Detection and Expression of Biosynthetic Genes in Actinobacteria ...

_____________________________________________________________________________________Sheldon, P.J., Mao, Y., He, M and Sherman, D.H. (1999). Mitomycin resistance inStreptomyces lavendulae includes a novel drug-binding-protein-dependent export system.J. Bacteriol. 181(8):2507-2512.Sherman,D.H., Malpartida, F., Bibb, M.J., Kieser, H.M., Bibb, M, J. and Hopwood, D.A.(1989). Structure and deduced function of the granaticin-producing polyketide synthasegene cluster of Streptomyces violaceoruber Tü22. EMBO J. 8(9):2717-2725.Sheu, D-S, Wang, Y-T and Lee, C-Y. (2000). Rapid detection of polyhydroxyalkanoateaccumulating bacteria isolated from the environment by colony PCR. Microbiology146:2019-2025.Shiffman, D., Mevarech, M., Jensen, S.E., Cohen, G and Aharonowitz, Y.(1988).Cloning and comparative sequence analysis of the gene coding for Isopenicillin Nsynthase in Streptomyces. Mol. Gen. Genet. 214:562-569.Shinkawa, H.(1996). Transcriptional apparatus and its relatives in Streptomyces.Actinomycetol. 10(2):112-120.Siegal, G., van Duynhoven, J and Baldus, M. (1999). Biomolecular NMR:recentadvances in liquids, solids and screening. Curr. Opin. Chem. Biol. 3:530-536.Silver, L and Bostian, K. (1990). Screening of natural products for antimicrobial agents.Eur. J. Clin. Microbiol. Infect. Dis. 9(7):455-461.Sim T.S and Loke P. (2000). Molecular studies on isopenicillin N synthases.Appl. Microbiol. Biotechnol. 54(1):1-8.Sim, T.S., Yonejima, S., Chee Pang, N., Keng Ing, S., Chan, M and Seki, T. Phylogeneticanalysis of β-lactam antibiotic-producing Streptomyces species. 8 th internationalsymposium on biology of actinomycetes. Beijing, China. Chinese society formicrobiology and chinese pharmaceutical association, 1997. 7P26.Smith, D.J., Burnham, M.K.R., Bull, J.H., Hodgson, J.E., Ward, J.M., Browne, P.,Brown, J., Barton, B., Earl, A.J and Turner, G. (1990). β-Lactam antibiotic biosyntheticgenes have been conserved in clusters in prokaryotes and eukaryotes. EMBO J. 9:741-747.Smokvina, T., Mazodier, P., Boccard, F., Thompson, C.J and Guerineau, M. (1990).Construction of a series of pSAM2-based integrative vectors for use in actinomycetes.Gene 94:53-59.Sosio, M., Bossi, E., Bianchi, A. and Donadio, S. (2000a). Multiple peptide synthetasegene clusters in actinomycetes. Mol. Gen. Genet. 264:213-221.____________________________________________________________________________________160