Detection and Expression of Biosynthetic Genes in Actinobacteria ...

_____________________________________________________________________________________Strobel, G.A and Long, D.M. (1998). Endophytic microbes embody pharmaceuticalpotential. ASM News 64(5):263-268.Strohl, W.R. “Industrial Antibiotics: Today and the future.” Biotechnology ofantibiotics. 2nd Ed. Vol. 82. Ed. Strohl, W.R. New York. USA: Marcel Dekker, Inc,1997. 1-43.Stülke, J. and Hillen, W. (1999). Carbon catabolite repression in bacteria. Curr. Opin.Microbiol. 2:195-201.Stutzman-Engwall, K.J., Otten, S.L and Hutchinson, C.R. (1992). Regulation ofsecondary metabolism in Streptomyces spp. and overproduction of daunorubicin inStreptomyces peucetius. J. Bacteriol. 174(1):144-154.Suzuki, K., Nagai, K., Shimizu, Y and Suzuki, Y. (1994). Search for actinomycetes inscreening for new bioactive compounds. Actinomycetol. 8(2):122-127.Swan, D.G, Rodríguez, A.M, Vilches, C, Méndez, C, Salas, J.A. (1994). Characterisationof a Streptomyces antibioticus gene encoding a type I polyketide synthase which has anunusual coding sequence. Mol Gen Genet. 242(3):358-32.Takano, E. and Bibb, M.J. (1994). The stringent response, ppGpp and Antibioticproduction in Streptomyces coelicolor A3(2). Actinomycetol. 8(1):1-16.Takano, E., Gramajo, H.C., Strauch, E., Andres, N., White, J and Bibb, M.J. (1992).Transcriptional regulation of the redD transcritional activator gene accounts for growthphase-dependentproduction of the antibiotic undecylprodigiosin in Streptomycescoelicolor A3(2). Mol. Microbiol. 6(19):2797-2804.Takenaka, S., Yoshida, K., Yamaguchi, O., Shimizu, K., Morohoshi, T and Kinoshita, K.(1998). Enhancement of mycinamicin production by dotriacolide in Micromonosporagriseorubida. FEMS Microbiol. Lett. 167:95-100.Takizawa, M., Colwell, R.R. and Hill, R.T. (1993). Isolation and diversity ofactinomycetes in the chesapeake bay. Appl. Environ. Microbiol. 59(4):997-1002.Tang, L. and McDaniel, R. (2001). Construction of desosamine containing polyketidelibraries using a glycosyltransferase with broad substrate specificity. Chem. Biol.8(6):547-555.Tang, L., Fu, H and McDaniel, R. (2000). Formation of functional heterologouscomplexes using subunits from the picromycin, erythromycin and oleandomycinpolyketide synthases. Chem. Biol. 7:77-84.Thamchaipenet, A., Talawanich, Y., Hunter, I.S and Goodfellow, M. “Identification oftype I polyketide-producing strains in some actinomycetes isolated from the composite____________________________________________________________________________________162