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Doshi Rajeev et al. 465 have synthesised and screened antitubercular activity.Some, isoxazoles are found to possess herbicidal 466 , potential antiinflammatory 467and antimicrobial agents. 468Cyclocondensation of (2E)-1-(3,5-Dibromo-4-methoxyphenyl)-3-aryl-prop-2-en-1-ones on reaction with hydroxylamine hydrochloride in presence of acetic acidand sodium acetate to give 3-(3,5-dibromo-4-methoxyphenyl)-5-aryl-isoxazoles. Thecompounds were tested against different microbes for their antimicrobial activity andantitubercular activity. 4695-(Substituted phenyl)-{3-[4-2-methyl-4-(4-hydroxybenzylidene)-5-oxoimidazo-1-yl)]phenyl}-Isoxazole have been prepared by the refluxation for 10 hrs. of4-(4-hydroxybenzylidene)-1-{4-[3-(substituted phenyl)prop-2-enoyl]phenyl}-2-methylimidazol-5-one with hydroxylamine hydrochloride and 40% potassium hydroxidesolution in dioxane. The intermediate 4-(4-hydroxybenzylidene)-1-{4-[3(substitutedphenyl)prop-2-enoyl]phenyl}-2-methyl-imidazol-5-one was synthesized by thecondensation of 1-(4-acetylphenyl)-4-(4-hydroxy benzyl idene)-2-methyl-3,5-dihydroimidazol-5-one with various aldehydes.The antimicrobial activities of theseisoxazoles were also studied. 470Thus, significant biological properties associated with isoxazoles havearoused considerable interest to design the compounds in which benzimidazolemoiety is incorporated. Such compounds have been synthesized and described asunder.Synthesis and therapeutic evaluation of 2-(4-chlorophenyl)-3-(3-aryl-isoxazole-5-yl)-8-methyl-1H-Imidazo[1,2-a]pyridine.136Isoxazole…..
SYNTHESISAND THERAPEUTIC EVALUATION OF 2-(4-CHLOROPHENYL)-3-(3-ARYL-ISOXAZOLE-5-YL)-8-METHYL-1H-IMIDAZO[1,2-a]PYRIDINE.Isoxazole derivatives have created interest in the field of medicinal chemistry,due to wide rage of biological activities exhibited by them. Prompted by these facts,the preparation of Isoxazole of type (III) was carried out by condensing chalconeswith hydroxylamine hydrochloride in the presence of sodium acetate.CH 3NNClONRWhere,R= ArylType (III)The constitution of the synthesized products has been characterized by usingelemental analyses, infra red and 1 H nuclear magnetic resonance spectroscopy andfurther supported by mass spectroscopy.The products have been screened for their in vitro biological assay likeantibacterial activity towards Gram positive and Gram negative bacterial strainsand antifungal activity towards Aspergillus niger at a concentration of 40μg. Thebiological activities of the synthesized compounds have been compared withstandard drugs.137Isoxazole…..
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The Sarvodaya Education Society’s
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selfless help, moral support and gu
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Introduction and Spectral studies .
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“STUDIES ON SOME HETEROCYCLICENTI
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Pyrimidine derivatives have been pr
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Isoxazole derivative synthesized by
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“STUDIES ON SOMEHETEROCYCLIC ENTI
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(b) Pharmacokinetics: It is derived
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(C) Drug DevelopmentMany natural pr
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The process of drug design is exten
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(l) Non steroidal anti-inflammatory
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INTRODUCTIONThe aza-indolizine cont
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PHARMACEUTICAL IMPORTANTMuch resear
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Compd. R 1 R 2 R 3a :- H 7-Me-6,8-B
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S. Kristjan, Gudmundsson and A. Bra
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STUDIES ON IMIDAZOPYRIDINE DERIVATI
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(a) Chalcones with monoethanolamine
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Das B.P. et al. 111 have found that
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Furthermore, Alcaraz M.J, et al. 13
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REACTION SCHEMECl+ClOClOClClCH 3NH
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Instrument : SHIMADZU FTIR 8400 Spe
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SignalNo.SignalPosition(δppm)Relat
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ANTIMICROBIAL ACTIVITYProducts : Ch
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The reaction mixture was poured on
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TABLE NO.- 1A BIOLOGICAL SCREENING
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PART-IISTUDIES ON PYRIMIDINES
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The self consistent (pi)electron de
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class of dye viz. trichloro pyrimid
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ability to cleave nucleic acid targ
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SSNHNHoONOoONOo(11) (12)oOHThe Pyri
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called ABPP or bropirimine(2-amino-
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acid so that it could be utilized f
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have reported the 5-substitutedfuro
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maturation of the viral mRNA molecu
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Nevertheless, these compounds const
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OHHNCH 3Cl(CH 2 )nSNNR 2R 1N H 2NSR
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SECTION-ISTUDIES ONOXOPYRIMIDINES
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PHARMACEUTICAL IMPORTANCEIn recent
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REACTION SCHEMECH 3NNCHOCl10% KOH R
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INSTRUMENT :SHIMADZU FTIR 8400 Spec
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SignalNo.SignalPosition(δppm)Relat
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EXPERIMENTALSynthesis and therapeut
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TABLE NO.- 2(IB)PHYSICAL CONSTANTS
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INTRODUCTIONThiopyrimidine derivati
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H 3 COHNRH 3 CH 3 CNHS( IV ) R = ar
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SYNTHESIS AND THERAPEUTIC EVALUATIO
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IR SPECTRAL STUDIES OF 6-(2-(4-CHLO
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NMR SPECTRAL STUDIES OF 6-(2-(4-CHL
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MASS SPECTRAL STUDIES OF 6-(2-(4-CH
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[F] Antimicrobial activity of 6-(2-
Page 105 and 106: SECTION-IIISTUDIES ONAMINOPYRIMIDIN
Page 107 and 108: ArCHO+ArCOCH3NaOHMethanolR R 1ONaOH
Page 109 and 110: SYNTHESIS AND THERAPEUTIC EVALUATIO
Page 111 and 112: IR SPECTRAL STUDIES OF 4-(2-(4-CHLO
Page 113 and 114: NMR SPECTRAL STUDIES OF 4-(2-(4-CHL
Page 115 and 116: MASS SPECTRAL STUDIES OF 4-(2-(4-CH
Page 117 and 118: [F] Antimicrobial activity of 4-(2-
Page 119 and 120: PART-IIISTUDIES ONCYCLOHEXENONES
Page 121 and 122: 2. Michael addition of chalcone wit
Page 123 and 124: Rheinheimer J. et al. 381have synth
Page 127 and 128: IR SPECTRAL STUDIES OF ETHYL-6-(2-(
Page 129 and 130: NMR SPECTRAL STUDIES OF ETHYL-6-(2-
Page 131 and 132: MASS SPECTRAL STUDIES OF ETHYL-6-(2
Page 133 and 134: Antimicrobial testing was carried o
Page 135 and 136: PART-IVSTUDIES ON PYRAZOLINES
Page 137 and 138: H 2 C= CHCN + Ar - NHNH 2NArN(3) 2
Page 139 and 140: PHARMACEUTICAL IMPORTANCE :2- Pyraz
Page 141 and 142: Kadu et al. 424 and antimicrobial b
Page 143 and 144: REACTION SCHEMECH 3NNClCHO10% KOHRO
Page 145 and 146: Instrument : SHIMADZU FTIR 8400 Spe
Page 147 and 148: SignalNo.SignalPosition(δppm)Relat
Page 149 and 150: EXPERIMENTALSynthesis and therapeut
Page 151 and 152: TABLE NO.- 4(B)PHYSICAL CONSTANTS O
Page 153 and 154: INTRODUCTION:Isoxazole come under t
Page 155: PHARMACEUTICAL IMPORTANCE :Isoxazol
Page 159 and 160: IR SPECTRAL STUDIES OF 2-(4-CHLOROP
Page 161 and 162: NMR SPECTRAL STUDIES OF 2-(4-CHLORO
Page 163 and 164: MASS SPECTRAL STUDIES OF 2-(4-CHLOR
Page 165 and 166: [F]Antimicrobial activity of 2-(4-c
Page 167 and 168: PART-VISTUDIES ON OXIRANES
Page 169 and 170: ( iii ) Epoxidation can also been c
Page 171 and 172: Moreover, Nomura Yutaka et al. 487
Page 175 and 176: IR SPECTRAL STUDIES OF (3-(2-(4-CHL
Page 177 and 178: NMR SPECTRAL STUDIES OF (3-(2-(4-CH
Page 179 and 180: MASS SPECTRAL STUDIES OF (3-(2-(4-C
Page 181 and 182: [F] Antimicrobial activity of (3-(2
Page 184 and 185: 1. J. A. Joule and K. Mills; Hetero
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Page 188 and 189: 78. Ms. B. S. Hastak and B. J. Ghiy
Page 190 and 191: 116. V. R. Mudalir and V. Joshi ; I
Page 192 and 193: 150. S. Inoue, A. J. Saggimoto and
Page 194 and 195: 197. S. S. Bahekar, D. B. Shinde; A
Page 196 and 197: 238. A. Kreutzberger and M. Sellhei
Page 198 and 199: 280. See, for example, W. H. Prusof
Page 200 and 201: 326. C. W. Whitehead and J. J. Trav
Page 202 and 203: 366. Nagarjan K., Shenoy S. J.; Ind
Page 204 and 205: 396. Ausra Voskiene,Vytautas Mickev
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432. Solankee Sejal; Prajapati Yoge
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463. Mishra Ashutosh ; Jain Sanmati
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496. Kaneko Mashami, Saitoh Yutaka,
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CH 3CH 3NNClNNClORHNONRRRC 6 H 5 -
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CH 3CH 3NNClNNClEtOOCORHNNRRRC 6 H
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