of other diseases or topics are also welcome.Research. Articles should not exceed 3,500 words and 40 references. Use of subheadingsin the main body of the text is recommended. Photographs and illustrations areencouraged. Provide a short abstract (150 words), 1-sentence summary, and biographicalsketch. Report laboratory and epidemiologic results within a public health perspective.Explain the value of the research in public health terms and place the findings in a largerperspective (i.e., “Here is what we found, and here is what the findings mean”).Policy and Historical Reviews. Articles should not exceed 3,500 words and 40 references.Use of subheadings in the main body of the text is recommended. Photographsand illustrations are encouraged. Provide a short abstract (150 words), 1-sentence summary,and biographical sketch. Articles in this section include public health policy or historicalreports that are based on research and analysis of emerging disease issues.Dispatches. Articles should be no more than 1,200 words and need not be dividedinto sections. If subheadings are used, they should be general, e.g., “The Study” and“Conclusions.” Provide a brief abstract (50 words); references (not to exceed 15); figuresor illustrations (not to exceed 2); tables (not to exceed 2); and biographical sketch. Dispatchesare updates on infectious disease trends and research that include descriptionsof new methods for detecting, characterizing, or subtyping new or reemerging pathogens.Developments in antimicrobial drugs, vaccines, or infectious disease prevention or eliminationprograms are appropriate. Case reports are also welcome.Another Dimension. Thoughtful essays, short stories, or poems on philosophical issuesrelated to science, medical practice, and human health. Topics may include scienceand the human condition, the unanticipated side of epidemic investigations, or how peopleperceive and cope with infection and illness. This section is intended to evoke compassionfor human suffering and to expand the science reader’s literary scope. Manuscripts areselected for publication as much for their content (the experiences they describe) as fortheir literary merit. Include biographical sketch.Letters. Letters commenting on recent articles as well as letters reporting cases, outbreaks,or original research, are welcome. Letters commenting on articles should containno more than 300 words and 5 references; they are more likely to be published if submittedwithin 4 weeks of the original article’s publication. Letters reporting cases, outbreaks,or original research should contain no more than 800 words and 10 references. They mayhave 1 figure or table and should not be divided into sections. No biographical sketchis needed.Commentaries. Thoughtful discussions (500–1,000 words) of current topics.Commentaries may contain references (not to exceed 15) but no abstract, figures, ortables. Include biographical sketch.Books, Other Media. Reviews (250–500 words) of new books or other media onemerging disease issues are welcome. Title, author(s), publisher, number of pages, andother pertinent details should be included.Conference Summaries. Summaries of emerging infectious disease conference activities(500–1,000 words) are published online only. They should be submitted no laterthan 6 months after the conference and focus on content rather than process. Provideillustrations, references, and links to full reports of conference activities.Online Reports. Reports on consensus group meetings, workshops, and other activitiesin which suggestions for diagnostic, treatment, or reporting methods related toinfectious disease topics are formulated may be published online only. These should notexceed 3,500 words and should be authored by the group. We do not publish officialguidelines or policy recommendations.Photo Quiz. The photo quiz (1,200 words) highlights a person who made notablecontributions to public health and medicine. Provide a photo of the subject, a brief clueto the person’s identity, and five possible answers, followed by an essay describing theperson’s life and his or her significance to public health, science, and infectious disease.Etymologia. Etymologia (100 words, 5 references). We welcome thoroughly researchedderivations of emerging disease terms. Historical and other context could beincluded.Announcements. We welcome brief announcements of timely events of interest toour readers. Announcements may be posted online only, depending on the event date.Email to eideditor@cdc.gov.
- Page 3 and 4:
July 2015SynopsisOn the CoverMarian
- Page 5 and 6:
1240 Gastroenteritis OutbreaksCause
- Page 7 and 8:
SYNOPSISDisseminated Infections wit
- Page 9 and 10:
Disseminated Infections with Talaro
- Page 11 and 12:
Disseminated Infections with Talaro
- Page 13 and 14:
Macacine Herpesvirus 1 inLong-Taile
- Page 15 and 16:
Macacine Herpesvirus 1 in Macaques,
- Page 17 and 18:
Macacine Herpesvirus 1 in Macaques,
- Page 19:
Macacine Herpesvirus 1 in Macaques,
- Page 23:
Malaria among Young Infants, Africa
- Page 26 and 27:
RESEARCHFigure 3. Dynamics of 19-kD
- Page 28 and 29:
Transdermal Diagnosis of MalariaUsi
- Page 30 and 31:
RESEARCHFigure 2. A) Acoustic trace
- Page 32 and 33:
RESEARCHof malaria-infected mosquit
- Page 34 and 35:
Lack of Transmission amongClose Con
- Page 36 and 37:
RESEARCH(IFA) and microneutralizati
- Page 38 and 39:
RESEARCHoropharyngeal, and serum sa
- Page 40 and 41:
RESEARCH6. Assiri A, McGeer A, Perl
- Page 42 and 43:
RESEARCHadvanced genomic sequencing
- Page 44 and 45:
RESEARCHTable 2. Next-generation se
- Page 46 and 47:
RESEARCHTable 3. Mutation analysis
- Page 48 and 49:
RESEARCHReferences1. Baize S, Panne
- Page 50 and 51:
Parechovirus Genotype 3 Outbreakamo
- Page 52 and 53:
RESEARCHFigure 1. Venn diagramshowi
- Page 54 and 55:
RESEARCHTable 2. HPeV testing of sp
- Page 56 and 57:
RESEARCHFigure 5. Distribution of h
- Page 58 and 59:
RESEARCHReferences1. Selvarangan R,
- Page 60 and 61:
RESEARCHthe left lobe was sampled b
- Page 62 and 63:
RESEARCHTable 2. Middle East respir
- Page 64 and 65:
RESEARCHseroprevalence in domestic
- Page 66 and 67:
RESEARCHmeasure their current surve
- Page 68 and 69:
RESEARCHTable 2. States with labora
- Page 70 and 71:
RESEARCHFigure 2. Comparison of sur
- Page 72 and 73:
RESEARCH9. Centers for Disease Cont
- Page 74 and 75:
RESEARCHthe analyses. Cases in pers
- Page 76 and 77:
RESEARCHTable 3. Sampling results (
- Page 78 and 79:
RESEARCHpresence of Legionella spp.
- Page 80 and 81:
Seroprevalence for Hepatitis Eand O
- Page 82 and 83:
RESEARCHTable 1. Description of stu
- Page 84 and 85:
RESEARCHTable 3. Crude and adjusted
- Page 86 and 87:
RESEARCHrates by gender or HIV stat
- Page 88 and 89:
RESEARCH25. Taha TE, Kumwenda N, Ka
- Page 90 and 91:
POLICY REVIEWDutch Consensus Guidel
- Page 92 and 93:
POLICY REVIEWTable 3. Comparison of
- Page 94 and 95:
POLICY REVIEW6. Botelho-Nevers E, F
- Page 96 and 97:
DISPATCHESFigure 1. Phylogenetic tr
- Page 98 and 99:
DISPATCHESSevere Pediatric Adenovir
- Page 100 and 101:
DISPATCHESTable 1. Demographics and
- Page 102 and 103:
DISPATCHES13. Kim YJ, Hong JY, Lee
- Page 104 and 105:
DISPATCHESTable. Alignment of resid
- Page 106 and 107:
DISPATCHESFigure 2. Interaction of
- Page 108 and 109:
DISPATCHESSchmallenberg Virus Recur
- Page 110 and 111:
DISPATCHESFigure 2. Detection of Sc
- Page 112 and 113:
DISPATCHESFigure 1. Histopathologic
- Page 114:
DISPATCHESFigure 2. Detection of fo
- Page 117 and 118:
Influenza Virus Strains in the Amer
- Page 119 and 120:
Novel Arenavirus Isolates from Nama
- Page 121 and 122:
Novel Arenaviruses, Southern Africa
- Page 123 and 124:
Readability of Ebola Informationon
- Page 125 and 126:
Readability of Ebola Information on
- Page 127 and 128:
Patients under investigation for ME
- Page 129 and 130:
Patients under investigation for ME
- Page 131 and 132:
Wildlife Reservoir for Hepatitis E
- Page 133 and 134:
Asymptomatic Malaria and Other Infe
- Page 135 and 136:
Asymptomatic Malaria in Children fr
- Page 137 and 138:
Bufavirus in Wild Shrews and Nonhum
- Page 139 and 140: Bufavirus in Wild Shrews and Nonhum
- Page 141 and 142: Range Expansion for Rat Lungworm in
- Page 143 and 144: Slow Clearance of Plasmodium falcip
- Page 145 and 146: Slow Clearance of Plasmodium falcip
- Page 147 and 148: Gastroenteritis Caused by Norovirus
- Page 149 and 150: Ebola Virus Stability on Surfaces a
- Page 151 and 152: Ebola Virus Stability on Surfaces a
- Page 153 and 154: Outbreak of Ciprofloxacin-Resistant
- Page 155 and 156: Outbreak of S. sonnei, South KoreaT
- Page 157 and 158: Rapidly Expanding Range of Highly P
- Page 159 and 160: Cluster of Ebola Virus Disease, Bon
- Page 161 and 162: Cluster of Ebola Virus Disease, Lib
- Page 163 and 164: ANOTHER DIMENSIONThe Past Is Never
- Page 165 and 166: Measles Epidemic, Boston, Massachus
- Page 167 and 168: LETTERSInfluenza A(H5N6)Virus Reass
- Page 169 and 170: LETTERSsystem (8 kb-span paired-end
- Page 171 and 172: LETTERS3. Van Hong N, Amambua-Ngwa
- Page 173 and 174: LETTERSTable. Prevalence of Bartone
- Page 175 and 176: LETTERSavian influenza A(H5N1) viru
- Page 177 and 178: LETTERSprovinces and a total of 200
- Page 179 and 180: LETTERS7. Manian FA. Bloodstream in
- Page 181 and 182: LETTERSforward projections. N Engl
- Page 183 and 184: LETTERS3. Guindon S, Gascuel OA. Si
- Page 185 and 186: BOOKS AND MEDIAin the port cities o
- Page 187 and 188: ABOUT THE COVERNorth was not intere
- Page 189: Earning CME CreditTo obtain credit,