Download (3100Kb) - Etheses - Saurashtra University

PHARMACEUTICAL IMPORTANCEIn recent years, dihydropyrimidinones and their derivatives have receivedconsiderable attention in natural and synthetic organic chemistry because of theirtherapeutic and pharmacological properties. 299-306Oxopyrimidine derivatives have wide variety of uses. In particular asbiologically active compounds in medicine1. Antihypertensive 299-3022. α-1a-antagonists 299-3023. Neuropeptide Y antagonists. 299-3024. HIV gp-120-CDA inhibitors 299-3025. Antibacterial 303-306Due to various biodynamic activities of pyrimidines and with a view tohave potent therapeutic agents, the synthesis of 6-(2-(4-chlorophenyl)-8-methyl-1Himidazo[1,2-a]pyridine-3-yl)-4-arylpyrimidine-2(H)-one have been undertaken by thecondensation of different substituted chalcones with urea in basic medium.The constitution of the products have been delineated by elemental analyses,IR, 1 H NMR and Mass spectral data. The products were assayed for their in vitrobiological assay like antibacterial activity toward A. niger.Looking to the interesting biological properties of oxopyrimidine it isworthwhile to prepare some new derivative of oxopyrimidine bearing differentheterocyclic systems of medicinal value in order to achieve better therapeuticagents. It has been described in the following section-I.Section-I :Synthesis and therapeutic evaluation of 6-(2-(4-chlorophenyl)-8-methyl-1H-imidazo[1,2-a]pyridine-3-yl)-4-aryl pyrimidine-2(H)-one.64Oxopyrimidine…..