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Protein Expression and Purification Series - Bio-Rad

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APPENDIX J<br />

REFERENCES, LEGAL<br />

NOTES & TRADEMARKS<br />

<strong>Protein</strong> <strong>Expression</strong> <strong>and</strong> <strong>Purification</strong> <strong>Series</strong><br />

Appendix J: References, Legal Notices, <strong>and</strong> Trademarks<br />

<strong>Bio</strong>technology Institute <strong>Bio</strong>tech Timeline http://www.biotechinstitute.org/teachers/resources/timeline<br />

Drug Development Timeline http://www.wellcome.ac.uk/bigpicture/drug/runflash2.html<br />

http://www.malariajournal.com/content/6/1/108<br />

http://www.pnas.org/content/94/20/10931<br />

http://www.who.int/topics/malaria/en/<br />

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=full_report&list_uids=1719<br />

http://www.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb34_1.html<br />

http://www.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb34_3.html<br />

http://ghr.nlm.nih.gov/chromosome/5<br />

http://beta.docguide.com/dihydrofolate-reductase-deficiency-due-homozygous-dhfr-mutation-causesmegaloblastic-anemia-<strong>and</strong>-cere?tsid=5<br />

The American biotechnology industry has surpassed pharmaceutical companies for the third straight year<br />

as the primary source of new medicines, <strong>and</strong> biotech revenue jumped nearly 16 percent to a record $50.7<br />

billion in 2005. Ernst & Young LLP, 2006.<br />

The biocompatible materials market is estimated to reach nearly $11.9 billion by 2008. <strong>Bio</strong>materials<br />

are used in every medical device meant for body contact, form orthopedic implants <strong>and</strong> bone grafts to<br />

coronary stents <strong>and</strong> soluble sutures. <strong>Bio</strong>compatible Materials for the Human Body, 2003.<br />

The biotech industry has mushroomed since 1992, with U.S. healthcare biotech revenues increasing from<br />

$8 billion in 1993 to $39 billion in 2003. <strong>Bio</strong>technology Industry Organization (BIO), 2006.<br />

<strong>Bio</strong>technology is one of the most research-intensive industries in the world. The U.S. biotech industry spent<br />

$17.9 billion on research <strong>and</strong> development in 2003. <strong>Bio</strong>technology Industry Organization (BIO), 2006.<br />

Resources<br />

http://chemtools.chem.soton.ac.uk/projects/emalaria/index.php?page=1 (This site may be of interest to<br />

teachers, although the project is currently on hold.)<br />

DHFR the Movie, from Kraut Research Group at University of California at San Diego: http://chem-faculty.<br />

ucsd.edu/kraut/dhfr.html<br />

Expasy <strong>Protein</strong> Parameters tool: http://expasy.org/tools/protparam.html<br />

(Genscript tools; http://www.genscript.com/cgi-bin/tools/codon_freq_table).<br />

Add a table of the codon sites here or in Appendix G References? A<br />

nother codon usage table: http://www.kazusa.or.jp/codon/ (This site is referenced a lot in my search for<br />

a non-commercial site. It is commercial, but the links to it, I think speak for it). Another useful site http://<br />

molbiol-tools.ca/Translation.htm (This is from Dr Kropinski at University of Guelph)<br />

246 Appendix J: References, Legal Notices, <strong>and</strong> Trademarks

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