_____________________________________________________________________________________Béchet, M. <strong>and</strong> Blondeau, R. (1998). Iron deficiency-<strong>in</strong>duced tetracycl<strong>in</strong>e production <strong>in</strong>submerged cultures by Streptomyces aure<strong>of</strong>aciens. J. Appl. Microbiol. 84:889-894.Bechthold, A., Sohng, J.K., Smith, T.M., Chu, X. <strong>and</strong> Floss, H.G. (1995). Identification<strong>of</strong> Streptomyces violaceoruber Tü22 genes <strong>in</strong>volved <strong>in</strong> the biosynthesis <strong>of</strong> granatic<strong>in</strong>.Mol. Gen. Genet. 248:610-620.Benslimane, C., Lebrihi, A., Lounès, A., Lefebvre, G <strong>and</strong> Germa<strong>in</strong>, P. (1995). Influence<strong>of</strong> dextr<strong>in</strong>s on the assimilation <strong>of</strong> yeast extract am<strong>in</strong>o acids <strong>in</strong> culture <strong>of</strong> Streptomycesamb<strong>of</strong>aciens producer <strong>of</strong> spiramyc<strong>in</strong>. Enzyme. Microb. Technol. 17:1003-1013.Bèrdy, J. “The discovery <strong>of</strong> new bioactive microbial metabolites: screen<strong>in</strong>g <strong>and</strong>identification.” Bioactive metabolites from microorganisms. Progress <strong>in</strong> IndustrialMicrobiology. Volume 27. Ed. Bushell, M.E <strong>and</strong> Gräfe, U. Amsterdam, TheNetherl<strong>and</strong>s. Elsevier Science Publishers B.V, 1989. 3-25.Bèrdy, J. “Are act<strong>in</strong>omycetes exhausted as a source <strong>of</strong> secondary metabolites?” Thebiology <strong>of</strong> the act<strong>in</strong>omycetes ’94: proceed<strong>in</strong>g <strong>of</strong> the n<strong>in</strong>th <strong>in</strong>ternational symposium on thebiology <strong>of</strong> the act<strong>in</strong>omycetes. Ed. Debabov, V.G., Dudnik, Y.V <strong>and</strong> Danilenko, V.N.Moscow, Russia.1995, 13-24.Bergh, S <strong>and</strong> Uhlen, M. (1992). Analysis <strong>of</strong> a polyketide synthesis-encod<strong>in</strong>g gene cluster<strong>of</strong> Streptomyces curacoi. Gene 117:131-136.Bhattacharyya, B.K., Pal, S.C. <strong>and</strong> Sen, S.K. (1998). Antibiotic production byStreptomyces hygroscopicus D1.5: cultural effect. Rev. Microbiol. 29(3):1-5.Bibb, M.J., Biro, S., Motamedi, H., Coll<strong>in</strong>s, J.F <strong>and</strong> Hutch<strong>in</strong>son, R.C. (1989). Analysis <strong>of</strong>the nucleotide sequence <strong>of</strong> the Streptomyces glaucescens tcmI genes provides key<strong>in</strong>formation about the enzymology <strong>of</strong> polyketide antibiotic biosynthesis. EMBO J. 8(9):2727-2736.Bibb, M.J, Sherman, D.H, Omura, S <strong>and</strong> Hopwood, D.A. (1994). Clon<strong>in</strong>g, sequenc<strong>in</strong>g<strong>and</strong> deduced functions <strong>of</strong> a cluster <strong>of</strong> Streptomyces genes probably encod<strong>in</strong>g biosynthesis<strong>of</strong> the polyketide antibiotic frenolic<strong>in</strong>. Gene 142:31-39.B<strong>in</strong>nie, C., Cossar, J.D <strong>and</strong> Stewart, D.I.H. (1997). Heterologous biopharmaceuticalprote<strong>in</strong> expression <strong>in</strong> Streptomyces. Trends Biotechnol. 15:315-319.Biot, A.M. “Virg<strong>in</strong>iamyc<strong>in</strong>: Properties, biosynthesis, <strong>and</strong> fermentation.” Biotechnology<strong>of</strong> <strong>in</strong>dustrial antibiotics, 1 st ed. Ed. V<strong>and</strong>amme EJ. New York <strong>and</strong> Basel: Marcel Dekker,1984. 695-720.Biró, S., Békési, I., Vitális, S. <strong>and</strong> Szabó, G. (1980). A substance effect<strong>in</strong>g differentiation<strong>in</strong> Streptomyces griseus. Purification <strong>and</strong> properties. Eur. J. Biochem. 103(2):359-363.____________________________________________________________________________________137
_____________________________________________________________________________________Boucher, Y. <strong>and</strong> Doolittle, W.F. (2000). The role <strong>of</strong> lateral gene transfer <strong>in</strong> the evolution <strong>of</strong>isoprenoid biosynthesis pathways. Mol. Microbiol. 37(4):703-716.Brakhage, A.A. (1998). Molecular regulation <strong>of</strong> β-Lactam biosynthesis <strong>in</strong> filamentousfungi. Microbiol. Mol. Biol. Rev. 62(3):547-585.Brana, A. F. & Dema<strong>in</strong>, A. L. “Nitrogen control <strong>of</strong> antibiotic biosynthesis <strong>in</strong>act<strong>in</strong>omycetes.” Nitrogen Source Control <strong>of</strong> Microbial Processes Ed. Sanchez-Esquivel.Boca Raton, FL: CRC Press, 1988. 99-119.Br<strong>and</strong>ão, P.F.B., Torimura, M., Kurane, R. <strong>and</strong> Bull, A.T. (2002). Dreplication forbiotechnology screen<strong>in</strong>g: PyMS analysis <strong>and</strong> PCR-RFLP-SSCP (PKS) pr<strong>of</strong>il<strong>in</strong>g <strong>of</strong> 16SrRNA genes <strong>of</strong> mar<strong>in</strong>e <strong>and</strong> terrestrial act<strong>in</strong>omycetes. Appl. Microbiol. Biotechnol. 58:77-83.Braun, S <strong>and</strong> Vecht-Lifshitz, S.E. (1991). Mycelial morphology <strong>and</strong> metaboliteproduction. Trends Biotechnol. 9:63-68.Brautaset, T., Sekurova, O.N., Sletta, H., Ell<strong>in</strong>gsen, T.E., Strøm, A.R., Valla, S. <strong>and</strong>Zotchev, S.B. (2000). Biosynthesis <strong>of</strong> the polyene antifungal antibiotic nystat<strong>in</strong> <strong>in</strong>Streptomyces noursei ATCC 11455: analysis <strong>of</strong> the gene cluster <strong>and</strong> deduction <strong>of</strong> thebiosynthetic pathway. Chem. Biol. 7:395-403.Brown, M.S., Dirlam, J.P., McArthur, H.A.I., McCormick, E.L., Morse, B.K., Murphy,P.A., O’ Connell, T.N., Pacey, M., Rescek, D.M., Ruddock, J. <strong>and</strong> Wax, R.G. (1999).Production <strong>of</strong> 6-deoxy-13-cyclopropyl-erythromyc<strong>in</strong> B by Saccharopolyspora erythreaNRRL 18643. J. Antibiot. 52(8):742-747.Brünker, P., McK<strong>in</strong>ney, K., Sterner, O., M<strong>in</strong>as, W. <strong>and</strong> Bailey, J.E. (1999). Isolation <strong>and</strong>characterization <strong>of</strong> the naphthocycl<strong>in</strong>one gene cluster from Streptomyces arenae DSM40737 <strong>and</strong> heterologous expression <strong>of</strong> the polyketide synthase genes. Gene 227:125-135.Büchs, J. (2001). Introduction to advantages <strong>and</strong> problems <strong>of</strong> shaken cultures. Biochem.Eng. J. 7:91-98.Bull, A.T., Huck, T.A., Bushell, M.E. “Optimisation strategies <strong>in</strong> microbial processdevelopment <strong>and</strong> optimisation” Microbial growth dynamics. Ed. Poole, R.K., Baz<strong>in</strong>, M.J<strong>and</strong> Keevil, C.W. Oxford, UK: IRL Press, 1990. 145-168.Bull, A.T., Ward, A.C. <strong>and</strong> Goodfellow, M. (2000). Search <strong>and</strong> discovery strategies forbiotechnology: the paradigm shift. Microbiol. Mol. Biol. Rev. 64(3):573-606.Bu’Lock, J.D., Nisbet, L.J <strong>and</strong> W<strong>in</strong>stanley, D.J. (1982). Bioactive microbial products:search <strong>and</strong> discovery. Society for general microbiology. Academic Press Inc. London,U.K.____________________________________________________________________________________138
- Page 1 and 2:
___________________________________
- Page 3 and 4:
___________________________________
- Page 5 and 6:
___________________________________
- Page 7 and 8:
___________________________________
- Page 9 and 10:
___________________________________
- Page 11 and 12:
___________________________________
- Page 13 and 14:
___________________________________
- Page 15 and 16:
___________________________________
- Page 17 and 18:
___________________________________
- Page 19 and 20:
BERVANAKIS, G.Chapter 1: INTRODUCTI
- Page 21 and 22:
BERVANAKIS, G.Chapter 1: INTRODUCTI
- Page 23 and 24:
BERVANAKIS, G.Chapter 1: INTRODUCTI
- Page 25 and 26:
BERVANAKIS, G.Chapter 1: INTRODUCTI
- Page 27 and 28:
BERVANAKIS, G.Chapter 1: INTRODUCTI
- Page 29 and 30:
BERVANAKIS, G.Chapter 1: INTRODUCTI
- Page 31 and 32:
BERVANAKIS, G.Chapter 1: INTRODUCTI
- Page 33 and 34:
BERVANAKIS, G.Chapter 1: INTRODUCTI
- Page 35 and 36:
BERVANAKIS, G.Chapter 1: INTRODUCTI
- Page 37 and 38:
BERVANAKIS, G.Chapter 1: INTRODUCTI
- Page 39 and 40:
BERVANAKIS, G.Chapter 1: INTRODUCTI
- Page 41 and 42:
BERVANAKIS, G.Chapter 1: INTRODUCTI
- Page 43 and 44:
BERVANAKIS, G.Chapter 1: INTRODUCTI
- Page 45 and 46:
BERVANAKIS, G.Chapter 1: INTRODUCTI
- Page 47 and 48:
BERVANAKIS, G.Chapter 1: INTRODUCTI
- Page 49 and 50:
BERVANAKIS, G.Chapter 1: INTRODUCTI
- Page 51 and 52:
BERVANAKIS, G.Chapter 1: INTRODUCTI
- Page 53 and 54:
BERVANAKIS, G.Chapter 1: INTRODUCTI
- Page 55 and 56:
BERVANAKIS, G.Chapter 1: INTRODUCTI
- Page 57 and 58:
BERVANAKIS, G.Chapter 1: INTRODUCTI
- Page 59 and 60:
BERVANAKIS, G.Chapter 1: INTRODUCTI
- Page 61 and 62:
BERVANAKIS, G.Chapter 1: INTRODUCTI
- Page 63 and 64:
BERVANAKIS, G.Chapter 1: INTRODUCTI
- Page 65 and 66:
BERVANAKIS, G.Chapter 1: INTRODUCTI
- Page 67 and 68:
BERVANAKIS, G.Chapter 1: INTRODUCTI
- Page 69 and 70:
BERVANAKIS, G.Chapter 1: INTRODUCTI
- Page 71 and 72:
BERVANAKIS, G.Chapter 2: MATERIALS
- Page 73 and 74:
BERVANAKIS, G.Chapter 2: MATERIALS
- Page 75 and 76:
BERVANAKIS, G.Chapter 2: MATERIALS
- Page 77 and 78:
BERVANAKIS, G.Chapter 2: MATERIALS
- Page 79 and 80:
BERVANAKIS, G.Chapter 2: MATERIALS
- Page 81 and 82:
BERVANAKIS, G.Chapter 2: MATERIALS
- Page 83 and 84:
BERVANAKIS, G.Chapter 2: MATERIALS
- Page 85 and 86:
BERVANAKIS, G.Chapter 2: MATERIALS
- Page 87 and 88:
BERVANAKIS, G.Chapter 2: MATERIALS
- Page 89 and 90:
BERVANAKIS, G.Chapter 2: MATERIALS
- Page 91 and 92:
BERVANAKIS, G.Chapter 3: RESULTSSec
- Page 93 and 94:
BERVANAKIS, G.Chapter 3: RESULTSseq
- Page 95 and 96:
BERVANAKIS, G.Chapter 3: RESULTSFig
- Page 97 and 98:
BERVANAKIS, G._____________________
- Page 99 and 100:
BERVANAKIS, G.Chapter 3: RESULTSwit
- Page 101 and 102:
BERVANAKIS, G.Chapter 3: RESULTSTab
- Page 103 and 104:
BERVANAKIS, G.Chapter 3: RESULTS3.1
- Page 105 and 106:
BERVANAKIS, G.Chapter 3: RESULTSof
- Page 107 and 108: BERVANAKIS, G. Chapter 3: RESULTS18
- Page 109 and 110: BERVANAKIS, G.Chapter 3: RESULTS3.1
- Page 111 and 112: BERVANAKIS, G.Chapter 3: RESULTSDes
- Page 113 and 114: BERVANAKIS, G.Chapter 3: RESULTS3.1
- Page 115 and 116: BERVANAKIS, G.Chapter 3: RESULTSTab
- Page 117 and 118: BERVANAKIS, G.Chapter 3: RESULTSTab
- Page 119 and 120: BERVANAKIS, G.Chapter 3: RESULTSOf
- Page 121 and 122: BERVANAKIS, G.Chapter 3: RESULTSTab
- Page 123 and 124: BERVANAKIS, G.Chapter 3: RESULTS3.2
- Page 125 and 126: BERVANAKIS, G.Chapter 3: RESULTSLan
- Page 127 and 128: BERVANAKIS, G.Chapter 3: RESULTSTab
- Page 129 and 130: BERVANAKIS, G.Chapter 3: RESULTSThe
- Page 131 and 132: BERVANAKIS, G.Chapter 3: RESULTS3.2
- Page 133 and 134: BERVANAKIS, G.Chapter 4: DISCUSSION
- Page 135 and 136: BERVANAKIS, G.Chapter 4: DISCUSSION
- Page 137 and 138: BERVANAKIS, G.Chapter 4: DISCUSSION
- Page 139 and 140: BERVANAKIS, G.Chapter 4: DISCUSSION
- Page 141 and 142: BERVANAKIS, G.Chapter 4: DISCUSSION
- Page 143 and 144: BERVANAKIS, G.Chapter 4: DISCUSSION
- Page 145 and 146: BERVANAKIS, G.Chapter 4: DISCUSSION
- Page 147 and 148: BERVANAKIS, G.Chapter 4: DISCUSSION
- Page 149 and 150: BERVANAKIS, G.Chapter 4: DISCUSSION
- Page 151 and 152: BERVANAKIS, G.Chapter 4: DISCUSSION
- Page 153 and 154: BERVANAKIS, G.Chapter 4: DISCUSSION
- Page 155 and 156: BERVANAKIS, G.Chapter 4: DISCUSSION
- Page 157: ___________________________________
- Page 161 and 162: ___________________________________
- Page 163 and 164: ___________________________________
- Page 165 and 166: ___________________________________
- Page 167 and 168: ___________________________________
- Page 169 and 170: ___________________________________
- Page 171 and 172: ___________________________________
- Page 173 and 174: ___________________________________
- Page 175 and 176: ___________________________________
- Page 177 and 178: ___________________________________
- Page 179 and 180: ___________________________________
- Page 181 and 182: ___________________________________
- Page 183 and 184: ___________________________________
- Page 185 and 186: ___________________________________
- Page 187 and 188: ___________________________________
- Page 189 and 190: ___________________________________
- Page 191 and 192: ___________________________________
- Page 193 and 194: ___________________________________
- Page 195 and 196: ___________________________________
- Page 197 and 198: ___________________________________
- Page 199 and 200: ___________________________________
- Page 201 and 202: ___________________________________
- Page 203 and 204: ___________________________________
- Page 205 and 206: ___________________________________
- Page 207 and 208: ___________________________________
- Page 209:
BERVANAKIS, G. APPENDIX 1Appendix 1