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ROSONOCF 3OONHRR 1OOR 2O( VII) ( VIII) ( IX )OOJanada Kim D. 495 synthesised a series of novel oxirane derivatives. Whichare useful for inhibiting HIV-1 protease. Kaneko Masami et al. 496 synthesized epoxycyclohexene dione (VIII) and reported as antibacterial and antitumor agent. SalqdinoRaffaele et al. 497 prepared new 6-oxiranyl uracils which showed a potent andselective antiviral activity against the Para influenza 1-virus replication. TamogamiShigeru et al. 498 prepared epoxy cyclopentyl benzyl ether derivatives which possess100% herbicidal activity against Echinochloa Crus-galli at 1ppm concentration.Some epoxy keto furanosides (IX) have been reported as antitumor agents byKobayashi Shin et al. 499 Further more, several derivatives of oxirane have beenpatented for their use as antitumor 500 , antibacterial agents 501 , herbicides 502 , HIVprotease503 inhibitors etc. Target compounds and intermediates were assayed foranti-inflammatory effects on superoxide anion generation and elastase release byhuman neutrophils in response to fMLP /CB, and for cytotoxic activity againstnasopharyngeal (KB), vincristine-resistant nasopharyngeal (KBvin), lung (A549) andprostate (DU-145) human cancer cell lines. 504Led by this consideration several chalcone epoxides have been synthesisedand evaluated for their biological screening described as under.Synthesis and therapeutic evaluation of (3-(2-(4-chlorophenyl)-8-methyl-1Himidazo[1,2-a]pyridine-3-yl)oxirane-2-yl)aryl methanone.151Oxirane…..