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SYNTHESIS AND THERAPEUTIC EVALUATION OF (3-(2-(4-CHLOROPHENYL)-8-METHYL-1H-IMIDAZO[1,2-a]PYRIDINE-3-YL)OXIRANE-2-YL) ARYL METHAN-ONE.The chemistry of oxiranes has assumed importance because of theirversatility in the synthesis of many heterocycles and polymeric compounds. Furthermore, epoxides are also associated with spectrum of biological activities. Keepingthis in view, we have prepared some oxiranes compounds by the oxidation ofChalcone using alkaline H 2 O 2 shown as under.CH 3CH 3NWhere,R = ArylNORClAq. NaOH30% H 2O 2Methanol +AcetoneNWhere,R= ArylNOORClThe structure elucidation of the synthesized compounds have been done onthe basis of elemental analyses, Infrared and 1 H-nuclear magnetic resonancespectroscopy and further supported by Mass spectroscopy.The products have been evaluated for their in vitro antibacterial activitytowards Gram positive and Gram negative bacterial stains and antifungal activitytowards Aspergillus niger at a concentration of 40μg/ml. The biological activities ofsynthesized compounds were compared with standard drugs.152Oxirane…..