Scientific and Technical Aerospace Reports Volume 39 April 6, 2001
Scientific and Technical Aerospace Reports Volume 39 April 6, 2001
Scientific and Technical Aerospace Reports Volume 39 April 6, 2001
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withdrawal <strong>and</strong> no positive immunostaining for PCNA was observed. In contrast, the prostates from 35 day post-castration MTR4<br />
<strong>and</strong> MTR27H mice had regressed to: AP 30% <strong>and</strong> 34%, DLP 81% <strong>and</strong> 57% <strong>and</strong> VP 50% <strong>and</strong> 33% respectively.<br />
DTIC<br />
Histology; Prostate Gl<strong>and</strong>; Cancer<br />
<strong>2001</strong>002<strong>39</strong>28 John P. Robarts Research Inst., London, Ontario Canada<br />
Prediction of Malignancy in Breast Tumors Using Diffusion Weighted Magnetic Resonance Imaging Annual Report<br />
Gareau, Paul; Rutt, Brian K.; Jul. 2000; 12p; In English<br />
Contract(s)/Grant(s): DAMD17-99-1-9227<br />
Report No.(s): AD-A385709; No Copyright; Avail: CASI; A01, Microfiche; A03, Hardcopy<br />
The purpose of this research is to develop a non-invasive predictor of malignancy in breast tumors using novel magnetic resonance<br />
imaging (MRI) techniques. The hypothesis is that the spatial distribution of microvasculature around a breast lesion is specific<br />
for malignancy <strong>and</strong> can be reliably measured by a completely non-invasive MRI method. This hypothesis is being tested by:<br />
(1) The design <strong>and</strong> construction of ultra-high gradient coils for MRI. (2) The implementation of advanced MRI pulse sequences<br />
for mapping of microvascular parameters, <strong>and</strong> (3) The correlation of MRI-derived vascular parameters (diffusion <strong>and</strong> perfusion)<br />
with histological parameters (tumor grade <strong>and</strong> microvessel density) in an animal model of human breast cancer.<br />
DTIC<br />
Cardiovascular System; Cancer; Mammary Gl<strong>and</strong>s; Magnetic Resonance; Imaging Techniques<br />
<strong>2001</strong>0024026 Colorado Univ., Health Sciences Center, Denver, CO USA<br />
Chemotherapy of Late Stage Breast Cancer Targeted Towards Cell Cycle Regulatory Components Annual Report, 15 Sep.<br />
1998-14 Sep. 1999<br />
Langan, Thomas, Colorado Univ., USA; Oct. 2000; 27p; In English<br />
Contract(s)/Grant(s): DAMD17-98-1-8299<br />
Report No.(s): AD-A384617; No Copyright; Avail: CASI; A01, Microfiche; A03, Hardcopy<br />
We have investigated two drugs which target cell cycle regulatory components as potential cancer chemotherapeutic agents<br />
for use in late stage breast cancer. The first, 5,6-dihydro-5-azacytidine (DHAC), a DNA methylation inhibitor, has been tested<br />
for its potential to reduce unregulated growth in cultured breast cancer cell lines which fail to express the cyclin-dependent kinase<br />
inhibitor protein p16 due to p16 gene methylation. DHAC was found to significantly affect the growth <strong>and</strong> cell cycle distribution<br />
of cultured T47-D breast cancer cells. However, this was not accompanied by detectable expression of p16 protein in these cells.<br />
We are currently employing a related methylation inhibitor, 5-aza-2 deoxycytidine, in attempts to optimize conditions for promotion<br />
of detectable p16 expression, since this has the potential to produce greater reductions in cell growth as well as in tumorigenic<br />
properties. The second drug studied, bryostatin-1, promotes expression of another type of cyclin-dependent kinase inhibitor, p21.<br />
DTIC<br />
Chemotherapy; Cancer; Mammary Gl<strong>and</strong>s; Regulatory Mechanisms (Biology); Cells (Biology); Inhibitors; Proteins<br />
<strong>2001</strong>0024033 City Univ. of New York, Research Foundation, NY USA<br />
Breast Cancer Screening Using Photonic Technology Annual Report, 15 Aug. 1998-14 Aug. 1999<br />
Alfano, Robert R.; Sep. 1999; 37p; In English<br />
Contract(s)/Grant(s): DAMD17-98-1-8147<br />
Report No.(s): AD-A384638; No Copyright; Avail: CASI; A03, Hardcopy; A01, Microfiche<br />
The goal of the research is to develop a noninvasive modality that uses non-ionizing near-infrared (NIR) light for imaging<br />
<strong>and</strong> diagnosis of cancerous lesions of human breast. The imaging method involves illuminating the specimen with ultrashort<br />
pulses of NIR laser light <strong>and</strong> construction of images using two approaches: the shadowgram method, <strong>and</strong> the three dimensional<br />
(3-D) inverse reconstruction method. During this reporting period we set up: (a) time sliced imaging arrangements using an electronic<br />
time gate, <strong>and</strong> optical Kerr gates; (b) a spectroscopic imaging arrangement to explore the diagnostic potential of optical<br />
methods; <strong>and</strong> (c) a 3-D inverse reconstruction method that uses the diffusion approximation of the radiative transport theory as<br />
the light propagation model, <strong>and</strong> time-sliced two-dimensional transmitted light intensity data for inversion to obtain images of<br />
thick samples.<br />
DTIC<br />
Cancer; Photons; Mammary Gl<strong>and</strong>s; Imaging Techniques<br />
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