Review

«.«‘∑¬. ¡¢. 39(1) 120-129 (2554) KKU Sci. J.39(1) 120-129 (2011)
°“√«‘‡§√“–ÀåÀ“ª√‘¡“≥ “√°≈ÿà¡´—≈‚øπ“‰¡¥åÕ¬à“ßßà“¬
„πµ—«Õ¬à“߬“¥â«¬‡∑§π‘§ ‡ª§‚µ√‚ø‚µ‡¡µ√’‚¥¬„â
8 - ‰Œ¥√Õ°´’§«‘‚π≈’π‡ªìπ√’‡Õ‡®πµå„π°“√∑”ªØ‘°‘√‘¬“√à«¡
Simple Analytical Method for the Determination of
Sulfonamides in Pharmaceutical Preparations by
Spectrophotometry Using 8-Hydroxyquinoline
as Coupling Reagent
Õ√‘»√“ ®√“°√ 1 «‘¿“√—µπå ‡◊ÈÕ«¥ 1* ·≈– √—µπ“ π—Ëπ‡¡◊Õß 1
∫∑§—¥¬àÕ
„πß“π«‘®—¬π’ȉ¥âæ—≤π“«‘∏’°“√«‘‡§√“–ÀåÀ“ª√‘¡“≥ “√°≈ÿà¡´—≈‚øπ“‰¡¥å¥â«¬‡∑§π‘§ ‡ª§‚µ√‚ø‚µ‡¡µ√’
´÷Ëßßà“¬ √«¥‡√Á« ·≈–¡’§«“¡®”‡æ“–‡®“–®ß„π°“√«‘‡§√“–Àå Ÿß ´÷ËßÕ“»—¬À≈—°°“√‡°‘¥ªØ‘°‘√‘¬“¢Õß “√Õπÿæ—π∏å°≈ÿà¡
´—≈‚øπ“‰¡¥å°—∫ 8 - ‰Œ¥√Õ°´’§«‘‚π≈’π ‚¥¬∑”ªØ‘°‘√‘¬“√à«¡°—∫ ´—≈ø“‡¡∑Õ°´“‚´≈ (SFMx) ´—≈ø“‰¥Õ–´’π
(SFD) ·≈– ´—≈ø“‡¡∑“´’π (SFM) „π ¿“«–∑’ˇªìπ‡∫ À≈—ß®“°∑”„À⇰‘¥ªØ‘°‘√‘¬“‰¥Õ–‚´‰∑´å‡´—π ‰¥â‡ªìπ
“√ª√–°Õ∫ ’ â¡·¥ß´÷Ëß¡’§à“°“√¥Ÿ¥°≈◊π· ß Ÿß ÿ¥∑’˧«“¡¬“«§≈◊Ëπ„πà«ß 500 π“‚π‡¡µ√ ¢’¥®”°—¥µË” ÿ¥„π
°“√«‘‡§√“–Àå¢Õß SFMx, SFD ·≈– SFM ¡’§à“‡∑à“°—∫ 0.0283 0.0292 ·≈– 0.0298 ¡‘≈≈‘°√—¡µàÕ≈‘µ√ µ“¡
≈”¥—∫ §«“¡‡∑’ˬ߄π°“√«‘‡§√“–ÀåÕ¬Ÿà„πà«ß√âÕ¬≈– 0.41 - 5.17 §«“¡·¡àπ„π°“√«‘‡§√“–Àå· ¥ß„π√Ÿª§à“√âÕ¬≈–
°“√°≈—∫§◊πÕ¬Ÿà„πà«ß 92.2 - 123.4 ‰¥âπ”‡∑§π‘§∑’Ëæ—≤π“¢÷Èπ‰ªª√–¬ÿ°µå„â„π°“√À“ª√‘¡“≥ “√°≈ÿà¡´—≈‚øπ“‰¡¥å
∑’Ë¡’„πµ—«Õ¬à“߬“∑“߇¿ —°√√¡µà“ßÊ ‰¥âº≈‡ªìπ∑’Ëπà“æÕ„®
Abstract
A rapid, selective and simple spectrophotometric method for the determination of some sulfonamide
preparations was developed in present work. The method was based on the diazotization reaction of
sulfamethoxazole (SFMx), sulfadiazine (SFD) and sulfamethazine (SFM) with 8-hydroxyquinoline in alkaline
1
¿“§«‘“‡§¡’ §≥–«‘∑¬“»“ µ√å ¡À“«‘∑¬“≈—¬π‡√»«√ ®—ßÀ«—¥æ‘…≥ÿ‚≈° 65000
* Corresponding Author, E-mail : wipharatc@nu.ac.th