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Appendix 1: Literature review on interurban road injury bur<strong>de</strong>n in LMICsMethodsSeveral approaches can be used to review transport safety research such as safety promotionmo<strong>de</strong>l , Haddon’s matrix, and the three ‘E’ (Enforcement, Engineering, and Education) [57,156-158]. For this systematic review, the public health approach was used. Consi<strong>de</strong>ring, thisinterrelationship of risk factor, crash outcome, trauma care, and their reporting, we reviewedstudies if their objective correspon<strong>de</strong>d with one or more of the following research interests:1. Assessing traffic injury bur<strong>de</strong>n (outcome) with respect to age, sex, and road user type.2. Assessing factors associated with outcome.3. Assessing trauma care of crash and injury event and their outcome.4. Assessing reporting mechanism and bias for assessing traffic bur<strong>de</strong>n outcomes, riskfactors, and trauma care.5. Assessing the impact of traffic safety interventions.The focus was studies with interurban road settings to document research needs. Originalresearch published in peer-reviewed journals in<strong>de</strong>xed on MEDLINE for a period from Jan1995 to Dec 2009 was inclu<strong>de</strong>d; reviews, editorials, commentaries, and letters to the editorwere exclu<strong>de</strong>d. Study title and abstract were searched using the following Medical SubjectHeadings (MeSH): “traffic acci<strong>de</strong>nt” and “<strong>de</strong>veloping countries” or individual names ofLMICs given in “Global Status Report on Road Safety.” Then articles concerning interurbanroads were selected. Articles written in English, French, Portuguese, Spanish, and RomanianLanguage were inclu<strong>de</strong>d if they satisfied the following criteria [159]: objective(s) clearlystated; inclusion criteria given and a<strong>de</strong>quate; ethical standards observed; reliable and validprincipal measures.ResultsA total of 3 663 abstracts were retrieved. After removing double entries and case reports, wewere left with 1 960 study abstracts (Figure 15). After careful search of studies conducted athighway or interurban road settings, 37 abstracts correspon<strong>de</strong>d to our criteria. Full texts of 32studies were available; however, we did not inclu<strong>de</strong> a study reporting the results of trafficmanagement intervention using simulation methods.Road crash and injury bur<strong>de</strong>nA Kenyan study showed that almost 60% of police-reported injury crashes occurred oninterurban roads [39]. Injuries including fatalities per crash were higher for interurban roads(1.8) than urban roads (1.4). Interurban traffic crash, fatality, and injury per vehicle-km werereported in one Egyptian study only. Average traffic fatality per km was 6 per 100 millionvehicles-km (range 3 to 11) in the prece<strong>de</strong>nt three-year period [18]. Injury risk was 35 per 100million vehicle-km (range 29 to 79). Fatality per crash ratio was on average 0.30 (range 0.17-0.43) on Egyptian interurban roads [18]. A Chinese study, where fatalities and daily trafficmeasures were available, showed that fatality could vary from 31.1 to 72.8 per 100 millionvehicle-km travelled on mountainous, un-separated interurban roads [48].Road users involved in these crashes were mostly aged 15-45 years-old and men [22, 31].Although some studies showed that pe<strong>de</strong>strians [37] and passengers of public transportvehicles [19] were over-involved in highway crashes, road user distribution was almost neverreported.74

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