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Doshi Rajeev et al. 465 have synthesised and screened antitubercular activity.Some, isoxazoles are found to possess herbicidal 466 , potential antiinflammatory 467and antimicrobial agents. 468Cyclocondensation of (2E)-1-(3,5-Dibromo-4-methoxyphenyl)-3-aryl-prop-2-en-1-ones on reaction with hydroxylamine hydrochloride in presence of acetic acidand sodium acetate to give 3-(3,5-dibromo-4-methoxyphenyl)-5-aryl-isoxazoles. Thecompounds were tested against different microbes for their antimicrobial activity andantitubercular activity. 4695-(Substituted phenyl)-{3-[4-2-methyl-4-(4-hydroxybenzylidene)-5-oxoimidazo-1-yl)]phenyl}-Isoxazole have been prepared by the refluxation for 10 hrs. of4-(4-hydroxybenzylidene)-1-{4-[3-(substituted phenyl)prop-2-enoyl]phenyl}-2-methylimidazol-5-one with hydroxylamine hydrochloride and 40% potassium hydroxidesolution in dioxane. The intermediate 4-(4-hydroxybenzylidene)-1-{4-[3(substitutedphenyl)prop-2-enoyl]phenyl}-2-methyl-imidazol-5-one was synthesized by thecondensation of 1-(4-acetylphenyl)-4-(4-hydroxy benzyl idene)-2-methyl-3,5-dihydroimidazol-5-one with various aldehydes.The antimicrobial activities of theseisoxazoles were also studied. 470Thus, significant biological properties associated with isoxazoles havearoused considerable interest to design the compounds in which benzimidazolemoiety is incorporated. Such compounds have been synthesized and described asunder.Synthesis and therapeutic evaluation of 2-(4-chlorophenyl)-3-(3-aryl-isoxazole-5-yl)-8-methyl-1H-Imidazo[1,2-a]pyridine.136Isoxazole…..