Scientific and Technical Aerospace Reports Volume 39 April 6, 2001

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51
LIFE SCIENCES (GENERAL)
Includes general research topics related to plant and animal biology (non-human); ecology; microbiology; and also the origin, development, structure,
and maintenance, of animals and plants in space and related environmental conditions. For specific topics in life sciences see categories 52
through 55.
20010021839 Henry Ford Health Systems, Detroit, MI USA
High Fidelity Electronic Display of Digital Mammographs Final Report, 3 Sep. 1996 - 2 Sep. 1998
Flynn, Michael J.; Oct. 1998; 362p; In English
Contract(s)/Grant(s): DAMD17-96-1-6283
Report No.(s): AD-A385649; No Copyright; Avail: CASI; A03, Microfiche; A16, Hardcopy
We have investigated photoemissive structures which can achieve the required display performance of digital mammography.
A design utilizing a thin glass faceplate supported by a glass microcapillary array was evaluated. The original objectives of this
project was to model the performance of emissive structures and evaluate designs with high performance. With respect to performance
modeling we have; (1) developed software to describe the electric field and the trajectories of electrons and used it to study
the effect of the focusing plate electrode, (2) used electron/photon transport computations to characterize the electron backscattering
from phosphor layers, and (3) developed a simulation code to study the luminance spread function of emissive structures and
reported results for conventional CRT structures and for thin structures. With respect to the evaluation of potential designs we
have; (1) constructed a vacuum subsystem and experimental chamber into which a cathode and emissive structure can be mounted,
(2) designed, built and tested a unique cone shaped luminance probe that will measure spread function tails on actual emissive
structures. (3) Identified electron charge deposition processes that limit the utility of the originally proposed method using microcapillary
designs.
DTIC
Electric Fields; Display Devices; Photoelectric Emission; Mammary Glands
20010021843 Georgetown Univ., Medical Center, Washington, DC USA
Cell Cycle Regulation of Estrogen and Androgen Receptor Annual Report, 1 Jul. 1999 - 30 Jun. 2000
Martinez, Elisabeth D.; Jul. 2000; 16p; In English
Contract(s)/Grant(s): DAMD17-99-1-9199
Report No.(s): AD-A385514; No Copyright; Avail: CASI; A01, Microfiche; A03, Hardcopy
We seek to identify the phases in the cell cycle during which steroid-activated estrogen and androgen receptors are normally
transcriptionally active and to determine whether this cell cycle regulation of receptor activity is maintained when cancer-inducing
non- steroidal agents activate the receptors. Our hypothesis is that the activities of steroid-induced ER and AR are controlled by
cell cycle regulators and that cancer-inducing, non-steroidal activators bypass or alter this regulation of receptor activity giving
rise to aberrant ER and AR function. Through these studies we are gaining understanding of how estrogen and androgen receptors
may contribute to the onset of tumors and to the development of hormone independent growth. We have found that the activity
of the androgen and estrogen receptors is indeed regulated throughout the cell cycle with no activity of the androgen receptor in
the G2/Phase phase and low activity of the estrogen receptor in cells which are mainly in S phase. Furthermore, our data indicate
that non-steroidal activators of the receptors may act in a cell type and promoter dependent manner as we do not detect receptor
activation by growth factors in our system.
DTIC
Steroids; Estrogens; Sense Organs; Growth; Cancer
20010021844 University of South Florida, Tampa, FL USA
Weight Gain in Breast Cancer Patients on Chemotheraphy: Exploring Hormonal Body Composition and Behavioral
Mechanisms Annual Report, 1 Sep. 1998-31 Aug. 1999
Kumar, Nagi B.; Sep. 1999; 10p; In English
Contract(s)/Grant(s): DAMD17-98-1-8240
Report No.(s): AD-A385507; No Copyright; Avail: CASI; A02, Hardcopy; A01, Microfiche
The purpose of this study is to prospectively and systematically observe the relative contribution of each viable mechanism
such as nutritional intake, activity levels, body composition, hormonal function, thyroid function, coping mechanisms and fatigue
scores during chemotherapy on weight gain in breast cancer patients. If changes in the above factors contribute to weight gain
and thus alter prognosis, manipulation of these variables by timely intervention may improve prognosis and facilitate recovery
from breast cancer. Progress: As planned and described in the Statement of Work, Task 1 of recruitment and data collection and