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Z. HOSSEINI AND A. GHALEHJOUGHI / ISEM2016 Alanya – Turkey [16] Bampurad. The Jewish war ethics. Tehran: Markaz. 2009. [17] Shirazi, M.H. Al-Fiqh al-bi’ah. Beirut: Muassisah al-waei al-Islami. 1999. [18] Ibn Faris. Al-Maqabis al-luqah. Qom: Maktabah al-a’lam Islami. 1994. [19] Farahidi. Al-Ain. Qom: Hejrat. 1984. [20] Gaeett. V.S. Conservation laws in modern physics. Hodhod Journal, 1981. (27) 592- 604. [21] Gaeett Hardin, The traged of commons , scinences,1968,162. 1243-1248. [22] Khalid Fazlun, 2010, The Envoirment in Islsm, 15 th conference , Jordan 558
ISEM2016, 3 rd International Symposium on Environment and Morality, 4-6 November 2016, Alanya – Turkey Which Environment Makes Cancer? 1 Asuman Deveci, * 1 Suleyman Kaleli and 1 Gamze Guney Eskiler * 1 Faculty of Medicine, Department of Medical Biology, Sakarya University, Turkey Abstract: Cancer occurs with uncontrolled cell growth or abnormal cell division in DNA damage. Carcinogens are the factors that cause DNA mutations and they are known to cause cancer in our body by making changes in gene level. Genetic susceptibility is also important in cancer development along with factors such as poor living conditions. Additionally, all these environmental factors such as X-rays, gamma rays, the radiation emitted from radioactive materials, aniline type dyes, cigarette, free radicals, asbestos, silica dust, air pollution, food additives, various drugs, some of the chemicals used in perfumes, oncogenic viruses and bacteria are playing an important role in cancer formation and contribute the increase of incidence of cancer. The environmental factors that cause cancer are located in air, water, soil and the food that we need to live. Consequently, human get cancer from exposure to carcinogens from the environment where they live. The cancer is a difficult disease to treat and reduces the life quality of people with cancer. Investigation of the effects of environmental factors in cancer and prevention of the cancer development by determining the factors that cause cancer are very important from this perspective. Key words: Environment, carcinogens, cancer, DNA, mutation 1. Introduction Cancer, which is the second leading cause of death, is a group of disease involving abnormal cell growth with the potential to invade or spread to other parts of the body. [1,2]. According to GLOBOCAN, there were 14.1 million new cancer cases, 8.2 million cancer deaths and 32.6 million people living with cancer [within 5 years of diagnosis in 2012 worldwide. On the other hand, it is estimated that 1,685,210 new cases of cancer will be diagnosed in the United States and 595,690 people will die from the disease in 2016. Thus, there is an urgent need for a new therapeutic strategy to reduce cancer-related deaths [3,4]. Cancer is a multifactorial disease and so, many genetic and environmental factors increase the risk of developing cancer, such as viruses, bacteria, radiation, genetic and eating habits and chemicals [3-8] [Figure 1]. 10-15% of all cancers are thought to be related to an inherited gene, whereas, the remaining 85-90% of cancer have their roots in the environment and lifestyle. It is known that all cancer-related deaths, almost 25–30% are due to tobacco, approximately 30–35% are linked to diet, nearly 15–20% are due to infections, and the remaining percentage is due to other factors like radiation, stress, physical activity, environmental pollutants, etc. [9]. In terms of genetic factors, mutations in a few genes, including oncogenes, tumor suppressor genes and DNA repair genes can lead to cancer formation rather than a single gene. These genes cause cancer through three main biologic pathways [cell cycle, apoptosis and differentiation], which are normally, regulate tissue *Corresponding author: Address: 1 Faculty of Medicine, Department of Medical Biology, Sakarya University, 54187, Sakarya TURKEY. E-mail address: skaleli@sakarya.edu.tr, Phone: +902642953117 559
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