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conversion to the triphosphate derivative and subsequent inhibition of HIVreverse transcriptase. Some of these compounds are simply analogs of thenatural 2’-deoxy- nucleoside in which the 3’-OH group has been replaced witha hydrogen, such as 2’,3’-dideoxycytidine(33), 2’,3’-dideoxyadenosine(34)and 2’,3’-dideoxy thymidine(35). Other analogs contain a 2’-3’ double bond,such as 2’3’- dide-hydro-2’,3’-dideoxythymidine (36). Several related analogswith other modifications to the ribose ring or the heterocyclic base moiety havealso been reported to have activity against HIV or HIV reversetranscriptase. 291,292HOOOHNNH 2NHONNH 2NONNHOOOHNONCH 3HOOOHNONCH 3(33) (34) (35) (36)Recently, P. Khalili et al. 293 have carried out biochemical andpharmacokinetic evaluation of a novel nitric oxide donor pyrimidine nucleosidehybrid drug as a potential anticancer / antiviral agent. Rostom et al. 294have synthesized and screened certain 2-(benzoxazol-2-yl-amino)-3H-4-oxopyrimidines for in vitro anti-HIV activity. R. A. Nugent et al. 295 havesynthesized pyrimidine thio ethers (37) and evaluated for inhibitory propertiesagainst wild-type HIV-1 reverse transcriptase. F. Manetti et al. 296 havesynthesized novel pyrimidines (38) with nanomolar activity toward recombinantHIV-1 and mutant HIV-1 strains.60Pyrimidine…..