Psiquiatria - Faculdade de Medicina - UFMG
Psiquiatria - Faculdade de Medicina - UFMG
Psiquiatria - Faculdade de Medicina - UFMG
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
Transtorno afetivo bipolar resistente e revisão <strong>de</strong> seu tratamento com clozapina<br />
Summary<br />
The authors report a case of resistant bipolar disor<strong>de</strong>r followed in<br />
the last five years at the Psychiatric Service of the Hospital das<br />
Clínicas - <strong>UFMG</strong>. Many treatments were indicated, such as lithium,<br />
carbamazepine, oxacarbamazepine, valproate, verapamil, benzodiazepines,<br />
traditional antipsychotics and polipharmacotherapy.The use<br />
of clozapine, which was succesful, was chosen due to many data in<br />
the literature showing it as an alteranative treatment for bipolar disor<strong>de</strong>r.<br />
Key-words: Bipolar Disor<strong>de</strong>r; Clozapine<br />
Referências Bibliográficas<br />
1. Prien RF, Gelenberg AJ. Alternatives to lithium for preventative<br />
treatment of bipolar disor<strong>de</strong>r. Am J Psychiatry 1989;<br />
146:840-8.<br />
2. Dunner DL, Fieve RR. Clinical factors in lithium carbonate<br />
prophylaxis failure. Arch Gen Psychiatry 1974; 30:229-33.<br />
3. Davis KL, Berger PA, Holister LE. Tardive dyskinesia and<br />
<strong>de</strong>pressive illness. Psychopharmacology Communications<br />
1976; 2:125-30.<br />
4. Small JG, Klapper MH, Milstein V et al. Carbamazepine<br />
compared with lithium in the treatment of mania. Arch Gen<br />
Psychiatry 1991; 48:15-921.<br />
5. Calabrese JR, Woyshville MJ, Kimmel SE, Rapport DJ. Predictors<br />
of valproate response in bipolar rapid cycling. J Clin<br />
Psychopharmacol 1993; 13:280-3.<br />
6. Medical Practice Project. A State of the Art Science Report<br />
for the Office of the Assistant Secretary for the US Department<br />
of Health Education and Welfare. Baltimore: Policy<br />
Research, 1979.<br />
7. Ghaemi SN, Sachs GS, Baldissano CF. Treatment-resistant<br />
bipolar disor<strong>de</strong>r: clinical aspects and management. In:<br />
Pollack M, Rosenbaum JF ed. Challenges in psychiatric treatment:<br />
pharmacologic and psychosocial strategies. New York:<br />
Guildford; 1996:53-85.<br />
8. Sernyak MJ, Griffin RA, Johnson RM, Peassal HR, Wexler<br />
BE, Woods JW. Neuroleptic exposure following inpatient<br />
treatment of acute mania with lithium and neuroleptic. Am J<br />
Psychiatry 1994; 151:133-5.<br />
9. Mar<strong>de</strong>r SR, Van Putten T. Antipsychotic medications. In:<br />
Schatzberg AF, Nemeroff CB. ed. Textbook of psychopharmacology.<br />
Washington DC: American Psychiatric Press,<br />
1995:247-62.<br />
32 Casos Clin Psiquiat 1999; 1(1):27-32<br />
10. Saltz BL, Woener MG, Kane JM et al. Prospective study of<br />
tardive dyskinesia in the el<strong>de</strong>rly. JAMA 1991; 266:2402-06.<br />
11. Mc Elroy SL, Dessain EC, Pope Jr HG et al. Clozapine in the<br />
treatment of psychotic mood disor<strong>de</strong>rs, schizoaffective disor<strong>de</strong>r,<br />
and schizophrenia. J Clin Psychiatry 1991; 52:411-4.<br />
12. Banov MD, Zarrate Jr CA, Tohen M et al. Clozapine therapy<br />
in refratory affective disor<strong>de</strong>rs: polarity predicts response in<br />
long term follow-up. J Clin Psychiatry 1994; 55:295-300.<br />
13. Zarate Jr CA, Tohen M, Bal<strong>de</strong>ssarini RJ. Clozapine in severe<br />
mood disor<strong>de</strong>rs. J Clin Psychiatry 1995; 56:411-7.<br />
14. Zarate Jr CA, Tohen M, Banov M et al. Is Clozapine a mood<br />
stabilizer? J Clin Psychiatry 1995;56:108-12.<br />
15. Patel JK, Green AI, Banov MD et al. Clozapine use in treatment<br />
refratory mania and psychosis. In: New Research Programs<br />
and Abstracts of the 148th Annual Meeting of the<br />
American Psychiatric Association; May 1995, Miami, Abstract<br />
N.R. 478:183.<br />
16. Frankenburg FR, Zanarini MC Uses of Clozapine in nonschizophrenic<br />
patients. Harvard Rev Psychiatry 1994; 2:142-150.<br />
17. Naber D, Hippius H. The European Experience with use of<br />
Clozapine. Hosp Comm Psych August 1990; 41(8):886-90.<br />
18. Calabrese JR, Meltzer HY, Markovitz PJ. Clozapine prophylaxis<br />
in rapid cycling bipolar disor<strong>de</strong>r (letter) J Clin Psychopharmacol<br />
1991; 11(6):396-7.<br />
19. Suppes T, McElroy SL, Gilbert J, Dessain EC, Cole JO. Clozapine<br />
in the treatment of dysphoric mania. Biol Psychiatry<br />
1992; 32:270-280.<br />
20. Kimmel SE, Calabrese JR, Woyshville MJ, Meltzer HY. Clozapine<br />
in treatment-refractory mood disor<strong>de</strong>rs. J Clin<br />
Psychiatry 1994; 55(9-Suppl. B):91-3.<br />
21. Haller E, Bin<strong>de</strong>r RL. Clozapine and seizures. Am J<br />
Psychiatry 1990; 147:1069-71.<br />
22. Kando JC, Tohen M, Castillo J, Centorrino F. Concurrent use<br />
of clozapine and valproate in affective and psychotic disor<strong>de</strong>rs.<br />
J Clin Psychiatry 1994; 55(6)255-7.<br />
23. Centorrino F, Bal<strong>de</strong>ssarini RJ, Kando J et al. Serum concentrations<br />
of clozapine and its major metabolites: effects of cotreatment<br />
with fluoxetine or valproate. Am J Psychiatry<br />
1994; 151:123-5.<br />
Trabalho apresentado como poster e premiado entre os cinco<br />
melhores no IX Congresso Mineiro <strong>de</strong> <strong>Psiquiatria</strong> e II Jornada<br />
Su<strong>de</strong>ste <strong>de</strong> <strong>Psiquiatria</strong>, junho <strong>de</strong> 1999, Associação Médica <strong>de</strong><br />
Minas Gerais, Belo Horizonte.