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RORH 3 COOH 2 O 2OHH 3 COO(Viii)An efficient epoxidation of chalcones with urea-hydrogen peroxide underultrasound irradn. was carried out in 78-93% yields. Compared with theclassical method, the advantages of protocol are to use a safer oxidant, mildconditions, no toxic solvent and shorter reaction time. 482PHARMACEUTICAL IMPORTANCE :The growing importance of epoxides in the field of natural product chemistryindicates that epoxides from a part of a large number of naturally occurringcompounds. 483 Epoxides have been known to form a part of terpens like linaloolepoxide 484 (II) and also antitumor 485 agent and antibiotics 486 such as Stranmonin B( III ) and Fumaglillin ( IV ).CCH 3C H 3CH3OCH 3CH 3OH 3COH 3 CH 3OOOOOH( II ) ( III )( IV )149Oxirane…..