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Contents XV<br />

11 Amino Acid Transport in Plants and Transport<br />

of Neurotransmitters in Animals: a Common Mechanism? 153<br />

Tobias Müller, Wolfgang Koch, Daniel Wipf<br />

11.1 Introduction .................................................................. 153<br />

11.2 Amino Acid Transport in Animals..................................... 154<br />

11.2.1 Sodium Dicarboxylate Symporter Family<br />

(SDS, SLC1) .......................................................... 154<br />

11.2.2 The Sodium- and Chloride-Dependent<br />

Neurotransmitter Transporter Family (NTF, SLC6) ..... 156<br />

11.2.3 Cationic Amino Acid Transporters and Heteromeric<br />

AminoAcidTransporters (SLC7) ............................. 156<br />

11.2.4 The Type I Phosphate Transporter Family (SLC17) ..... 157<br />

11.2.5 The Vesicular Inhibitory Amino Acid Transporter<br />

Family (VIAAT, SLC32) .......................................... 157<br />

11.2.6 The Proton/Amino Acid Transporter<br />

Family (PAT, SLC36)............................................... 157<br />

11.2.7 The Sodium-Coupled Neutral Amino<br />

AcidTransporterFamily (SNAT, SLC38).................... 158<br />

11.3 Amino Acid Transport in Plants ........................................ 159<br />

11.3.1 Amino Acid–Polyamine–Choline Transporter Family 159<br />

11.3.2 AminoAcidTransporterFamily1 ............................ 160<br />

11.4 Conclusions and Future Prospects ..................................... 165<br />

<strong>References</strong> ............................................................................. 166<br />

12 GABA and GHB Neurotransmitters in Plants and Animals 171<br />

Aaron Fait, Ayelet Yellin, Hillel Fromm<br />

12.1 Introduction .................................................................. 171<br />

12.2 TheGABA ShuntandGABA Signaling ............................... 173<br />

12.2.1 MammalianGABASignaling................................... 173<br />

12.2.2 GABA Signaling in Plants........................................ 173<br />

12.2.3 GABATransporters................................................ 175<br />

12.3 GHB, a By-Product of the GABA Shunt<br />

anda Neurotransmitter ................................................... 177<br />

12.3.1 FromElixirofLife to Date-RapeDrug ...................... 177<br />

12.3.2 SSADH Inborn Deficiency: the Dark Side of GHB....... 178<br />

12.3.3 The GABA Shunt and Redox Imbalance:<br />

fromBacteriatoHumans........................................ 179<br />

12.3.4 The GABA Shunt, GHB,<br />

and the Redox State in Plants................................... 180<br />

12.4 Conclusions and Future Perspectives ................................. 181<br />

<strong>References</strong> ............................................................................. 181

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