situ hibridizasyon yöntemi i - Çukurova Üniversitesi

115. Liu MC, Gelmann EP: P53 gene mutations: case study of a clinical markers for solid tumors.
Semin Oncol 2002; 29: 246
116. Greenblatt MS, Bennett WP, Hollstein M, Harris CC Mutations in the p53 tumor suppressor
gene: clues to cancer etiology and molecular pathogenesis. Cancer Res 1994; 54:4855–78
117. Gruis NA, van der Velden PA, Sandkuijl LA, et al: Homozygotes for CDKN2 (p16) germline
mutation in dutch familial melanoma kindreds. Nat Genet 1995; 10:351-353.
118. Smith-Sorensen B, Hovig E: CDKN2A (p16INK4A) somatic and germline mutations. HumMutat
1996; 7: 294-303.
119. Liggett WH Jr, Sidransky D: Role of the p16 tumor suppressor gene in cancer. J Clin Oncol
1998; 16: 1197-1206.
120. Honda R, Yasuda H: Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of
Mdm2 for tumor suppressor p53. EMBO J 1999; 18: 22-27
121. Lowe SW, Sherr CJ: Tumor suppression by Ink4a-arf: Progress and puzzles. Curr Opin Genet
Dev 2003; 13: 77-83,
122. Yamada KM, Araki M Tumor suppressor PTEN: modulator of cell signaling, growth, migration
and apoptosis. J Cell Sci 2001; 114:2375–82
123. Chen Z, Trotman LC, Shaffer D, Lin HK, Dotan ZA, Niki M et al. Crucial role of p53dependent
cellular senescence in suppression of Pten-deficient tumorigenesis. Nature 2005;
436:725–30
124. Veeman M. T, J. D. Axelrod & R. T. Moon: A second canon. Functions and mechanisms of
beta-cateninin dependent Wnt signaling. Dev Cell 2003; 5, 367-377.
125. Goding CR: Mitf from neural crest to melanoma: Signal transduction and transcription in the
melanocyte lineage. Genes Dev 14: 2000: 1712-1728
126. Widlund HR, Fisher DE: Microphthalamiaassociated transcription factor: A critical regulator of
pigment cell development and survival. Oncogene 2003; 22:3035-3041.
127. Ramirez RD, D’Atri S, Pagani E, Faraggiana T, Lacal PM, Taylor RS, Shay JW: Progressive
increase in telomerase activity from benign melanocytic conditions to malignant melanoma.
Neoplasia 1999; 1:42–49
128. Mathon NF, Lloyd AC: Cell senescence and cancer. Nat Rev Cancer 2001; 1:203–21
100