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Ştiinţe Medicale - Academia de Ştiinţe a Moldovei

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Ştiinţe <strong>Medicale</strong>and risk of stroke in patients with asymptomatic internal-carotid-arterystenosis. North American Symptomatic CarotidEndarterectomy Trial Collaborators. N. Engl. J. Med., 2000;342:1693–1700.10. Grosu A. Fibrilaţia atrială, Chișinău, 2006, p. 22,64.11. Watson T., Shantsila E., Lip G. Y. Mechanisms ofthrombogenesis in atrial fibrilla tion: Virchow’s triad revisited.Lancet, 2009; 373:155–166.12. Al-Saady N. M., Obel O. A., Camm A. J. The leftatrial appendage: structure, function and role in thromboembolism,Heart., 1999; vol. 82:547-555.13. Roldan V., Marin F., Marco P. et al. Hypofibrinolysisin atrial fibrillation, Amer. Heart J. – 1998, vol.136:956-960.14. Goldsmith I., Blann A.D., Patel R.L. et.al. Reducedindices of left atrial hypercoagulability in patients with severemitral regurgitation. Amer. J. Cardiology, 2000, vol. 86:234-236.15. Fuster V., Ry<strong>de</strong>n L., Asinger R. et al. 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Predictors of major vascular events in patients withtransient ischaemic attack or minor stroke and non-rheumaticatrial fibrillation. EAFT Study Group. Stroke, 1995,vol.26:801-806.22. Vermeer Se et al. Asymptomatic stroke. Lancet Neurol.,2007; 6:611-9.23. Dickstein K., Cohen-Solal A., Filippatos G. et al.ESC Gui<strong>de</strong>lines for the diagnosis and treatment of acute andchronic heart failure 2008. Eur. Heart. J., 2008; 29:2388–2442.24. Stroke in AF working group. In<strong>de</strong>pen<strong>de</strong>nt predictorsof stroke in patients with atrial fibrillation: a systematicreview. Neurology., 2007; 69:546–554.25. Autors/ Task Force Members: A. John Camn, PaulusKirchhof, Gregory Y. H. Lip Gui<strong>de</strong>lines for the managementof atrial fibrillation. European Heart. J., 2010; 31:2369-2429.26. Шевченко О.П. Артериальная гипертония ицеребральный инсульт.М: Реафарм 2001; 191.27. Taylor A.J., Kent S.M., Flaherty P.J. et al. ARBITER:Arterial Biology for the Investigation of the Treatment Effects51of Reducing Cholesterol: a randomized trial comparing theeffects of atorvastatin and pravastatin on carotid intima medialthickness. Circulation, 2002; 106:2055-60.28. Д.В. Преображенский. Инсульт и другиетромбоэмболические осложнения при мерцаниипредсердий. Часть I. Распространенность и факторыриска. Кардиология, 2004; 3:83-86.29. People with diabetes are at higher risk of atrial fibrillation,Published: Thursday, 2010; 18:12 in Health &Medicine.30. Gregory Y. H., Watson T., Shantsila E. Anticoagulationfor stroke prevention in atrial fibrillation: is gen<strong>de</strong>rimportant? Euro Heart. J., 2006; 27:1893-1894.31. Fang M.C., Singer DE., Chang Y. et al. Gen<strong>de</strong>r differencesin the risk of ischemic stroke and peripheral embolismin atrial fibrillation,(ATRIA) study. Circulation, 2005;112:687–1691.32. Amarenco P., Tonkin A.M. Statins for stroke prevention:disappointment and hope. Circulation., 2004;109:III-44–III-49.33. Marcucci R., Betti I., Cecchi E., et al. Hyperhomocy-steinemiaand vitamin B6 <strong>de</strong>ficiency: new risk markersfor nonvalvular atrial fibrillation? Am. Heart. J. 2004;148:456-61.34. Fontaine K.R., Red<strong>de</strong>n D.T., Wang C. et al. Years oflife lost due to obesity. JAMA. 2003; 289:187–193.35. Sascha Dublin et al. Influence of high body in<strong>de</strong>xto risk of atrial fibrillation and stroke. Arch. Intern. Med.,2007;166:2322-2328.36. Towfighi Amytis et al. NHANES (National Healthand Nutrition Examination Survey) 1999-2004. Neurulogy,2007; advance online publication.37. Conway D.S.G., Buggin P., Hughes E. et al. Relationof interleukin-6, C-reactive protein, and the prothromboticstate to transesophageal echocardiographic findings inatrial fibrillation. Am. J. Cardiol., 2004; 93:1368-1373.38. Д-р F. Purroy и коллеги (УниверситетскаяКлиника Arnau <strong>de</strong> Villanova, Lleida, Испания).С-реактивный белок предсказывает риск повторныхсосудистых событий. Acta Neurol. Scand., 2007; 15:60-66.39. Koen Putman. Образовательный уровеньинсультных больных определяет ответ нареабилитацию в стационаре, уровень дохода -восстановление после выписки. J. Neurol. Neurosurg.Psychiatry, 2006; advance online publication 25.12.2006.RezumatLucrarea <strong>de</strong> faţă își propune să analizeze principaliifactori <strong>de</strong> risc <strong>de</strong> <strong>de</strong>zvoltare a acci<strong>de</strong>ntelor vascularecerebrale ischemice și impactul lor la bolnavii cu FA,<strong>de</strong>oarece această patologie este extrem <strong>de</strong> răspândităși are costuri economico-sociale ridicate. Ictusul esteo afecţiune heterogenă multifactorială, influenţată <strong>de</strong>factori <strong>de</strong> risc modificabili și nemodificabili. Factorii<strong>de</strong> risc modificabili includ anamneza <strong>de</strong> hipertensiunearterială, diabet zaharat și cardiopatie ischemică. Factorii<strong>de</strong> risc nemodificabili includ vârsta, genul și rasa.Alţi factori <strong>de</strong> risc mai puţin documentaţi sunt locali-

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