Review

ß“π«‘®—¬
«“√ “√«‘∑¬“»“ µ√å ¡¢. ªï∑’Ë 39 ©∫—∫∑’Ë 1 121
media. The absorbance of the resulting orange red azo products were measured at the maximum wavelength
of 500 nm. The limit of detection for SFMx, SFD and SFM were 0.0283, 0.0292 and 0.0298 mg L -1 ,
respectively. The precision (%RSD) in the range of 0.41 - 5.17 % and accuracy (%recovery) in the range of
92.2 - 123.4 % were obtained. The method was successfully applied for the determination of sulfonamides
in various pharmaceutical preparations with satisfactory results.
§” ”§—≠ : ´—≈‚øπ“‰¡¥å ‰¥Õ–‚´‰∑´å‡´—𠇪§‚µ√‚ø‚µ‡¡µ√’ µ—«Õ¬à“߬“
Keywords : Sulfonamides, Diazotization, Spectrophotometry, Pharmaceutical preparations
∫∑π”
¬“°≈ÿà¡´—≈‚øπ“‰¡¥å (sulfonamides) ‡ªìπ¬“
Õ’°π‘¥Àπ÷Ëß∑’Ëπ‘¬¡„â°—πÕ¬à“ß·æ√àÀ≈“¬‡π◊ËÕß®“°¡’ƒ∑∏‘Ï
°«â“ß·≈–¡’ª√– ‘∑∏‘¿“æ„π°“√µâ“π‡◊ÈÕ·∫§∑’‡√’¬∑’Ë¥’
·≈–¡’√“§“∂Ÿ° ‚¥¬π”¡“„â„π°“√∫”∫—¥√—°…“‚√§∑’ˇ°‘¥
®“°‡◊ÈÕ·∫§∑’‡√’¬ ‡àπ ´—≈ø“‰¥Õ–´’π (SFD) π‘¬¡
„â ”À√—∫°“√µ‘¥‡◊ÈÕ∑’˺‘«Àπ—ß ´—≈ø“‡¡∑Õ°´“‚´π
(SFMx) „â„π°“√√—°…“‚√§µ‘¥‡◊ÈÕ„π∑“߇¥‘πªí “«–
(‚Õ¿“ «—√–§ÿªµå, 2551) ·≈–´—≈ø“‡¡∑“´’π (SFM)
„â√—°…“‚√§µ‘¥‡◊ÈÕ„π√à“ß°“¬ (°¡≈—¬ µ√ß«“π‘π“¡,
2544) ´÷Ëß Ÿµ√‚§√ß √â“ߢÕ߬“∑—Èß “¡π‘¥ · ¥ß„π
√Ÿª∑’Ë 1
H 2 N
SO 2 NH
N O CH 3
H 2 N
SO 2 NH
N
N
Sulfamethoxazole (STMx)
Sulfadiazine (SFD)
H 2 N
SO 2 NH
N
N
CH 3
CH 3
Sulfamethazine (SFM)
√Ÿª∑’Ë 1 Ÿµ√‚§√ß √â“ߢÕß´—≈ø“‡¡∑Õ°´“‚´≈ (SFMx) ´—≈ø“‰¥Õ–´’π (SFD) ·≈– ´—≈ø“‡¡∑“´’π (SFM)
(∑’Ë¡“: °¡≈—¬ µ√ß«“π‘π“¡, 2544)
„πªí®®ÿ∫—πºŸâ∫√‘‚¿§π‘¬¡´◊ÈÕ¬“¡“√—°…“‡Õß
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‡àπ ‡°‘¥À≈Õ¥‡≈◊Õ¥·¥ßÕ—°‡ ∫ (arteritis) „πÕ«—¬«–
µà“ßÊ ‡à𠵓 ‰µ µ—∫Õ—°‡ ∫ ‡ªìπµâπ ‚¥¬ƒ∑∏‘Ï·∑√°·´ß
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