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called ABPP or bropirimine(2-amino-5-bromo-6-phenyl-4-(3H)-pyrimidinone)(figure 1 and Table 1). 257,258 Bropirimine and related 6-aryl analogs wereexamined extensively for efficacy in virus and tumor models, along with theirimmunomodulatory properties and overall pharmacological effects. 259OH,NH 2,NR 2,N 3Cl,H,NHCH 2,CH 2OH,OCH 2CH 2NH 2F,Cl,Br,I,Et,MeCH=CH 2,Prn,CHCCH 2,CO 2Et,MeCH 2OCH 2CH 2,NO 2,H,Ph,Me, Et, Pr3 N45CH 2Ph,CH 2SiMe 3NH 2,RCONH 2,Me 2N,O 2NNH, Me 2NCH=N,CHONH,OH,H 2NC(=NH)NH2N 61N-OHAlkyl, Aryl,HeteroarylW here, Preliminary SAR of antiviral activity ofpyrim idinones (underlined substituents were active)Table - IAntiviral ActivityMonosubstituted Disubstituted HeterocyclicActive 2-F,OMe, Me 3,5-OMe 1Naphthyl3-F,OMe, Cl, NO2 2,5-Cl2 2-PyrazylMe, CF3, MeCH2CH2O, 3,5-OMe 2,3-pyridylBr,I 3,4-Cl2 2-Furyl4-F, Cl3,5-Cl2Inactive 4-Me, CN, Butyl, 2,3-OMe 2-NapthylOH,OCH2Ph, OMe1-Furyl4-Pyridyl2Quinoline51Pyrimidine…..