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The addition reaction between ethylacetoacetate and α,β-unsaturated ketonegive cyclohexenone via. Michael addition. This reaction has been carried out inbasic media by using sodium ethoxide or anhy. K 2 CO 3 in acetone. During thereaction nucleophillic addition of carbanion take place to the C=C of the acceptor.The α,β-unsaturated compound is known as acceptor and ethylacetoacetate isknown as donor.THERAPEUTIC EVALUATIONCyclohexenones and its derivatives are widely used in pharmaceuticalindustry. Considerable interest has been shown in the chemistry of cyclohexenonesdue to their wide spectrum of therapeutic activities which can be listed as under.1. Herbicidal 3642. Analgesic 3653. Antiinflammatory 3664. Anticonvulsant 3675. Antibacterial 3686. Antithrombitics 3697. Antagonist 3708. Antibiotic 371,3729. Cardiovascular 373Cyclohexenone derivatives which possess plant growth regulatory activityhave been reported. 374,375 Nagao et al. 376 have reported antiarrhythmic cyclohexenones.Collins and co-workers 377 have documented cyclohexenone derivativeswhich possess estrogenic activity. Tvanov et al. 378 have reported antimicrobialactivity of some cyclohexenone derivatives. V. K. Ahluwalia and co-workers 379 haveassessed cyclohexenone derivatives for anti HIV-I, gastric secretion inhibitors andpesticidal activity. Cyclohexenone derivatives have been reported to be active asallergy inhibitors, platelet aggregation inhibitors and fibrinogen antagonist. 380104Cyclohexenone…..