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INTRODUCTIONThiopyrimidine derivatives first primary synthesise from aliphatic fragmentswas carried out by Frankland and Kolbs in 1848. Since then a many distinct primarysynthetic method have been derived. 307-316 It is also possible to prepare from otherheterocyclic compounds. 317-320M = Sub. PhR 1 = H, NO 2R 2 = H, alkylR 3 = H, alkylR 4 = amino cycloalkylR 1MR 4NR 2 N SR 3Selective antagonists for human α/A receptorsSYNTHETIC ASPECT :Different methods are available in literature.1. By the condensation of β–keto esters with N-methyl thiourea. 3212. By the condensation of β-dintriles with thiourea and gaunidines. 322-3243. By the reaction of β- aldehydo nitrile with formamidine and thiourea. 325-3264. By the condensation of β- keto esters with amidino acetamide. 327PHARMACEUTICAL IMPORTANCEThiopyrimidine derivatives have wide variety of uses. In particular asbiologically active compounds in medicine, so thiopyrimidine derivatives play a vitalrole in many biological processes and as synthetic drugs.1. Antifungal 3282. Anticancer 329,330,33175Thiopyrimidine…..