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232 S.J. Roux, C. Song, C. Jeter
animal cells, although several works have used luciferin–luciferase-based
reporters localized to the ECM to obtain initial data on this critical measurement
(Joseph et al. 2003), and plant scientists are testing this approach also
in plants (Gary Stacey, University of Missouri, personal communication).
Ifandwhenapurinoceptorisidentifiedinplantsandmethodsfor
measuring changes in eATP concentration are perfected, the field of nucleotide
signaling will rapidly expand in significance, as will the field of
ectoapyrase studies. Since virtually all growth-signaling pathways are interlinked,
future breakthroughs on the impact of extracellular nucleotides
on plant growth and development will also inform diverse other fields that
focus on growth control (e.g., hormone physiology, photomorphogenesis,
gravitropism/phototropism, plant reproduction). The field of extracellular
nucleotidesignalinginplantsisinitsinfancy,andweexpectthemost
exciting insights are yet to come.
Acknowledgements. The authors thank Wenqiang Tang, Timothy Butterfield,
X. Wang, and Stephen Stout for data and valuable discussion. Research
of the authors reviewed here was supported by grants from the National
Science Foundation (IBN 0344221) and the National Aeronautics and Space
Administration (NAG2-1586 and NAG10-295).
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