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INTRODUCTIONOxopyrimidines represent one of the most active class of compoundspossessing a wide spectrum of biological activities, such as significant in vitroactivity against unrelated DNA and RNA viruses including polio and Herpes viruses,diuretic, Antitubercular spermicidal, etc.R 1RHNONWhere,R =Substituted PhenylR 1= Substituted ArylSYNTHETIC ASPECT :Different methods are available in literature.1. By the condensation of β–keto esters with N- Substituted urea.2. By the condensation of β-dintriles with urea.3. By the reaction of β- aldehydo nitrile with formamidine and urea.4. By substituted benzaldehyde and substituted acetophenone weresubjected to the Claisen-Schmidt condensation in the presence of alkalialcoholate and and yielded 1-(1-naphthyl)-3-aryl-prop-2-en-1-ones.Compounds reacted with an alcohol solution of Urea in aqueous sodiumhydroxide to yield the corresponding 2-Oxopyrimidines. 298ArCHO+ArCOCH3NaOHMethanolR R 1OUreaAlcoholRNNHR 1O63Oxopyrimidine…..