th  - 1988 - 51st ENC Conference

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Eve 8"50] NMR APPROACHES TO UNDERSTANDING NATURAL AND SYNTHETIC ENZYMES Jeremy K. M. Sanders* Department of Chemistry University Chemical Laboratory Lensfield Road Cambridge CB2 1EW Recent advances in NMR spectroscopy have given us powerful new tools for observing and understanding the details of chemical and biochemical transformations. The problem faced by the chemist or biochemist is how to choose the best spectroscopic s~ategy for solving a particular problem. We must look at each step in the reaction or metabolic process from the point of view of individual nuclei: these are our potential reporters. Once we know how the shift or coupling environment for each potential reporter is likely to change, we can design NMR experiments that select only the spins of interest, even ff the sample is a living organism. These ideas will be illustrated by a wide range of examples including the following: 1. An in vivo deuterium NMR study of formaldehyde dismutases in bacterial cultures. 2. Selective 1H and 13C N]V[R measurements of glutathione biochemistry in bacterial and mammalian cells. 3. One- and two-dimensional IH and 13C studies of iigand binding to 'synthetic enzymes' based on porphyrins. 30
8:30 a.m. 9:00 a.m. 9:10 a.m. 9:20 a.m. 9:50 a.m. 10:20 a.m. TUESDAY MORNING TWO-DIMENSIONAL SPECTROSCOPY C. Wade, Session Chair Patterns and Relaxations. P. Pfandler, U. Eggenberger, D. Limat, S. Wimperis, J. -M. Bohlen, *G. Bodenhausen. Two Dimensional Linear Prediction NMR Spectroscopy. *H. Gesmar, J. J. Led. Multivariate Techniques for Enhancement of Two Dimensional NMR Spectra. H. Grahn, *F. Delaglio, M. W. Roggenbuck, G. C. Levy. 2D Rot=ing Frame Spectroscopy: New Approaches and Prospects. *C. Griesinge~ C. Schonenberge~ R. R. Ernst, R. Bruschweile~ New Twists to Some Old Experiments. *A. Bax, D. Marion, L. Lerner, R. Tschudin. Break. 31
Page 1 and 2: 29 th �� - 1988 Rochester
Page 3 and 4: PROGRAM: This conference program ha
Page 5 and 6: The Executive Committee of the 29th
Page 7 and 8: A A 0 0 ,-..1 I Z Z 0 "c N "1" i 0
Page 9 and 10: Restaurants in Rochester Restaurant
Page 11 and 12: 8:30 a.m. 8:35- 10:05 10:05 - 10:25
Page 13 and 14: 8:30 a.m. 8:35 a.m. 9:05 a.m. 9:15
Page 15 and 16: f~ I UNTRUNCATIO~I OF DIPOLE-DIPOLE
Page 17 and 18: MON 9:25 HIGH RESOLUTION ELECTROPHO
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Page 21 and 22: ~'-O-i 0 N i0:55 MEASUREMENTS OF TW
Page 23 and 24: MON 11:3S 12D CHEMICAL SHIFT ANISOT
Page 25 and 26: 7:30 p.m. 8:00 p.m. 8:10 p.m. 8:40
Page 27 and 28: HON Eve 8:00 The 13C Relaxation Beh
Page 29: THE WORLD AND WONDERS OF 3H NMR SPE
Page 33 and 34: TWO DIMENSIONAL LINEAR PREDICTION N
Page 35 and 36: TUE 9"20 ] 2D ROTATING FRAME SPECTR
Page 37 and 38: 10:40 a.m. 11:00 a.m. 11:20 a.m. 11
Page 39 and 40: TUE ii'00 J WATER SUPPRESSION TECHN
Page 41 and 42: TUE 11:30 J FREQUENCY SWITCHED INVE
Page 43 and 44: 7:30 p.m. 8:00 p.m. 8:30 p.m. 8:50
Page 45 and 46: • . r T[-~-UE ~ t~ve 8:00! 63,65C
Page 47 and 48: TUE Eve 8-50 } Cu NQR OF YBa2Cu30 x
Page 49 and 50: ~X [I'IED 8:30 I REMOVAL OF EXTRANE
Page 51 and 52: . r WED 9:25 ] A STATIC NMR IMAGE O
Page 53 and 54: WED 9" 45 IFLUID AND SOLID STATE NM
Page 55 and 56: i MULTIVOLUME SELECTIVE SPECTROSCOP
Page 57 and 58: [WED 11-10 I SELF SHIELDED GRADIENT
Page 59 and 60: [WED 11:45 ] ANGIOGRAPHY USING MAGN
Page 61 and 62: THU 8:30 "TETHERED" BIOLOGICAL SYST
Page 63 and 64: • / I DYNAMICS OF THE GRAMICIDIN
Page 65 and 66: I THU 9:40 I NMR STUDIES OF ANTI-SP
Page 67 and 68: THU 10"2S I NEW TECHNIQUES POR DYNA
Page 69 and 70: I THU 11 : 05 I DYNAMIC NUCLEAR POL
Page 71 and 72: THIS SECTION CONTAINS A LISTING OF
Page 73 and 74: 9 ELIMINATION OF PHASE ROLL, SOLVEN
Page 75 and 76: 25 NUCLEAR MAGNETIC RESONANCE STUDI
Page 77 and 78: ~k 41 A HYPO-RELAXATION AGENT; SIMU
Page 79 and 80: 57 STRUCTURAL STUDIES OF LIPIDS IN
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73 THE AUTOMATED NMR LABORATORY; SP
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89 13C NMR ASSIGNMENTS OF DNA OLIGO
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105 EVALUATION OF DOUBLE TUNED CIRC
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121 BROADBAND SPIN DECOUPLING IN TH
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137 TWO-DIMENSIONAL 13C{15N}, 13C{1
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153 NMR CHARACTERIZATION OF THE SOL
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169 SPECTROSCOPY WITH EXACT APODIZA
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185 PARSING THE EDITED 1H NMR SIGNA
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. z 201 THE CORRELATION OF 1H-19F C
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i m 3 I 31p SOLID STATE NMR STUDIES
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CALCULATION OF 2951MAS NMR CHEMICAL
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AN NMR STUDY OF MISCIBLE BLENDS IN
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15 II9F CRAMPS OF INORGANIC FLUORID
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19 I DIPOLARAND SPIN-ROTATION POLAR
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2 3- I A SOLID-STATE 2H and 13C NMR
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27 1 COLLECTION OF PHOSPHORUS-31 NM
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31 DELAYED REFOCUSSING TWO-DIMENSIO
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35 DYNAMIC NUCLEAR POLARIZATION STU
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I 39 2D NMR STUDIES AT 600 MHZ OF A
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43 Coherent Averaging Theory Under
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46 CARBON-13 SPECTRAL ASSIGNMENTS O
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a b 48 SEMUT SPECTRAL EDITING, CALI
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'--- V 5 2 j INTERCONWERSION OF VAL
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[ ~ THE SOURCE OF AN ARTIFACT IN TH
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60 GLUCOSE METABOLISM IN PERFUSED H
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. °- F 64 I MICROSCOPIC IMAGING OF
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68 69 CONFORMATIONAL ANALYSIS via V
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72 I SCUBA, A MAY TOHARDS COMPLETE
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76 NMR CHARACTERIZATION OF THE GLYP
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8o I HIGH RESOLUTION MR IMAGING AT
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A PROBE WITH HIGHER DECOUPLING EFFI
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88 I SOLID STATE ll3cd I~CLEAR }~GE
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- - 92 l CHARACTERIZATION OF NORMAL
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96 AN EVALUATION OF NEW PROCESSING
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. . I00 I NOVEL RESONATOR DESIGNS,
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104 TAYLOR TRANSFORMATION OF 2D NMR
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108 PERFORMANCE COMPARISON OF DOUBL
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RECENT EXTENSIONS OF NOESYSIM, A PR
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116 ] NODIFICATIONS TO A JEOL GX270
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I 12 o I SPECIATION OF WATER IN GLA
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124 I A COMPLETELY INTEGRATED NETWO
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I-- 1 2 8 IVOLUME-SELECTIVE SIGNAL
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-- is 2 I NATURAL ABUNDANCE 13 C an
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. ° THREE-DIMENSIONAL STRUCTURE OF
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~-'-- 140 DIRECT OBSERVATION OF LON
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144 I I IH AND 13C REFOCUSED GRADIE
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~ (POSTER ABSTRACT) BARBARA LYONS/C
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1 52 I ~IR STUDY OF NAPHTHALENE TRA
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is6 I ROTATING FRAME COHERENCE TRAN
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16 0 I A 27AL MAS STUDY OF AMORPHOU
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164 I MODIFICATIOH OF A BRUKER WH-3
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IN VIVO 31p AND IH NMR SPECTROSCOPY
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. r 172 JMAGIC ANGLE SPINNING SEPAR
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2 . ° I- 176 I Michael A. Kennedy
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. o . o 180 l17o/Is NMR MICROSCOPY
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To be presented at the 29th Experim
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INHIBITION OF ALANINE RACEMASE BY T
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192 RESOLUTION ENHANCEMENT OF PHOSP
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196 1 TR FLUOROETHOXY DERIVATIVES:
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200 INTERPRETAT IION OF 13 C NHR MI
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204 RECENT PROGRESS IN HIGH RESOLUT
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Page No. ACEVEDO, H F 165 ACKERMAN,
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1:~ge No. GUO, D 200 GUO, W 196 GUO
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OPELLA, S J ORENDT, A M OTTING, G P
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ZLOTNIK-MAZORIo T ZUMBULYADIS, N Pa
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David B. Bailey USI Chemicals Co. 1
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Yvan Boulanger Univ de Montreal Ins
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Helga Cohen Univ of So Carolina Che
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F. David Doty Doty Scientific Inc.
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Alan Freyer Pennsylvania State Univ
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Gordon Hamer Xerox Research Center-
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Timothy Hyman Syracuse University 3
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Robert A Kinsey BF Goodrich 9921Bre
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Jay J. Listinsky U of Rochester-Dep
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Dale Mierke Univ of Calif, San Dieg
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Jeanne C Owens Chemistry Dept., '.1
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Gade S. Reddy DuPont Experimental S
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Charles Schramm Catalytica Assoc. I
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Richard F. Sprecher U.S. Dept of En
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Steve Unger U. C. Davis NMR Facilit
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Toni Wirthlin Varian Associates 611
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th  - 1988 - 51st ENC Conference

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