Ştiinţe Medicale - Academia de Ştiinţe a Moldovei

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Wu Y.W., Backstrand K.H., Zhao S. et al. Decliningdiagnosis of birth asphyxia in California: 1991-2000. Pediatrics,2004; 114:1584.33. Yamashita K. et al. Post-occlusion treatment withBDNF reduced infarct size in a model of permanent occlisionin the middle cerebral artery in rat. Metabolic Brain Disease,1997; 12 (4):271-280.34. Yan Q. et al. Expression of brain-derived neurotrophicfactor protein in the adult rat central nervous system.Neiroscience, 1997; 78 (2):431-448.35. Yoshimura R., Ito K., Endo Y. Differentiation/maturationof neuropeptide Y neurons in the corpus callosumis promoted by brain-derived neurotrophic factor in mousebrain slice cultures. Neuros. Lett, 2008; 16 Dec.RezumatÎn studiul prezent au fost apreciate nivelele plasmaticeale factorului neurotrofic BDNF la copiii cu leziuni hipoxicoischemiceperinatale (EHIP) de diferit grad, în perioadaacută și în cea de recuperare. Nivele foarte scăzute de BDNFse apreciau la copiii cu leziuni grave ale SNC. S-a presupus,că BDNF este o neurotrofină responsabilă de neurodezvoltarela naștere și în perioada de creștere. S-a constatat, căvalorile înalte de BDNF (la copiii cu grad ușor și mediu deafectare a SNC) ameliorează procesele neurometabolice șineuroplastice la copilul în creștere, protejează creierul dedistrucţie, susţin supraveţuirea și diferenţierea neuronilor.Valorile scăzute de BDNF constituie un criteriu obiectiv deprognostic al dizabilităţilor neuropsihice și motorii la nounăscut.În EHIP de grad sever procesele de neurogenezăse decompensează și neuronii corticali nu sunt protejaţide destrucţiune. Nivelul scăzut al factorului neurotrofic,în acest caz, nu este suficient pentru a menţine la nivelulcuvenit procesele de neurotroficitate și neuroregenerare.Administrarea unui exces de factori neurotrofici ar protejaţesuturile cerebrale sensibile contra leziunilor hipoxicoischemiceși ar conduce la ameliorarea neurodezvoltării și lascăderea gradului de invaliditate.SummaryIn this study we appreciated the brain-derived neurotrophicfactor (BDNF) in the serum of children with diversegrade perinatal hypoxic-ischemic injuries (PHIE) in acuteand retrieval periods. A higher level of BDNF is associatedto a better protection of brain against destruction, maintainsthe neuronal survival and differentiation. The lowBDNF level in serum of newborns with PHIE constitutesan objective criterion in prognostic of neuropsychical andmotor disabilities. In severe PHIE the processes of neurogenesisare decompensated and the cortical neurons are notprotected against destruction. In this case, the low BDNFlevel is not sufficient to maintain efficiently the processes ofneurotrophicity and neuroregeneration. Administration ofneurotrophic factor excess protects sensible cerebral tissuesagainst hypoxic-ischemic injuries.