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6 Antiinflammatory7 Antibiotics8 Antiviral9 Insecticidal10 Antagonist 29811 Analgesic12 AntifungalDue to various biodynamic activities189-248 of pyrimidines and with a view tohave potent therapeutic agents, the synthesis of 4-(2-(4-chlorophenyl)-8-methyl-1Himidazo[1,2-a]pyridine-3-yl)-6-arylpyrimidine-2-amine have been undertaken by thecondensation of different substituted Chalcones with Guanidine hydrochloride inbasic Medium.The constitution of the products have been delineated by elemental analyses,IR,1 H NMR and further supported by Mass spectroscopy. The products wereassayed for their in vitro biological assay like antibacterial activity towardsLooking to the interesting biological properties of Aminopyrimidine it isworthwhile to prepare Aminopyrimidine bearing different heterocyclic systems ofmedicinal value in order to achieve better therapeutic agents. It has been describedin the following section-III.Section-III : Synthesis and therapeutic evaluation of 4-(2-(4-chlorophenyl)-8-methyl-1H-imidazo[1,2-a]pyridine-3-yl)-6-aryl pyrimidine-2-amine.91Aminopyrimidine…..