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R'OHNNORNR 1NCH 3CH 3H 3 COCOOR(V)R,R'= AlkylO(VI)R,R'= AlkylOH 3 CCH 3(VII)Moreover, H. H. Parekh and co-workers 392 have synthesised 6-carbethoxy-5-(4'-cinnamoyloxyphenyl)-3-aryl-2-cyclohexenones and all the products havebeen evaluated for their antimicrobial activity. Zhang C. et al. 393 have preparedtricyclic heterocycles, containing furan and cyclohexenone nucleus for treatinghyperproliferative disorders. Under the high-speed vibration milling conditions,K 2 CO 3 was found to be a very efficient catalyst for the solvent-free Michael reactionsof 1,3-dicarbonyl compounds with chalcones,e.g., I (X=CH) and aza chalcones,e.g.,I (X=N). In most cases, conventional side reactions were avoided and excellentyields were achieved. The influences of other catalysts and the vibration frequencyon the Michael reaction were also investigated. 394With a view to getting better therapeutic agent, it was contemplated tosynthesised cyclohexenones bearing furan nucleus to enhance the overall activity ofresulting compounds, which have been described as under.Synthesis and therapeutic evaluation of ethyl-6-(2-(4-chlorophenyl)-8-methyl-1H-imidazo[1,2-a]pyridine-3-yl)-4-aryl-2-oxocyclohex-3-ene-carboxylate.106Cyclohexenone…..