Scientific and Technical Aerospace Reports Volume 39 April 6, 2001
Scientific and Technical Aerospace Reports Volume 39 April 6, 2001
Scientific and Technical Aerospace Reports Volume 39 April 6, 2001
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<strong>2001</strong>0025766 Michigan Univ., Ann Arbor, MI USA<br />
NMR Reconstructive Elasticity Imaging of Breast: Surrogate Remote Palpation Using Quantitative 3-D Displacement <strong>and</strong><br />
Strain Estimations Annual Report, 11 Aug. 1998-10 Aug. 1999<br />
Chensvert, Thomas L.; Sep. 1999; 47p; In English<br />
Contract(s)/Grant(s): DAMD17-97-1-7079<br />
Report No.(s): AD-A385921; No Copyright; Avail: CASI; A03, Hardcopy; A01, Microfiche<br />
The goal of this research program is to develop a sensitive diagnostic technique based on quantitative elasticity imaging permitting<br />
surrogate palpation of deep lying breast lesions. The remote measurement of elasticity in breast tissues may provide unique<br />
information which could increase detection <strong>and</strong>/or characterization of potentially malignant masses not accessible to manual<br />
palpation. The primary technical objective of this study is to refine <strong>and</strong> test an MRI method for the acquisition of high resolution<br />
3- dimensional (3D) spatial displacement data through the imaged object for quantitative estimation of internal strain <strong>and</strong> elastic<br />
modulus. Proof-of-concept of the proposed 3D displacement-encoding, stimulated echo technique has been completed <strong>and</strong> published<br />
using two-dimensional test objects. A pneumatically-driven deformation device under acquisition sequence control has<br />
been designed, constructed, <strong>and</strong> demonstrated to produce highly reproducible deformations of the imaged object. The image<br />
acquisition sequence has been generalized to encode 3D displacements over a 3D volume using ”classic” 3D <strong>and</strong> fast-spin- echo<br />
schemes. <strong>Volume</strong>tric datasets of 3D phantoms have been acquired <strong>and</strong> submitted for processing using newly developed 3D elasticity<br />
reconstruction algorithms. Comparisons between 2D <strong>and</strong> 3D elasticity reconstructions from simulated <strong>and</strong> experimental displacement<br />
data shows higher accuracy of the 3D elasticity reconstruction.<br />
DTIC<br />
Cancer; Nuclear Magnetic Resonance; Imaging Techniques; Tissues (Biology)<br />
<strong>2001</strong>0025767 Pennsylvania Univ., Medical Image Processing Group, Philadelphia, PA USA<br />
Breast Images with Diffusing Light Waves Final Report, 1 Sep. 1997-31 Aug. 1999<br />
Yodh, Arjun G.; Nov. 1999; 95p; In English; Original contains color plates<br />
Contract(s)/Grant(s): DAMD17-97-1-7272<br />
Report No.(s): AD-A385922; No Copyright; Avail: CASI; A05, Hardcopy; A01, Microfiche<br />
Our work over the last year aimed to develop <strong>and</strong> assess the utility of various theoretical <strong>and</strong> experimental diffuse light imaging<br />
schemes for tumor detection <strong>and</strong> characterization within the human breast. We have theoretically <strong>and</strong> numerically investigated<br />
the angular spectrum approach in the parallel plate (compressed breast) geometry. One paper investigated the use of depth dependent<br />
regularization <strong>and</strong> mathematical filtering methods to improve the fidelity of these projection images in the presence of noise.<br />
In a related publication we documented a group of refinements to the diffraction tomographic techniques. On the experimental<br />
side we have built a soft compression plate apparatus for diffuse optical tomography of the breast. The device was used to experimentally<br />
to test the angular spectrum <strong>and</strong> other theoretical approaches. Through this work we uncovered some technical limitations<br />
of diffuse optical tomography based on the angular spectrum approach, <strong>and</strong>, importantly, we developed other schemes for<br />
improved breast imaging. In this vein we derived a new integro-differential equation for bounded media within the diffusion<br />
approximation, which makes possible full 3D reconstruction in the compressed breast geometry.<br />
DTIC<br />
Tomography; Cancer; Imaging Techniques; Differential Equations; Approximation<br />
<strong>2001</strong>0025770 Cell Works, Inc., Baltimore, MD USA<br />
Concurrent Measurement of Growth <strong>and</strong> Cell Arrest Markers, Aneuploidy <strong>and</strong> Estrogen Receptor Status of Circulating<br />
Breast Cancer Cells Annual Report, 1 Jun. 1999 - 31 May 2000<br />
Lesko, Stephen; Jun. 2000; 34p; In English<br />
Contract(s)/Grant(s): DAMD17-99-1-9117<br />
Report No.(s): AD-A385381; No Copyright; Avail: CASI; A01, Microfiche; A03, Hardcopy<br />
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