Download (3100Kb) - Etheses - Saurashtra University

[F] Antimicrobial activity of 6-(2-(4-chlorophenyl)-8-methyl-1H-imidazo[1,2-a]pyridine-3-yl)- 4-aryl pyrimidine-2(H)-one.Antimicrobial testing was carried out as described in part- I ExperimentalSection [E] Page No. 38. The zone of inhibition of the test solution are recorded inTable No.- 2(IA).TABLE NO.- 2(IA) BIOLOGICAL SCREENING OF 6-(2-(4-CHLOROPHENYL-8-METHYL-1H-IMIDAZO[1,2-a]PYRIDINE-3-YL)-4-ARYL PYRIMIDINE-2(H)-ONE.Zone of inhibition in m.mSr.RAntibacterialAntifungalNo.B.coccus S.aureus Pseudo E.coli A.nigermona2(Ia) C 6 H 5 - 16 15 14 13 172(Ib) 4-CH 3 -C 6 H 4 - 14 13 13 14 152(Ic) 4-OCH 3 -C 6 H 4 - 16 14 15 16 132(Id) 4-Cl-C 6 H 4 - 19 18 16 17 142(Ie) 4-F-C 6 H 4 - 15 14 13 16 132(If) 4-Br-C 6 H 4 - 14 13 15 13 142(Ig) 4-NH 2 -C 6 H 4 - 16 15 14 14 152(Ih) 4-NO 2 -C 6 H 4 - 14 13 12 15 162(Ii) 4-OH-C 6 H 4 - 18 17 17 19 18Std n Ampicillin 21 20 23 22 -” Amoxicillin 23 21 20 22 -” Ciprofloxacin 24 23 22 21 -” Norfloxacin 22 22 24 23 -” Greseofulvin - - - - 2373Oxopyrimidine…..