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INTRODUCTION:Isoxazole come under the class of compounds containing two heteroatom infive membered ring, Oxygen and Nitrogen.NO( I )This type of structure (I) was first reported by Claisen for the product obtainedby the reaction of 1,3-Diketone with hydroxylamine. 426 More work for Isoxazole wasdone by Claisen and his students 427,428 to provide solid foundation of Isoxazolechemistry. Not only that, other scientist Cremlico gave important contribution tounderstand Isoxazole chemistry. Isoxazoles shows typical properties of an aromaticsystem, but under the conditions, particularly reducing or basic media, it becomeshighly labile.SYNTHETIC ASPECT :Isoxazoles may be prepared by reaction between hydroxylamine and α, β-dicarbonyl compound. The reaction proceeds via the formation of an oxime, whichpossibly undergoes cyclisation.O ONH 2 OHR-C-CH 2 -C-RROHRNOHRNOROH-H 2 ORNOR133Isoxazole…..